Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys
The objective was to study dynamic changes of ovaries in rhesus macaques stimulated by gonadotropins to identify an indicator for predicting ovarian response to stimulation. Twenty-one cycling monkeys were given 36 IU/d recombinant human follicle-stimulating hormone (rhFSH) for 8 d. Animals (n = 17)...
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| Veröffentlicht in: | Theriogenology 2009-09, Vol.72 (4), p.560-565 |
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| container_title | Theriogenology |
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| creator | Yang, S. He, X. Niu, Y. Wang, X. Lu, B. Hildebrandt, T.B. Goeritz, F. Jewgenow, K. Zhou, Q. Ji, W. |
| description | The objective was to study dynamic changes of ovaries in rhesus macaques stimulated by gonadotropins to identify an indicator for predicting ovarian response to stimulation. Twenty-one cycling monkeys were given 36 IU/d recombinant human follicle-stimulating hormone (rhFSH) for 8 d. Animals (n
=
17) with ≥5 follicles (≥3
mm) in their ovaries on Day 9 of ovarian stimulation were deemed good responders, whereas those with a lesser response were poor responders (n
=
4). For these two groups, the mean (±SD) numbers of oocytes retrieved were 44.3
±
21.4 and 11.0
±
4.6, respectively. In retrospect, the mean diameters of the ovaries and of the largest follicles, the total number of detectable follicles (diameter >0.5
mm), and serum estradiol concentrations gradually increased during the stimulation period in the good responders but did not increase in the poor responders. Comparing good and poor responders, the number of ovarian follicles >0.5
mm already exhibited a difference (12.9
±
6.5 vs. 2.9
±
1.3, respectively, P
<
0.05) on Day 1 of stimulation. However, for other end points, differences were not significant until at least Day 5. Moreover, good responders yielded a fivefold higher blastocyst development rate than that of poor responders (P
<
0.01). In conclusion, the number of ovarian follicles detected with ultrasonography could be useful to predict the response to FSH stimulation in non-human primates. |
| doi_str_mv | 10.1016/j.theriogenology.2009.04.012 |
| format | Article |
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=
17) with ≥5 follicles (≥3
mm) in their ovaries on Day 9 of ovarian stimulation were deemed good responders, whereas those with a lesser response were poor responders (n
=
4). For these two groups, the mean (±SD) numbers of oocytes retrieved were 44.3
±
21.4 and 11.0
±
4.6, respectively. In retrospect, the mean diameters of the ovaries and of the largest follicles, the total number of detectable follicles (diameter >0.5
mm), and serum estradiol concentrations gradually increased during the stimulation period in the good responders but did not increase in the poor responders. Comparing good and poor responders, the number of ovarian follicles >0.5
mm already exhibited a difference (12.9
±
6.5 vs. 2.9
±
1.3, respectively, P
<
0.05) on Day 1 of stimulation. However, for other end points, differences were not significant until at least Day 5. Moreover, good responders yielded a fivefold higher blastocyst development rate than that of poor responders (P
<
0.01). In conclusion, the number of ovarian follicles detected with ultrasonography could be useful to predict the response to FSH stimulation in non-human primates.</description><identifier>ISSN: 0093-691X</identifier><identifier>EISSN: 1879-3231</identifier><identifier>DOI: 10.1016/j.theriogenology.2009.04.012</identifier><identifier>PMID: 19501391</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; blastocyst ; cell cleavage ; embryogenesis ; estradiol ; Female ; Follicle Stimulating Hormone - pharmacology ; follicle-stimulating hormone ; follicular development ; gonadotropin-releasing hormone ; Gonadotropins - pharmacology ; Humans ; laboratory animals ; Macaca mulatta ; Macaca mulatta - anatomy & histology ; Ovarian follicle ; Ovarian Follicle - diagnostic imaging ; Ovarian Follicle - drug effects ; ovarian follicles ; Ovarian stimulation ; ovaries ; ovulation ; Primate ; Recombinant Fusion Proteins - pharmacology ; Rhesus monkey ; Ultrasonography</subject><ispartof>Theriogenology, 2009-09, Vol.72 (4), p.560-565</ispartof><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-554f8c6c874132e9d550d9946bfd9c166aa0cd9debeebfafb5c74cde04a355893</citedby><cites>FETCH-LOGICAL-c408t-554f8c6c874132e9d550d9946bfd9c166aa0cd9debeebfafb5c74cde04a355893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.theriogenology.2009.04.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19501391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, S.</creatorcontrib><creatorcontrib>He, X.</creatorcontrib><creatorcontrib>Niu, Y.</creatorcontrib><creatorcontrib>Wang, X.</creatorcontrib><creatorcontrib>Lu, B.</creatorcontrib><creatorcontrib>Hildebrandt, T.B.</creatorcontrib><creatorcontrib>Goeritz, F.</creatorcontrib><creatorcontrib>Jewgenow, K.</creatorcontrib><creatorcontrib>Zhou, Q.</creatorcontrib><creatorcontrib>Ji, W.</creatorcontrib><title>Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys</title><title>Theriogenology</title><addtitle>Theriogenology</addtitle><description>The objective was to study dynamic changes of ovaries in rhesus macaques stimulated by gonadotropins to identify an indicator for predicting ovarian response to stimulation. Twenty-one cycling monkeys were given 36 IU/d recombinant human follicle-stimulating hormone (rhFSH) for 8 d. Animals (n
=
17) with ≥5 follicles (≥3
mm) in their ovaries on Day 9 of ovarian stimulation were deemed good responders, whereas those with a lesser response were poor responders (n
=
4). For these two groups, the mean (±SD) numbers of oocytes retrieved were 44.3
±
21.4 and 11.0
±
4.6, respectively. In retrospect, the mean diameters of the ovaries and of the largest follicles, the total number of detectable follicles (diameter >0.5
mm), and serum estradiol concentrations gradually increased during the stimulation period in the good responders but did not increase in the poor responders. Comparing good and poor responders, the number of ovarian follicles >0.5
mm already exhibited a difference (12.9
±
6.5 vs. 2.9
±
1.3, respectively, P
<
0.05) on Day 1 of stimulation. However, for other end points, differences were not significant until at least Day 5. Moreover, good responders yielded a fivefold higher blastocyst development rate than that of poor responders (P
<
0.01). In conclusion, the number of ovarian follicles detected with ultrasonography could be useful to predict the response to FSH stimulation in non-human primates.</description><subject>Animals</subject><subject>blastocyst</subject><subject>cell cleavage</subject><subject>embryogenesis</subject><subject>estradiol</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - pharmacology</subject><subject>follicle-stimulating hormone</subject><subject>follicular development</subject><subject>gonadotropin-releasing hormone</subject><subject>Gonadotropins - pharmacology</subject><subject>Humans</subject><subject>laboratory animals</subject><subject>Macaca mulatta</subject><subject>Macaca mulatta - anatomy & histology</subject><subject>Ovarian follicle</subject><subject>Ovarian Follicle - diagnostic imaging</subject><subject>Ovarian Follicle - drug effects</subject><subject>ovarian follicles</subject><subject>Ovarian stimulation</subject><subject>ovaries</subject><subject>ovulation</subject><subject>Primate</subject><subject>Recombinant Fusion Proteins - pharmacology</subject><subject>Rhesus monkey</subject><subject>Ultrasonography</subject><issn>0093-691X</issn><issn>1879-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2L1DAYgIMo7rj6F7QH8daaNB9twIvsuioseNAFbyFN3nYypsmYtAv992aYAfHmKZD3eZ-EB6G3BDcEE_H-0Cx7SC5OEKKP09a0GMsGswaT9gnakb6TNW0peYp2ZUBrIcnPK_Qi5wPGmApBnqMrIjkmVJIdSrdb0LMzldnrMEGuXKjio05Oh2qM3jvjy-UMOq8JbDVs1eqXpHMMcUr6uN8quyYXpmqKQdu4pHgshry4efV6cTGchGkPeS2WGH7Bll-iZ6P2GV5dzmv0cPfpx82X-v7b5683H-9rw3C_1JyzsTfC9B0jtAVpOcdWSiaG0UpDhNAaGystDADDqMeBm44ZC5hpynkv6TV6d_YeU_y9Ql7U7LIB73WAuGYlOs76tusK-OEMmhRzTjCqY3KzTpsiWJ2aq4P6t7k6NVeYqdK8rL--vLMOM9i_y5fIBXhzBkYdlZ6Sy-rhe1tmRS0Ypifi7kxA6fHoIKlsHAQD1iUwi7LR_d9f_gCM86m0</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Yang, S.</creator><creator>He, X.</creator><creator>Niu, Y.</creator><creator>Wang, X.</creator><creator>Lu, B.</creator><creator>Hildebrandt, T.B.</creator><creator>Goeritz, F.</creator><creator>Jewgenow, K.</creator><creator>Zhou, Q.</creator><creator>Ji, W.</creator><general>Elsevier Inc</general><general>[Oxford]: Butterworth-Heinemann; [New York]: Elsevier Science</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys</title><author>Yang, S. ; He, X. ; Niu, Y. ; Wang, X. ; Lu, B. ; Hildebrandt, T.B. ; Goeritz, F. ; Jewgenow, K. ; Zhou, Q. ; Ji, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-554f8c6c874132e9d550d9946bfd9c166aa0cd9debeebfafb5c74cde04a355893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>blastocyst</topic><topic>cell cleavage</topic><topic>embryogenesis</topic><topic>estradiol</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - pharmacology</topic><topic>follicle-stimulating hormone</topic><topic>follicular development</topic><topic>gonadotropin-releasing hormone</topic><topic>Gonadotropins - pharmacology</topic><topic>Humans</topic><topic>laboratory animals</topic><topic>Macaca mulatta</topic><topic>Macaca mulatta - anatomy & histology</topic><topic>Ovarian follicle</topic><topic>Ovarian Follicle - diagnostic imaging</topic><topic>Ovarian Follicle - drug effects</topic><topic>ovarian follicles</topic><topic>Ovarian stimulation</topic><topic>ovaries</topic><topic>ovulation</topic><topic>Primate</topic><topic>Recombinant Fusion Proteins - pharmacology</topic><topic>Rhesus monkey</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, S.</creatorcontrib><creatorcontrib>He, X.</creatorcontrib><creatorcontrib>Niu, Y.</creatorcontrib><creatorcontrib>Wang, X.</creatorcontrib><creatorcontrib>Lu, B.</creatorcontrib><creatorcontrib>Hildebrandt, T.B.</creatorcontrib><creatorcontrib>Goeritz, F.</creatorcontrib><creatorcontrib>Jewgenow, K.</creatorcontrib><creatorcontrib>Zhou, Q.</creatorcontrib><creatorcontrib>Ji, W.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Theriogenology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, S.</au><au>He, X.</au><au>Niu, Y.</au><au>Wang, X.</au><au>Lu, B.</au><au>Hildebrandt, T.B.</au><au>Goeritz, F.</au><au>Jewgenow, K.</au><au>Zhou, Q.</au><au>Ji, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys</atitle><jtitle>Theriogenology</jtitle><addtitle>Theriogenology</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>72</volume><issue>4</issue><spage>560</spage><epage>565</epage><pages>560-565</pages><issn>0093-691X</issn><eissn>1879-3231</eissn><abstract>The objective was to study dynamic changes of ovaries in rhesus macaques stimulated by gonadotropins to identify an indicator for predicting ovarian response to stimulation. Twenty-one cycling monkeys were given 36 IU/d recombinant human follicle-stimulating hormone (rhFSH) for 8 d. Animals (n
=
17) with ≥5 follicles (≥3
mm) in their ovaries on Day 9 of ovarian stimulation were deemed good responders, whereas those with a lesser response were poor responders (n
=
4). For these two groups, the mean (±SD) numbers of oocytes retrieved were 44.3
±
21.4 and 11.0
±
4.6, respectively. In retrospect, the mean diameters of the ovaries and of the largest follicles, the total number of detectable follicles (diameter >0.5
mm), and serum estradiol concentrations gradually increased during the stimulation period in the good responders but did not increase in the poor responders. Comparing good and poor responders, the number of ovarian follicles >0.5
mm already exhibited a difference (12.9
±
6.5 vs. 2.9
±
1.3, respectively, P
<
0.05) on Day 1 of stimulation. However, for other end points, differences were not significant until at least Day 5. Moreover, good responders yielded a fivefold higher blastocyst development rate than that of poor responders (P
<
0.01). In conclusion, the number of ovarian follicles detected with ultrasonography could be useful to predict the response to FSH stimulation in non-human primates.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19501391</pmid><doi>10.1016/j.theriogenology.2009.04.012</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0093-691X |
| ispartof | Theriogenology, 2009-09, Vol.72 (4), p.560-565 |
| issn | 0093-691X 1879-3231 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67548277 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals blastocyst cell cleavage embryogenesis estradiol Female Follicle Stimulating Hormone - pharmacology follicle-stimulating hormone follicular development gonadotropin-releasing hormone Gonadotropins - pharmacology Humans laboratory animals Macaca mulatta Macaca mulatta - anatomy & histology Ovarian follicle Ovarian Follicle - diagnostic imaging Ovarian Follicle - drug effects ovarian follicles Ovarian stimulation ovaries ovulation Primate Recombinant Fusion Proteins - pharmacology Rhesus monkey Ultrasonography |
| title | Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys |
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