A Src family inhibitor (PP1) potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells

Connexin (Cx) genes exert negative growth effects on tumor cells with certain cell specificity. We have recently reported that Cx32 acts as a tumor suppressor gene in renal cancer cells due to the inhibition of Src-dependent signaling. In line with the previous study, here we examined if a Src famil...

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Veröffentlicht in:	Life sciences (1973) 2005-04, Vol.76 (23), p.2711-2720
Hauptverfasser:	Fujimoto, Eriko, Sato, Hiromi, Nagashima, Yoji, Negishi, Etsuko, Shirai, Sumiko, Fukumoto, Keiko, Hagiwara, Hiromi, Hagiwara, Kiyokazu, Ueno, Koichi, Yano, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects bcl-X Protein Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - prevention & control Cell Cycle Cell Proliferation Combined Modality Therapy Connexin 32 Connexins - genetics Connexins - metabolism Gap Junction beta-1 Protein Humans Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidney Neoplasms - prevention & control Mice Mice, Inbred BALB C Mice, Nude PP1 Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrazoles - therapeutic use Pyrimidines - therapeutic use Renal cancer cell Src src-Family Kinases - antagonists & inhibitors Transfection Transplantation, Heterologous Tumor Cells, Cultured Tumor suppressor gene
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