Memory antibody response from antigen loaded polymer particles and the effect of antigen release kinetics

Abstract Memory antibody response is the hallmark of long lasting immunity. In this study, we report the generation of memory antibody response while immunizing with single dose of polymer particle entrapped antigens. Immunization with admixture of alum and polylactide (PLA) polymer particles (2–8 μ...

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Veröffentlicht in:	Biomaterials 2009-09, Vol.30 (27), p.4763-4776
Hauptverfasser:	Kanchan, Vibhu, Katare, Yogesh K, Panda, Amulya K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Advanced Basic Science Animals Antibody Formation - immunology Antibody Specificity - immunology Antigens - administration & dosage Antigens - immunology B-Lymphocytes - immunology Dentistry Diphtheria Toxoid - immunology Epitopes - immunology Female Immunization Immunologic Memory - immunology Kinetics Memory antibody response Release profile of antigen Microparticles Models, Immunological Nanoparticles - ultrastructure Polyesters - metabolism Polylactide Porosity Rats Rats, Wistar Surface Properties Tetanus Toxoid - immunology Time Factors Vaccine delivery
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