HDAC inhibitor-based therapies and haematological malignancy

Reversible acetylation mediated by histone deacetylase (HDAC) influences a broad repertoire of physiological processes, many of which are aberrantly controlled in tumour cells. Since HDAC inhibition prompts tumour cells to enter apoptosis, small-molecule HDAC inhibitors have been developed as a new...

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Veröffentlicht in:Annals of oncology 2009-08, Vol.20 (8), p.1293-1302
Hauptverfasser: Stimson, L., Wood, V., Khan, O., Fotheringham, S., La Thangue, N.B.
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Sprache:eng
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