Korea red ginseng water extract increases nitric oxide concentrations in exhaled breath
Panax ginseng is well known to enhance the release of nitric oxide (NO) from endothelial cells of the rat aorta and to reduce blood pressure in animals. In this study, we investigated the effects of water extract of Korea red ginseng (KRG) on NO concentration levels in the exhaled breath, blood pres...
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| Veröffentlicht in: | Nitric oxide 2005-05, Vol.12 (3), p.159-162 |
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| creator | Han, Kun Shin, Im-Chul Choi, Kang-Ju Yun, Yeo-Pyo Hong, Jin-Tae Oh, Ki-Wan |
| description | Panax ginseng is well known to enhance the release of nitric oxide (NO) from endothelial cells of the rat aorta and to reduce blood pressure in animals. In this study, we investigated the effects of water extract of Korea red ginseng (KRG) on NO concentration levels in the exhaled breath, blood pressure, and heart rate of human volunteers. We also are interested in whether NO levels in exhaled breath are increased by KRG extract, and correlated with blood pressure and heart rate. Twelve healthy, non-smoking male volunteers were recruited for this study. A single administration of KRG water extract (500
mg/50
kg) increased NO levels in exhaled breath, and concomitantly decreased mean blood pressure and heart rate. The correlation value between NO levels and heart rate (
r
=
0.94), and the correlation value between NO levels and heart rate (
r
=
0.84) are significant (
P
<
0.01). Linear regression analysis shows the clear conversed correlation between NO levels and blood pressure as well as heart rate. Therefore, present data suggest that KRG may be useful for the treatment of hypertension and pulmonary vascular obstruction. |
| doi_str_mv | 10.1016/j.niox.2005.02.001 |
| format | Article |
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mg/50
kg) increased NO levels in exhaled breath, and concomitantly decreased mean blood pressure and heart rate. The correlation value between NO levels and heart rate (
r
=
0.94), and the correlation value between NO levels and heart rate (
r
=
0.84) are significant (
P
<
0.01). Linear regression analysis shows the clear conversed correlation between NO levels and blood pressure as well as heart rate. Therefore, present data suggest that KRG may be useful for the treatment of hypertension and pulmonary vascular obstruction.</description><identifier>ISSN: 1089-8603</identifier><identifier>EISSN: 1089-8611</identifier><identifier>DOI: 10.1016/j.niox.2005.02.001</identifier><identifier>PMID: 15797844</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antihypertensive Agents - pharmacology ; Blood Pressure - drug effects ; Breath Tests ; Heart Rate - drug effects ; Humans ; Male ; Medicine, East Asian Traditional ; Nitric Oxide - biosynthesis ; Panax - chemistry ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; Solutions - chemistry ; Water - chemistry</subject><ispartof>Nitric oxide, 2005-05, Vol.12 (3), p.159-162</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-3050083ebf435a17463a6a6a0411357c03785b8b2a7716e249ac113f6a3369a13</citedby><cites>FETCH-LOGICAL-c420t-3050083ebf435a17463a6a6a0411357c03785b8b2a7716e249ac113f6a3369a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.niox.2005.02.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15797844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Kun</creatorcontrib><creatorcontrib>Shin, Im-Chul</creatorcontrib><creatorcontrib>Choi, Kang-Ju</creatorcontrib><creatorcontrib>Yun, Yeo-Pyo</creatorcontrib><creatorcontrib>Hong, Jin-Tae</creatorcontrib><creatorcontrib>Oh, Ki-Wan</creatorcontrib><title>Korea red ginseng water extract increases nitric oxide concentrations in exhaled breath</title><title>Nitric oxide</title><addtitle>Nitric Oxide</addtitle><description>Panax ginseng is well known to enhance the release of nitric oxide (NO) from endothelial cells of the rat aorta and to reduce blood pressure in animals. In this study, we investigated the effects of water extract of Korea red ginseng (KRG) on NO concentration levels in the exhaled breath, blood pressure, and heart rate of human volunteers. We also are interested in whether NO levels in exhaled breath are increased by KRG extract, and correlated with blood pressure and heart rate. Twelve healthy, non-smoking male volunteers were recruited for this study. A single administration of KRG water extract (500
mg/50
kg) increased NO levels in exhaled breath, and concomitantly decreased mean blood pressure and heart rate. The correlation value between NO levels and heart rate (
r
=
0.94), and the correlation value between NO levels and heart rate (
r
=
0.84) are significant (
P
<
0.01). Linear regression analysis shows the clear conversed correlation between NO levels and blood pressure as well as heart rate. Therefore, present data suggest that KRG may be useful for the treatment of hypertension and pulmonary vascular obstruction.</description><subject>Antihypertensive Agents - pharmacology</subject><subject>Blood Pressure - drug effects</subject><subject>Breath Tests</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine, East Asian Traditional</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Panax - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Solutions - chemistry</subject><subject>Water - chemistry</subject><issn>1089-8603</issn><issn>1089-8611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAUx4Mobk7_AQ_Sk7fWl6ZNW_Ai4i8ceFE8hjR93TK6ZCaZzv_ejA29yTvkQT7fL7wPIecUMgqUXy0yo-0mywHKDPIMgB6QMYW6SWtO6eHvDmxETrxfAEDBan5MRrSsmqouijF5f7YOZeKwS2baeDSz5EsGdAlugpMqJNqoCHj0idHBaZXYje4wUdYoNBEJ2hofqRiYyyHWtBEP81Ny1MvB49n-nZC3-7vX28d0-vLwdHszTVWRQ0gZlAA1w7YvWClpVXAmeRwoKGVlpYBVddnWbS6rinLMi0aq-NNzyRhvJGUTcrnrXTn7sUYfxFJ7hcMgDdq1F7wqOeVQRjDfgcpZ7x32YuX0UrpvQUFsdYqF2OoUW50CchF1xtDFvn3dLrH7i-z9ReB6B2C88VOjE15pjGo67VAF0Vn9X_8PYfiGIQ</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Han, Kun</creator><creator>Shin, Im-Chul</creator><creator>Choi, Kang-Ju</creator><creator>Yun, Yeo-Pyo</creator><creator>Hong, Jin-Tae</creator><creator>Oh, Ki-Wan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Korea red ginseng water extract increases nitric oxide concentrations in exhaled breath</title><author>Han, Kun ; Shin, Im-Chul ; Choi, Kang-Ju ; Yun, Yeo-Pyo ; Hong, Jin-Tae ; Oh, Ki-Wan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-3050083ebf435a17463a6a6a0411357c03785b8b2a7716e249ac113f6a3369a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antihypertensive Agents - pharmacology</topic><topic>Blood Pressure - drug effects</topic><topic>Breath Tests</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine, East Asian Traditional</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Panax - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal - chemistry</topic><topic>Solutions - chemistry</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Kun</creatorcontrib><creatorcontrib>Shin, Im-Chul</creatorcontrib><creatorcontrib>Choi, Kang-Ju</creatorcontrib><creatorcontrib>Yun, Yeo-Pyo</creatorcontrib><creatorcontrib>Hong, Jin-Tae</creatorcontrib><creatorcontrib>Oh, Ki-Wan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nitric oxide</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Kun</au><au>Shin, Im-Chul</au><au>Choi, Kang-Ju</au><au>Yun, Yeo-Pyo</au><au>Hong, Jin-Tae</au><au>Oh, Ki-Wan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Korea red ginseng water extract increases nitric oxide concentrations in exhaled breath</atitle><jtitle>Nitric oxide</jtitle><addtitle>Nitric Oxide</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>12</volume><issue>3</issue><spage>159</spage><epage>162</epage><pages>159-162</pages><issn>1089-8603</issn><eissn>1089-8611</eissn><abstract>Panax ginseng is well known to enhance the release of nitric oxide (NO) from endothelial cells of the rat aorta and to reduce blood pressure in animals. In this study, we investigated the effects of water extract of Korea red ginseng (KRG) on NO concentration levels in the exhaled breath, blood pressure, and heart rate of human volunteers. We also are interested in whether NO levels in exhaled breath are increased by KRG extract, and correlated with blood pressure and heart rate. Twelve healthy, non-smoking male volunteers were recruited for this study. A single administration of KRG water extract (500
mg/50
kg) increased NO levels in exhaled breath, and concomitantly decreased mean blood pressure and heart rate. The correlation value between NO levels and heart rate (
r
=
0.94), and the correlation value between NO levels and heart rate (
r
=
0.84) are significant (
P
<
0.01). Linear regression analysis shows the clear conversed correlation between NO levels and blood pressure as well as heart rate. Therefore, present data suggest that KRG may be useful for the treatment of hypertension and pulmonary vascular obstruction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15797844</pmid><doi>10.1016/j.niox.2005.02.001</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antihypertensive Agents - pharmacology Blood Pressure - drug effects Breath Tests Heart Rate - drug effects Humans Male Medicine, East Asian Traditional Nitric Oxide - biosynthesis Panax - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Solutions - chemistry Water - chemistry |
| title | Korea red ginseng water extract increases nitric oxide concentrations in exhaled breath |
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