Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct

Certain bispecific antibodies exhibit an extraordinary potency and efficacy for target cell lysis by eliciting a polyclonal T‐cell response. One example is a CD19‐/CD3‐bispecific single‐chain antibody construct (bscCD19xCD3), which at femtomolar concentrations can redirect cytotoxic T cells to elimi...

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Veröffentlicht in:	International journal of cancer 2005-05, Vol.115 (1), p.98-104
Hauptverfasser:	Hoffmann, Patrick, Hofmeister, Robert, Brischwein, Klaus, Brandl, Christian, Crommer, Sandrine, Bargou, Ralf, Itin, Christian, Prang, Nadja, Baeuerle, Patrick A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bispecific - chemistry Antigens, CD19 - biosynthesis Antineoplastic agents B-Lymphocytes - immunology Biological and medical sciences bispecific antibody CD19 CD3 CD3 Complex - biosynthesis Cell Line, Tumor Cell Membrane - metabolism Cell Nucleus - metabolism cytotoxicity Cytotoxicity, Immunologic Dose-Response Relationship, Drug Flow Cytometry General aspects Humans Immunoglobulin Fragments - chemistry Immunotherapy - methods Interleukin-2 - metabolism Kinetics Lymphocyte Activation Medical sciences Microscopy, Video Neoplasms - immunology Pharmacology. Drug treatments T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology Time Factors Tumors
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