Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats
In this study, we investigated the effects of intrahippocampal infusion of indomethacin as a non-selective cyclooxygenase inhibitor and celecoxib as a selective cyclooxygenase-2 inhibitor on spatial memory in the Morris water maze. Rats were trained for 3 days; each day included two blocks, and each...
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| Veröffentlicht in: | European journal of pharmacology 2005-03, Vol.511 (2), p.159-166 |
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| container_title | European journal of pharmacology |
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| creator | Sharifzadeh, Mohammad Naghdi, Nasser Khosrovani, Sara Ostad, Seyed Nasser Sharifzadeh, Kurdistan Roghani, Ali |
| description | In this study, we investigated the effects of intrahippocampal infusion of indomethacin as a non-selective cyclooxygenase inhibitor and celecoxib as a selective cyclooxygenase-2 inhibitor on spatial memory in the Morris water maze. Rats were trained for 3 days; each day included two blocks, and each block contained 4 trials. Tests were performed 48 h after surgery. Bilateral intrahippocampal infusion of indomethacin (0.01, 0.1, or 1 M) did not show any significant effect on spatial memory retention at these concentrations in rats. We also examined effects of infusion of celecoxib (0.02, 0.06, or 0.1 M) on memory retention. Bilateral infusion of 0.1 M celecoxib significantly altered escape latency and traveled distance in rats. These results strongly suggest that cyclooxygenase-2 is involved in spatial memory retention. |
| doi_str_mv | 10.1016/j.ejphar.2005.01.041 |
| format | Article |
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Rats were trained for 3 days; each day included two blocks, and each block contained 4 trials. Tests were performed 48 h after surgery. Bilateral intrahippocampal infusion of indomethacin (0.01, 0.1, or 1 M) did not show any significant effect on spatial memory retention at these concentrations in rats. We also examined effects of infusion of celecoxib (0.02, 0.06, or 0.1 M) on memory retention. Bilateral infusion of 0.1 M celecoxib significantly altered escape latency and traveled distance in rats. These results strongly suggest that cyclooxygenase-2 is involved in spatial memory retention.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2005.01.041</identifier><identifier>PMID: 15792784</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Celecoxib ; Cyclooxygenase ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors - pharmacology ; Dimethyl Sulfoxide - pharmacology ; Dose-Response Relationship, Drug ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; Indomethacin - pharmacology ; Male ; Maze Learning - drug effects ; Medical sciences ; Memory - drug effects ; Morris water maze ; Pharmacology. Drug treatments ; Prostaglandin-Endoperoxide Synthases - metabolism ; Pyrazoles - pharmacology ; Rats ; Rats, Wistar ; Retention (Psychology) - drug effects ; Stereotaxic surgery ; Sulfonamides - pharmacology ; Swimming ; Time Factors</subject><ispartof>European journal of pharmacology, 2005-03, Vol.511 (2), p.159-166</ispartof><rights>2005 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-258724f2cd069d953eed7d65601a1bbccfa4219436a25411ed501fe4853a8b443</citedby><cites>FETCH-LOGICAL-c487t-258724f2cd069d953eed7d65601a1bbccfa4219436a25411ed501fe4853a8b443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2005.01.041$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16633507$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15792784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharifzadeh, Mohammad</creatorcontrib><creatorcontrib>Naghdi, Nasser</creatorcontrib><creatorcontrib>Khosrovani, Sara</creatorcontrib><creatorcontrib>Ostad, Seyed Nasser</creatorcontrib><creatorcontrib>Sharifzadeh, Kurdistan</creatorcontrib><creatorcontrib>Roghani, Ali</creatorcontrib><title>Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>In this study, we investigated the effects of intrahippocampal infusion of indomethacin as a non-selective cyclooxygenase inhibitor and celecoxib as a selective cyclooxygenase-2 inhibitor on spatial memory in the Morris water maze. Rats were trained for 3 days; each day included two blocks, and each block contained 4 trials. Tests were performed 48 h after surgery. Bilateral intrahippocampal infusion of indomethacin (0.01, 0.1, or 1 M) did not show any significant effect on spatial memory retention at these concentrations in rats. We also examined effects of infusion of celecoxib (0.02, 0.06, or 0.1 M) on memory retention. Bilateral infusion of 0.1 M celecoxib significantly altered escape latency and traveled distance in rats. These results strongly suggest that cyclooxygenase-2 is involved in spatial memory retention.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Celecoxib</subject><subject>Cyclooxygenase</subject><subject>Cyclooxygenase 2</subject><subject>Cyclooxygenase 2 Inhibitors</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Dimethyl Sulfoxide - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Indomethacin - pharmacology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Morris water maze</subject><subject>Pharmacology. Drug treatments</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>Pyrazoles - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Retention (Psychology) - drug effects</subject><subject>Stereotaxic surgery</subject><subject>Sulfonamides - pharmacology</subject><subject>Swimming</subject><subject>Time Factors</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFr3DAQhUVpSbZp_kEpujQ3uxpZsuxLoSxNUwikhxZ6E7I07mqxLVfSlubfV8su5NacZhi-93jMI-QtsBoYtB_2Ne7XnYk1Z0zWDGom4AXZQKf6iingL8mGMRAV7_v-krxOac8K2HN5QS5Bqp6rTmxI_BZSrnI0fvHLL-qXsu78ugZr5tVM5TAekg8LDSPNO6Tbh58VL9edH3wOkVqc0Ia_fqC-8D6io2k12RfpjHOIjzRixiUfLfxCo8npDXk1minh9XlekR-3n79v76r7hy9ft5_uKys6lSsuO8XFyK1jbe962SA65VrZMjAwDNaORnDoRdMaLgUAOslgRNHJxnSDEM0VuTn5rjH8PmDKevap5J3MguGQdKtky6FtngVByaZh3dFRnEAbQ0oRR71GP5v4qIHpYyl6r0-l6GMpmoEupRTZu7P_YZjRPYnOLRTg_RkwyZppjGaxPj1xbQkpmSrcxxOH5W1_PEadrMfFoiuPt1m74P-f5B9OSq1_</recordid><startdate>20050328</startdate><enddate>20050328</enddate><creator>Sharifzadeh, Mohammad</creator><creator>Naghdi, Nasser</creator><creator>Khosrovani, Sara</creator><creator>Ostad, Seyed Nasser</creator><creator>Sharifzadeh, Kurdistan</creator><creator>Roghani, Ali</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20050328</creationdate><title>Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats</title><author>Sharifzadeh, Mohammad ; Naghdi, Nasser ; Khosrovani, Sara ; Ostad, Seyed Nasser ; Sharifzadeh, Kurdistan ; Roghani, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-258724f2cd069d953eed7d65601a1bbccfa4219436a25411ed501fe4853a8b443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Celecoxib</topic><topic>Cyclooxygenase</topic><topic>Cyclooxygenase 2</topic><topic>Cyclooxygenase 2 Inhibitors</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Dimethyl Sulfoxide - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Indomethacin - pharmacology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Morris water maze</topic><topic>Pharmacology. Drug treatments</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>Pyrazoles - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Retention (Psychology) - drug effects</topic><topic>Stereotaxic surgery</topic><topic>Sulfonamides - pharmacology</topic><topic>Swimming</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharifzadeh, Mohammad</creatorcontrib><creatorcontrib>Naghdi, Nasser</creatorcontrib><creatorcontrib>Khosrovani, Sara</creatorcontrib><creatorcontrib>Ostad, Seyed Nasser</creatorcontrib><creatorcontrib>Sharifzadeh, Kurdistan</creatorcontrib><creatorcontrib>Roghani, Ali</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharifzadeh, Mohammad</au><au>Naghdi, Nasser</au><au>Khosrovani, Sara</au><au>Ostad, Seyed Nasser</au><au>Sharifzadeh, Kurdistan</au><au>Roghani, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2005-03-28</date><risdate>2005</risdate><volume>511</volume><issue>2</issue><spage>159</spage><epage>166</epage><pages>159-166</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>In this study, we investigated the effects of intrahippocampal infusion of indomethacin as a non-selective cyclooxygenase inhibitor and celecoxib as a selective cyclooxygenase-2 inhibitor on spatial memory in the Morris water maze. Rats were trained for 3 days; each day included two blocks, and each block contained 4 trials. Tests were performed 48 h after surgery. Bilateral intrahippocampal infusion of indomethacin (0.01, 0.1, or 1 M) did not show any significant effect on spatial memory retention at these concentrations in rats. We also examined effects of infusion of celecoxib (0.02, 0.06, or 0.1 M) on memory retention. Bilateral infusion of 0.1 M celecoxib significantly altered escape latency and traveled distance in rats. These results strongly suggest that cyclooxygenase-2 is involved in spatial memory retention.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15792784</pmid><doi>10.1016/j.ejphar.2005.01.041</doi><tpages>8</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Behavior, Animal - drug effects Biological and medical sciences Celecoxib Cyclooxygenase Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Dimethyl Sulfoxide - pharmacology Dose-Response Relationship, Drug Hippocampus Hippocampus - drug effects Hippocampus - physiology Indomethacin - pharmacology Male Maze Learning - drug effects Medical sciences Memory - drug effects Morris water maze Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - metabolism Pyrazoles - pharmacology Rats Rats, Wistar Retention (Psychology) - drug effects Stereotaxic surgery Sulfonamides - pharmacology Swimming Time Factors |
| title | Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats |
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