Selective interaction of nitric oxide synthase inhibition with phencyclidine: behavioural and NMDA receptor binding studies in the rat

The psychotomimetic drugs, phencyclidine (PCP) and MK-801, are non-competitive antagonists of the N-methyl- d-aspartate (NMDA) receptor and used as pharmacological tools to mimic a possible NMDA receptor hypofunction in schizophrenia. These drugs were tested in two behavioural paradigms in the prese...

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Veröffentlicht in:	Behavioural brain research 2005-04, Vol.159 (1), p.95-103
Hauptverfasser:	Klamer, Daniel, Zhang, Jianhua, Engel, Jörgen A., Svensson, Lennart
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Behavioral psychophysiology Biological and medical sciences Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Exploratory Behavior - drug effects Fundamental and applied biological sciences. Psychology Male MK-801 Motor Activity - drug effects Neural Inhibition - drug effects Neurotransmission and behavior NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - drug effects Phencyclidine Phencyclidine - pharmacology Prepulse inhibition Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Reflex, Startle - drug effects Schizophrenia
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