Systemic hypoxia alters gene expression levels of structural proteins and growth factors in knee joint cartilage

We investigated the effects of short- (8- and 24-h) and long-term (3 weeks) exposure to systemic normobaric hypoxia (13%) on the gene expression level of structural proteins and growth factors in knee joint cartilage of rabbits. Collagen type Ia2, II, and Va1, TGF-β1, and b-FGF were upregulated afte...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-05, Vol.330 (2), p.386-394
Hauptverfasser:	Hofstaetter, Jochen G., Wunderlich, Livius, Samuel, Raymond E., Saad, Fawzy A., Choi, Yeong-Hoon, Glimcher, Melvin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecan Aggrecans Animals Base Sequence Biglycan Cartilage Cartilage, Articular - metabolism Collagen Collagen - genetics Decorin DNA Primers Extracellular Matrix Proteins - genetics Gene Expression Regulation Growth Substances - genetics Hypoxia Hypoxia - genetics Knee Knee Joint - metabolism Lectins, C-Type Meniscus Proteoglycans - genetics Rabbits Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Versican
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