SREBP Pathway Responds to Sterols and Functions as an Oxygen Sensor in Fission Yeast

Cholesterol and fatty acid synthesis in mammals are controlled by SREBPs, a family of membrane bound transcription factors. Our studies identified homologs of SREBP, its binding partner SCAP, and the ER retention protein Insig in Schizosaccharomyces pombe, named sre1+, scp1+, and ins1+. Like SREBP,...

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Veröffentlicht in:	Cell 2005-03, Vol.120 (6), p.831-842
Hauptverfasser:	Hughes, Adam L., Todd, Bridget L., Espenshade, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Cholesterol - biosynthesis Cricetinae Gene Expression Regulation, Fungal - physiology Microarray Analysis Oxygen - analysis Oxygen - metabolism Schizosaccharomyces - growth & development Schizosaccharomyces - metabolism Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - metabolism Transcription Factors - metabolism Transcription, Genetic
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