Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: Association to tumor derived alpha-N-acetylgalactosaminidase activity

Abstract Currently clinical outcome in melanoma is not predictable by known serum biomarkers. The only reliable tool for the diagnosis of this tumor is the histopathological assay after surgical removing. We used a proteomic approach in order to identify novel non-invasive serum biomarkers of melano...

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Veröffentlicht in:	Cancer letters 2009-10, Vol.283 (2), p.222-229
Hauptverfasser:	Greco, Marilena, Mitri, Marianna De, Chiriacò, Fernanda, Leo, Giuseppe, Brienza, Ettore, Maffia, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alpha-N-acetylgalactosaminidase alpha-N-Acetylgalactosaminidase - blood Biomarkers Biomarkers, Tumor - blood Disease Progression Electrophoresis, Gel, Two-Dimensional Hematology, Oncology and Palliative Medicine Humans MALDI-TOF Medical prognosis Medical research Melanoma Melanoma - blood Melanoma - enzymology Melanoma - pathology Neoplasm Staging Proteins Proteomics Serum proteomics Skin cancer Skin Neoplasms - blood Skin Neoplasms - enzymology Skin Neoplasms - pathology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Surgery Two-dimensional electrophoresis
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