Lipid-mediated delivery of brain-specific angiogenesis inhibitor 1 gene reduces corneal neovascularization in an in vivo rabbit model

Corneal neovascularization, which occurs in many pathologic states of the cornea, reduces the visual acuity. Recently, we found that the extracellular region of brain-specific angiogenesis inhibitor 1 (BAI1-ECR) has antiproliferative activity through functional blocking of alpha(v)beta(5) integrin i...

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Veröffentlicht in:	Gene therapy 2005-04, Vol.12 (7), p.617-624
Hauptverfasser:	YOON, K. C, AHN, K. Y, LEE, J. H, CHUN, B. J, PARK, S. W, SEO, M. S, PARK, Y.-G, KIM, K. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Angiogenesis inhibitors Angiogenic Proteins - genetics Angiogenic Proteins - metabolism Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Care and treatment Cell differentiation, maturation, development, hematopoiesis Cell physiology Cornea Cornea - metabolism Corneal diseases Corneal Neovascularization - metabolism Corneal Neovascularization - pathology Corneal Neovascularization - therapy Debridement Disease Models, Animal Dosage and administration EcR protein Endothelial cells Eye Fundamental and applied biological sciences. Psychology Gene therapy Gene transfer Gene Transfer Techniques Genes, Reporter Genetic aspects Genetic Therapy - methods Genetic Vectors - administration & dosage Health aspects Health. Pharmaceutical industry Immunotherapy - methods Industrial applications and implications. Economical aspects Integrins - immunology Lipids Medical sciences Methods Molecular and cellular biology Rabbits Receptors, Vitronectin - immunology Stroma Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vascular endothelial growth factor Vascular Endothelial Growth Factor A - immunology Vascular Endothelial Growth Factor A - metabolism Vascularization
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