Inhibition of calmodulin-dependent protein kinase II by cyclic and linear peptide alkaloids from Zizyphus species

The effects of sedative peptide alkaloids from Zizyphus species on calmodulin- dependent protein kinase II were investigated. Protein kinase II activity was assayed on the basis of its ability to activate tryptophan 5-monooxygenase as its substrate in the presence of calmodulin. All thirteen alkaloi...

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Veröffentlicht in:	Archives of pharmacal research 2005-02, Vol.28 (2), p.159-163
Hauptverfasser:	Han, Yong Nam, Hwang, Keum Hee, Han, Byung Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Brain Stem - drug effects Brain Stem - enzymology Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors In Vitro Techniques Peptides - pharmacology Rats Rats, Sprague-Dawley Structure-Activity Relationship Tryptophan Hydroxylase - metabolism Ziziphus - chemistry
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