The induction of cell alignment by covalently immobilized gradients of the 6th Ig-like domain of cell adhesion molecule L1 in 3D-fibrin matrices

Abstract Concentration gradients of matrix-bound guidance cues in the extracellular matrix direct cell growth in native tissues and are of great interest for the design of biomedical scaffolds and on implant surfaces. This study describes effects of covalently immobilized gradients of the 6th Ig-lik...

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Veröffentlicht in:	Biomaterials 2009-09, Vol.30 (27), p.4503-4512
Hauptverfasser:	Lühmann, Tessa, Hänseler, Patrick, Grant, Barbara, Hall, Heike
Format:	Artikel
Sprache:	eng
Schlagworte:	3D-fibrin matrices Advanced Basic Science Animals Cattle Cell alignment Cell guidance cues Cell Line Cell Movement - drug effects Covalent gradients Dentistry Extracellular Matrix - metabolism Fibrin - pharmacology Fibroblasts - cytology Fibroblasts - drug effects Humans Immobilized Proteins - pharmacology Immunoglobulins - chemistry Neural Cell Adhesion Molecule L1 - chemistry Neural Cell Adhesion Molecule L1 - pharmacology Protein Stability - drug effects Protein Structure, Tertiary Recombinant Fusion Proteins - pharmacology Serum Albumin, Bovine - metabolism Solubility - drug effects TG-L1Ig6 Transglutaminases - metabolism
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