HDAC inhibitor-based therapies and haematological malignancy
Reversible acetylation mediated by histone deacetylase (HDAC) influences a broad repertoire of physiological processes, many of which are aberrantly controlled in tumour cells. Since HDAC inhibition prompts tumour cells to enter apoptosis, small-molecule HDAC inhibitors have been developed as a new...
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Veröffentlicht in: | Annals of oncology 2009-08, Vol.20 (8), p.1293-1302 |
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