Endometriosis and Systemic Lupus Erythematosus: A Comparative Evaluation of Clinical Manifestations and Serological Autoimmune Phenomena
Problem: In view of evidences suggesting association between endometriosis (EM) and systemic lupus erythematosus (SLE), we have performed a comparative evaluation of clinical and humoral immunologic abnormalities in both diseases. Method of study: Forty‐five women (18–40 years) with histologically...
Gespeichert in:
| Veröffentlicht in: | American journal of reproductive immunology (1989) 2005-02, Vol.53 (2), p.85-93 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 93 |
|---|---|
| container_issue | 2 |
| container_start_page | 85 |
| container_title | American journal of reproductive immunology (1989) |
| container_volume | 53 |
| creator | Pasoto, Sandra G. Abrao, Mauricio S. Viana, Vilma S.T. Bueno, Cleonice Leon, Elaine P. Bonfa, Eloisa |
| description | Problem: In view of evidences suggesting association between endometriosis (EM) and systemic lupus erythematosus (SLE), we have performed a comparative evaluation of clinical and humoral immunologic abnormalities in both diseases.
Method of study: Forty‐five women (18–40 years) with histologically confirmed pelvic EM, 21 healthy‐women and 15 female SLE‐patients (18–40 years) without surgically confirmed EM were prospectively evaluated. Immunologic investigations were performed by blinded researchers.
Results: None of the EM‐patients fulfilled criteria for SLE. However, EM‐patients presented higher frequencies of arthralgia (62%) and generalized myalgia (18%) superior than normal‐controls (24%, P = 0.004/0%, P = 0.048) but comparable with SLE‐patients (33%, P = 0.052/27%, P = 0.5). Similarly to SLE (7%), 9% of EM‐patients presented fibromyalgia. Antinuclear antibodies (ANA) were detected in 18% of EM‐sera, as compared with healthy‐women (0%, P = 0.014) and SLE‐patients (93%, P = 0.0005). In contrast with SLE, antibodies to dsDNA, Sm and U1RNP were negative in EM‐sera. Anti‐Ro and anticardiolipin antibodies were more often in SLE (40%, 33%) than in EM‐patients (2%, P |
| doi_str_mv | 10.1111/j.1600-0897.2005.00252.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67554301</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67554301</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4042-89675454e5bd1b0eb712c7128c152e89b8042cf9f7b0ad755fd09cf5bdbd81703</originalsourceid><addsrcrecordid>eNqNUV1v0zAUjRAT-4C_gPzEW7LrxK4dxEtVdd1QGUgFwZvlJA5zie1ix6P9B_zsuR8ar1iyfOR7zrlX92QZwlDgdK7XBZ4A5MBrVpQAtAAoaVlsX2QXz4WXCQOZ5IwAP88uQ1gDpP-KvcrOMWU1VKS8yP7ObeeMGr12QQckbYdWuzAqo1u0jJsY0Nzvxgdl5OhCDO_RFM2c2UgvR_2o0PxRDjFBZ5Hr0WzQVrdyQJ-k1b0K46FyclXeDe7noTyNo9PGRKvQlwdlU38rX2dnvRyCenN6r7JvN_Ovs9t8-XlxN5su85YAKXNeTxgllCjadLgB1TBctunyFtNS8brhidX2dc8akB2jtO-gbvvEbjqOGVRX2buj78a73zHNKIwOrRoGaZWLQSR7SirAiciPxNa7ELzqxcZrI_1OYBD7FMRa7Jct9ssW-xTEIQWxTdK3px6xMar7JzytPRE-HAl_9KB2_20sph_vEkjy_CjXKants1z6X2n8ilHx_X4h-IKsbn6QlaDVE6cMp4M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67554301</pqid></control><display><type>article</type><title>Endometriosis and Systemic Lupus Erythematosus: A Comparative Evaluation of Clinical Manifestations and Serological Autoimmune Phenomena</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Pasoto, Sandra G. ; Abrao, Mauricio S. ; Viana, Vilma S.T. ; Bueno, Cleonice ; Leon, Elaine P. ; Bonfa, Eloisa</creator><creatorcontrib>Pasoto, Sandra G. ; Abrao, Mauricio S. ; Viana, Vilma S.T. ; Bueno, Cleonice ; Leon, Elaine P. ; Bonfa, Eloisa</creatorcontrib><description>Problem: In view of evidences suggesting association between endometriosis (EM) and systemic lupus erythematosus (SLE), we have performed a comparative evaluation of clinical and humoral immunologic abnormalities in both diseases.
Method of study: Forty‐five women (18–40 years) with histologically confirmed pelvic EM, 21 healthy‐women and 15 female SLE‐patients (18–40 years) without surgically confirmed EM were prospectively evaluated. Immunologic investigations were performed by blinded researchers.
Results: None of the EM‐patients fulfilled criteria for SLE. However, EM‐patients presented higher frequencies of arthralgia (62%) and generalized myalgia (18%) superior than normal‐controls (24%, P = 0.004/0%, P = 0.048) but comparable with SLE‐patients (33%, P = 0.052/27%, P = 0.5). Similarly to SLE (7%), 9% of EM‐patients presented fibromyalgia. Antinuclear antibodies (ANA) were detected in 18% of EM‐sera, as compared with healthy‐women (0%, P = 0.014) and SLE‐patients (93%, P = 0.0005). In contrast with SLE, antibodies to dsDNA, Sm and U1RNP were negative in EM‐sera. Anti‐Ro and anticardiolipin antibodies were more often in SLE (40%, 33%) than in EM‐patients (2%, P < 0.001/9%, P = 0.04). Elevated immune‐complexes and low total complement were more frequent in SLE (40%, 13%) compared with EM‐sera (7%, P = 0.005/0%, P = 0.01).
Conclusions: Our data indicate differences of ANA antigenic specificity and complement consumption between EM and SLE. The high prevalence of generalized musculoskeletal complaints in EM justifies a multidisciplinary approach.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/j.1600-0897.2005.00252.x</identifier><identifier>PMID: 15790342</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Antibodies, Anticardiolipin - blood ; Antibodies, Antinuclear - blood ; Arthritis - blood ; Arthritis - immunology ; Autoantibodies ; Carbonic Anhydrase II - immunology ; Complement System Proteins - immunology ; Demography ; Double-Blind Method ; endometriosis ; Endometriosis - diagnosis ; Endometriosis - immunology ; Epitopes - immunology ; Female ; fibromyalgia ; Fibromyalgia - blood ; Fibromyalgia - immunology ; Humans ; Lupus Erythematosus, Systemic - diagnosis ; Lupus Erythematosus, Systemic - immunology ; Prospective Studies ; Rheumatoid Factor - blood ; Serologic Tests ; systemic lupus erythematosus</subject><ispartof>American journal of reproductive immunology (1989), 2005-02, Vol.53 (2), p.85-93</ispartof><rights>(c) Blackwell Munksgaard, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4042-89675454e5bd1b0eb712c7128c152e89b8042cf9f7b0ad755fd09cf5bdbd81703</citedby><cites>FETCH-LOGICAL-c4042-89675454e5bd1b0eb712c7128c152e89b8042cf9f7b0ad755fd09cf5bdbd81703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0897.2005.00252.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0897.2005.00252.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15790342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pasoto, Sandra G.</creatorcontrib><creatorcontrib>Abrao, Mauricio S.</creatorcontrib><creatorcontrib>Viana, Vilma S.T.</creatorcontrib><creatorcontrib>Bueno, Cleonice</creatorcontrib><creatorcontrib>Leon, Elaine P.</creatorcontrib><creatorcontrib>Bonfa, Eloisa</creatorcontrib><title>Endometriosis and Systemic Lupus Erythematosus: A Comparative Evaluation of Clinical Manifestations and Serological Autoimmune Phenomena</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem: In view of evidences suggesting association between endometriosis (EM) and systemic lupus erythematosus (SLE), we have performed a comparative evaluation of clinical and humoral immunologic abnormalities in both diseases.
Method of study: Forty‐five women (18–40 years) with histologically confirmed pelvic EM, 21 healthy‐women and 15 female SLE‐patients (18–40 years) without surgically confirmed EM were prospectively evaluated. Immunologic investigations were performed by blinded researchers.
Results: None of the EM‐patients fulfilled criteria for SLE. However, EM‐patients presented higher frequencies of arthralgia (62%) and generalized myalgia (18%) superior than normal‐controls (24%, P = 0.004/0%, P = 0.048) but comparable with SLE‐patients (33%, P = 0.052/27%, P = 0.5). Similarly to SLE (7%), 9% of EM‐patients presented fibromyalgia. Antinuclear antibodies (ANA) were detected in 18% of EM‐sera, as compared with healthy‐women (0%, P = 0.014) and SLE‐patients (93%, P = 0.0005). In contrast with SLE, antibodies to dsDNA, Sm and U1RNP were negative in EM‐sera. Anti‐Ro and anticardiolipin antibodies were more often in SLE (40%, 33%) than in EM‐patients (2%, P < 0.001/9%, P = 0.04). Elevated immune‐complexes and low total complement were more frequent in SLE (40%, 13%) compared with EM‐sera (7%, P = 0.005/0%, P = 0.01).
Conclusions: Our data indicate differences of ANA antigenic specificity and complement consumption between EM and SLE. The high prevalence of generalized musculoskeletal complaints in EM justifies a multidisciplinary approach.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Anticardiolipin - blood</subject><subject>Antibodies, Antinuclear - blood</subject><subject>Arthritis - blood</subject><subject>Arthritis - immunology</subject><subject>Autoantibodies</subject><subject>Carbonic Anhydrase II - immunology</subject><subject>Complement System Proteins - immunology</subject><subject>Demography</subject><subject>Double-Blind Method</subject><subject>endometriosis</subject><subject>Endometriosis - diagnosis</subject><subject>Endometriosis - immunology</subject><subject>Epitopes - immunology</subject><subject>Female</subject><subject>fibromyalgia</subject><subject>Fibromyalgia - blood</subject><subject>Fibromyalgia - immunology</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Prospective Studies</subject><subject>Rheumatoid Factor - blood</subject><subject>Serologic Tests</subject><subject>systemic lupus erythematosus</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUV1v0zAUjRAT-4C_gPzEW7LrxK4dxEtVdd1QGUgFwZvlJA5zie1ix6P9B_zsuR8ar1iyfOR7zrlX92QZwlDgdK7XBZ4A5MBrVpQAtAAoaVlsX2QXz4WXCQOZ5IwAP88uQ1gDpP-KvcrOMWU1VKS8yP7ObeeMGr12QQckbYdWuzAqo1u0jJsY0Nzvxgdl5OhCDO_RFM2c2UgvR_2o0PxRDjFBZ5Hr0WzQVrdyQJ-k1b0K46FyclXeDe7noTyNo9PGRKvQlwdlU38rX2dnvRyCenN6r7JvN_Ovs9t8-XlxN5su85YAKXNeTxgllCjadLgB1TBctunyFtNS8brhidX2dc8akB2jtO-gbvvEbjqOGVRX2buj78a73zHNKIwOrRoGaZWLQSR7SirAiciPxNa7ELzqxcZrI_1OYBD7FMRa7Jct9ssW-xTEIQWxTdK3px6xMar7JzytPRE-HAl_9KB2_20sph_vEkjy_CjXKants1z6X2n8ilHx_X4h-IKsbn6QlaDVE6cMp4M</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Pasoto, Sandra G.</creator><creator>Abrao, Mauricio S.</creator><creator>Viana, Vilma S.T.</creator><creator>Bueno, Cleonice</creator><creator>Leon, Elaine P.</creator><creator>Bonfa, Eloisa</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Endometriosis and Systemic Lupus Erythematosus: A Comparative Evaluation of Clinical Manifestations and Serological Autoimmune Phenomena</title><author>Pasoto, Sandra G. ; Abrao, Mauricio S. ; Viana, Vilma S.T. ; Bueno, Cleonice ; Leon, Elaine P. ; Bonfa, Eloisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4042-89675454e5bd1b0eb712c7128c152e89b8042cf9f7b0ad755fd09cf5bdbd81703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies, Anticardiolipin - blood</topic><topic>Antibodies, Antinuclear - blood</topic><topic>Arthritis - blood</topic><topic>Arthritis - immunology</topic><topic>Autoantibodies</topic><topic>Carbonic Anhydrase II - immunology</topic><topic>Complement System Proteins - immunology</topic><topic>Demography</topic><topic>Double-Blind Method</topic><topic>endometriosis</topic><topic>Endometriosis - diagnosis</topic><topic>Endometriosis - immunology</topic><topic>Epitopes - immunology</topic><topic>Female</topic><topic>fibromyalgia</topic><topic>Fibromyalgia - blood</topic><topic>Fibromyalgia - immunology</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Prospective Studies</topic><topic>Rheumatoid Factor - blood</topic><topic>Serologic Tests</topic><topic>systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pasoto, Sandra G.</creatorcontrib><creatorcontrib>Abrao, Mauricio S.</creatorcontrib><creatorcontrib>Viana, Vilma S.T.</creatorcontrib><creatorcontrib>Bueno, Cleonice</creatorcontrib><creatorcontrib>Leon, Elaine P.</creatorcontrib><creatorcontrib>Bonfa, Eloisa</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pasoto, Sandra G.</au><au>Abrao, Mauricio S.</au><au>Viana, Vilma S.T.</au><au>Bueno, Cleonice</au><au>Leon, Elaine P.</au><au>Bonfa, Eloisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endometriosis and Systemic Lupus Erythematosus: A Comparative Evaluation of Clinical Manifestations and Serological Autoimmune Phenomena</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2005-02</date><risdate>2005</risdate><volume>53</volume><issue>2</issue><spage>85</spage><epage>93</epage><pages>85-93</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem: In view of evidences suggesting association between endometriosis (EM) and systemic lupus erythematosus (SLE), we have performed a comparative evaluation of clinical and humoral immunologic abnormalities in both diseases.
Method of study: Forty‐five women (18–40 years) with histologically confirmed pelvic EM, 21 healthy‐women and 15 female SLE‐patients (18–40 years) without surgically confirmed EM were prospectively evaluated. Immunologic investigations were performed by blinded researchers.
Results: None of the EM‐patients fulfilled criteria for SLE. However, EM‐patients presented higher frequencies of arthralgia (62%) and generalized myalgia (18%) superior than normal‐controls (24%, P = 0.004/0%, P = 0.048) but comparable with SLE‐patients (33%, P = 0.052/27%, P = 0.5). Similarly to SLE (7%), 9% of EM‐patients presented fibromyalgia. Antinuclear antibodies (ANA) were detected in 18% of EM‐sera, as compared with healthy‐women (0%, P = 0.014) and SLE‐patients (93%, P = 0.0005). In contrast with SLE, antibodies to dsDNA, Sm and U1RNP were negative in EM‐sera. Anti‐Ro and anticardiolipin antibodies were more often in SLE (40%, 33%) than in EM‐patients (2%, P < 0.001/9%, P = 0.04). Elevated immune‐complexes and low total complement were more frequent in SLE (40%, 13%) compared with EM‐sera (7%, P = 0.005/0%, P = 0.01).
Conclusions: Our data indicate differences of ANA antigenic specificity and complement consumption between EM and SLE. The high prevalence of generalized musculoskeletal complaints in EM justifies a multidisciplinary approach.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15790342</pmid><doi>10.1111/j.1600-0897.2005.00252.x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2005-02, Vol.53 (2), p.85-93 |
| issn | 1046-7408 1600-0897 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67554301 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Adult Antibodies, Anticardiolipin - blood Antibodies, Antinuclear - blood Arthritis - blood Arthritis - immunology Autoantibodies Carbonic Anhydrase II - immunology Complement System Proteins - immunology Demography Double-Blind Method endometriosis Endometriosis - diagnosis Endometriosis - immunology Epitopes - immunology Female fibromyalgia Fibromyalgia - blood Fibromyalgia - immunology Humans Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - immunology Prospective Studies Rheumatoid Factor - blood Serologic Tests systemic lupus erythematosus |
| title | Endometriosis and Systemic Lupus Erythematosus: A Comparative Evaluation of Clinical Manifestations and Serological Autoimmune Phenomena |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T20%3A58%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endometriosis%20and%20Systemic%20Lupus%20Erythematosus:%20A%20Comparative%20Evaluation%20of%20Clinical%20Manifestations%20and%20Serological%20Autoimmune%20Phenomena&rft.jtitle=American%20journal%20of%20reproductive%20immunology%20(1989)&rft.au=Pasoto,%20Sandra%20G.&rft.date=2005-02&rft.volume=53&rft.issue=2&rft.spage=85&rft.epage=93&rft.pages=85-93&rft.issn=1046-7408&rft.eissn=1600-0897&rft_id=info:doi/10.1111/j.1600-0897.2005.00252.x&rft_dat=%3Cproquest_cross%3E67554301%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67554301&rft_id=info:pmid/15790342&rfr_iscdi=true |