Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis

The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphy...

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Veröffentlicht in:	FEBS letters 2005-03, Vol.579 (9), p.1917-1922
Hauptverfasser:	Ekkelenkamp, Miquel B., Hanssen, Micha, Danny Hsu, Shang-Te, de Jong, Ad, Milatovic, Dana, Verhoef, Jan, van Nuland, Nico A.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-methyllanthionine Amino Acid Sequence Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Antibacterial peptides Bacteriocins dehydroalanine dehydrobutyrine Dha Dhb heteronuclear multiple bond correlation heteronuclear single-quantum correlation HMBC Hop HSQC hydroxy-propionyl Lan lanthionine Lantibiotics Magnetic Resonance Spectroscopy Mass spectrometry MeLan Molecular Sequence Data MS/MS NMR NOESY Nuclear magnetic resonance nuclear Overhauser enhancement spectroscopy Peptides - chemistry Peptides - isolation & purification Primary sequence determination Protein Processing, Post-Translational Protein Structure, Tertiary Staphylococcus epidermidis Staphylococcus epidermidis - metabolism tandem mass spectrometry TOCSY total correlation spectroscopy
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