Bacterial Endotoxin (lipopolysaccharide) Stimulates Interleukin-6 Production and Inhibits Growth of Pituitary Tumour Cells Expressing the Toll-Like Receptor 4

Members of the Toll receptor (Tlr) family have a crucial role in the innate immune response following bacterial infection. The effects of Gram‐negative bacteria‐derived endotoxins (lipopolysaccharide, LPS) are predominantly mediated by Tlr4, and we have recently shown that pituitary folliculostellat...

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Veröffentlicht in:	Journal of neuroendocrinology 2005-03, Vol.17 (3), p.152-160
Hauptverfasser:	Tichomirowa, M., Theodoropoulou, M., Lohrer, P., Schaaf, L., Losa, M., Uhl, E., Lange, M., Arzt, E., Stalla, G. K., Renner, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - immunology Adenoma - metabolism Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Cell Proliferation Cells, Cultured Epithelial Cells - immunology Epithelial Cells - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic - immunology Humans Immunohistochemistry interleukin-6 Interleukin-6 - genetics Interleukin-6 - metabolism lipopolysaccharide Lipopolysaccharides - immunology Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Middle Aged Pituitary Neoplasms - genetics Pituitary Neoplasms - immunology Pituitary Neoplasms - metabolism pituitary tumours Prolactinoma - genetics Prolactinoma - immunology Prolactinoma - metabolism proliferation Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Reference Values RNA, Messenger - analysis Tlr4 Toll-Like Receptor 4 Toll-Like Receptors Tumor Cells, Cultured Vertebrates: endocrinology
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