Inhibitory activity of polyhydroxycarboxylate chelators against recombinant NF-kappaB p50 protein-DNA binding

The inhibitory effect of 7,8-dihydroxy-4-methylcoumarin (7,8-DHMC), 5,7-dihydroxy-4-methylcoumarin (5,7-DHMC), and gallic acid on the DNA binding of recombinant p50 protein and their interaction with zinc ion were studied. Electrophoretic mobility shift assay (EMSA) using p50 and biotin labeled DNA...

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Veröffentlicht in:	Bioorganic chemistry 2005-04, Vol.33 (2), p.67-81
Hauptverfasser:	Sharma, Rakesh K, Pande, Vineet, Ramos, Maria J, Rajor, Hament K, Chopra, Shilpa, Meguro, Kazuyuki, Inoue, Jun-ichiro, Otsuka, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	Cations, Divalent Chelating Agents - pharmacology Coumarins - pharmacology DNA - chemistry DNA - metabolism Gallic Acid - pharmacology Models, Molecular Molecular Structure NF-kappa B p50 Subunit - antagonists & inhibitors NF-kappa B p50 Subunit - metabolism Protein Binding - drug effects Umbelliferones - pharmacology Zinc - chemistry
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