Quantifying noise in optical tweezers by allan variance
Much effort is put into minimizing noise in optical tweezers experiments because noise and drift can mask fundamental behaviours of, e.g., single molecule assays. Various initiatives have been taken to reduce or eliminate noise but it has been difficult to quantify their effect. We propose to use Al...
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| Veröffentlicht in: | Optics express 2009-07, Vol.17 (15), p.13255-13269 |
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| container_title | Optics express |
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| creator | Czerwinski, Fabian Richardson, Andrew C Oddershede, Lene B |
| description | Much effort is put into minimizing noise in optical tweezers experiments because noise and drift can mask fundamental behaviours of, e.g., single molecule assays. Various initiatives have been taken to reduce or eliminate noise but it has been difficult to quantify their effect. We propose to use Allan variance as a simple and efficient method to quantify noise in optical tweezers setups.We apply the method to determine the optimal measurement time, frequency, and detection scheme, and quantify the effect of acoustic noise in the lab. The method can also be used on-the-fly for determining optimal parameters of running experiments. |
| doi_str_mv | 10.1364/oe.17.013255 |
| format | Article |
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| ispartof | Optics express, 2009-07, Vol.17 (15), p.13255-13269 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acoustics Calibration Equipment Design Fourier Analysis Lasers Light Magnetics Microscopy - methods Models, Statistical Monte Carlo Method Optical Tweezers Optics and Photonics Photochemistry - methods Probability Stochastic Processes |
| title | Quantifying noise in optical tweezers by allan variance |
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