Platelet Activation Markers in Patients With Heart Assist Device

: Clinical use of heart assist devices is often associated with thromboembolic complications. We hypothesized that platelets may be activated in patients receiving assist devices and examined expression of the platelet activation markers CD62, CD63, and thrombospondin using flow cytometry in eight...

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Veröffentlicht in:	Artificial organs 2005-04, Vol.29 (4), p.292-299
Hauptverfasser:	Dewald, Oliver, Schmitz, Christoph, Diem, Heinz, Goehring, Peter, Vetter, Herbert Otto, Roell, Wilhelm, Goedje, Oliver, Tschoepe, Diethelm, Reichart, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticoagulants Antigens, CD - blood Cell-adhesion molecules Child Female Flow cytometry Heart assist device Heart Failure - blood Heart Failure - physiopathology Heart Failure - therapy Heart-Assist Devices - adverse effects Humans Male Middle Aged P-Selectin - blood Platelet Membrane Glycoproteins Platelets Postoperative Hemorrhage - etiology Tetraspanin 30 Thromboembolism - etiology Thrombospondins - blood Time Factors Treatment Outcome
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Zusammenfassung:	: Clinical use of heart assist devices is often associated with thromboembolic complications. We hypothesized that platelets may be activated in patients receiving assist devices and examined expression of the platelet activation markers CD62, CD63, and thrombospondin using flow cytometry in eight patients with Novacor left ventricular assist system (LVAS) or Berlin Heart. Patients with end‐stage heart failure had elevated expression of platelet activation markers before insertion of the assist device. While CD62 (P
ISSN:	0160-564X 1525-1594
DOI:	10.1111/j.1525-1594.2005.29050.x