A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients
Background Treatment options remain unsatisfactory for patients with palmoplantar psoriasis (PP) and palmoplantar pustular psoriasis (PPP). Aim To evaluate the therapeutic responses of PP and PPP patients that were treated in our psoriasis polyclinic between 2003 and 2007. Methods This retrospect...
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Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2009-07, Vol.23 (7), p.814-819 |
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description | Background Treatment options remain unsatisfactory for patients with palmoplantar psoriasis (PP) and palmoplantar pustular psoriasis (PPP).
Aim To evaluate the therapeutic responses of PP and PPP patients that were treated in our psoriasis polyclinic between 2003 and 2007.
Methods This retrospective study comprised PP (n = 62) and PPP (n = 52) patients. Treatments were individualized according to patient compliance and associating systemic diseases. The effect of systemic treatments was grouped as follows: ‘no improvement’: patients unresponsive for the present treatment; ‘partial improvement’: 75% decrease of the disease compared to baseline.
Results In the PP group, 17 of 62 patients showed marked improvement to topical agents, while the remaining patients required systemic agents including oral retinoids (n = 24), local psoralen plus ultraviolet A (PUVA; n = 12), methotrexate (n = 9) and cyclosporine (n = 2). Marked improvement was achieved in 53%, 45%, 47% and 100%, respectively. In these patients, two (n = 10), three (n = 5), or four (n = 5) systemic agents were used alternately.
In the PPP group, 18 of 52 patients achieved marked improvement by topical agents. Patients that required systemic agents were treated with colchicum (n = 19), local PUVA (n = 8), methotrexate (n = 4), oral retinoids (n = 3) and cyclosporine (n = 2). These treatments achieved a marked improvement in 60%, 33%, 57%, 83%, and 50% of the patients, respectively. In the course of the disease, 18 patients required two and 3 patients required three systemic agents alternately.
Conclusions Although the success rates appeared to be high, the high number of patients who required multiple systemic agents emphasized the fact that localized forms of psoriasis were resistant to therapy.
Conflicts of interest
None declared |
doi_str_mv | 10.1111/j.1468-3083.2009.03197.x |
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fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67547183</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20069172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5027-191d0e595aa9273458976db3e9c97480f87e1d90546a1e3349dfdbc201b3e9923</originalsourceid><addsrcrecordid>eNqNkE1v1DAQhi0EokvhL6CcuCX1xHGcOXCottBSraBCfAguljeZSF7yVdvb7v57nO6qHKkvtjzvM2M_jCXAM4jrbJNBUVap4JXIcs4x4wJQZbtnbPFYeM4WHPMyRZR4wl55v-GcA8jqJTsBLBTnpViwX-eJo-BGP1Ed7B0lZjDd3lufjG0SHJnQ0xBixk_j4OnhejJdP06dGYJxyeRHZ80M2CEBKGI12Ij41-xFazpPb477Kfv-8cO35VW6-nL5aXm-SmvJc5UCQsNJojQGcyUKWaEqm7UgrFEVFW8rRdAgl0VpgIQosGmbdZ1zmDOYi1P27tB3cuPtlnzQvfU1dfF9NG69LpUsFFTiv8EoskRQc8fqEKyjF--o1ZOzvXF7DVzP_vVGz5r1rHnGUD_417uIvj3O2K57av6BR-Ex8P4QuLcd7Z_cWF9f_JhPkU8PvPWBdo-8cX_iR4WS-ufnS728XqrfX1cX-kb8BcrVov0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20069172</pqid></control><display><type>article</type><title>A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Adışen, E ; Tekin, O ; Gülekon, A ; Gürer, MA</creator><creatorcontrib>Adışen, E ; Tekin, O ; Gülekon, A ; Gürer, MA</creatorcontrib><description>Background Treatment options remain unsatisfactory for patients with palmoplantar psoriasis (PP) and palmoplantar pustular psoriasis (PPP).
Aim To evaluate the therapeutic responses of PP and PPP patients that were treated in our psoriasis polyclinic between 2003 and 2007.
Methods This retrospective study comprised PP (n = 62) and PPP (n = 52) patients. Treatments were individualized according to patient compliance and associating systemic diseases. The effect of systemic treatments was grouped as follows: ‘no improvement’: patients unresponsive for the present treatment; ‘partial improvement’: < 50% decrease in severity or affected area; ‘moderate improvement’: 50–75% decrease in severity or affected area, and ‘marked improvement’: > 75% decrease of the disease compared to baseline.
Results In the PP group, 17 of 62 patients showed marked improvement to topical agents, while the remaining patients required systemic agents including oral retinoids (n = 24), local psoralen plus ultraviolet A (PUVA; n = 12), methotrexate (n = 9) and cyclosporine (n = 2). Marked improvement was achieved in 53%, 45%, 47% and 100%, respectively. In these patients, two (n = 10), three (n = 5), or four (n = 5) systemic agents were used alternately.
In the PPP group, 18 of 52 patients achieved marked improvement by topical agents. Patients that required systemic agents were treated with colchicum (n = 19), local PUVA (n = 8), methotrexate (n = 4), oral retinoids (n = 3) and cyclosporine (n = 2). These treatments achieved a marked improvement in 60%, 33%, 57%, 83%, and 50% of the patients, respectively. In the course of the disease, 18 patients required two and 3 patients required three systemic agents alternately.
Conclusions Although the success rates appeared to be high, the high number of patients who required multiple systemic agents emphasized the fact that localized forms of psoriasis were resistant to therapy.
Conflicts of interest
None declared</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/j.1468-3083.2009.03197.x</identifier><identifier>PMID: 19470063</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Child ; Colchicum ; Cyclosporine - therapeutic use ; cyclosporine and retinoids ; Female ; Humans ; Keratoderma, Palmoplantar - drug therapy ; Male ; methotrexate ; Methotrexate - therapeutic use ; Middle Aged ; palmoplantar psoriasis ; palmoplantar pustular psoriasis ; Photochemotherapy ; Psoriasis - drug therapy ; PUVA ; Retinoids - therapeutic use ; Retrospective Studies ; systemic treatment ; topical corticosteroids ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2009-07, Vol.23 (7), p.814-819</ispartof><rights>2009 The Authors. Journal compilation © 2009 European Academy of Dermatology and Venereology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5027-191d0e595aa9273458976db3e9c97480f87e1d90546a1e3349dfdbc201b3e9923</citedby><cites>FETCH-LOGICAL-c5027-191d0e595aa9273458976db3e9c97480f87e1d90546a1e3349dfdbc201b3e9923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-3083.2009.03197.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-3083.2009.03197.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19470063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adışen, E</creatorcontrib><creatorcontrib>Tekin, O</creatorcontrib><creatorcontrib>Gülekon, A</creatorcontrib><creatorcontrib>Gürer, MA</creatorcontrib><title>A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background Treatment options remain unsatisfactory for patients with palmoplantar psoriasis (PP) and palmoplantar pustular psoriasis (PPP).
Aim To evaluate the therapeutic responses of PP and PPP patients that were treated in our psoriasis polyclinic between 2003 and 2007.
Methods This retrospective study comprised PP (n = 62) and PPP (n = 52) patients. Treatments were individualized according to patient compliance and associating systemic diseases. The effect of systemic treatments was grouped as follows: ‘no improvement’: patients unresponsive for the present treatment; ‘partial improvement’: < 50% decrease in severity or affected area; ‘moderate improvement’: 50–75% decrease in severity or affected area, and ‘marked improvement’: > 75% decrease of the disease compared to baseline.
Results In the PP group, 17 of 62 patients showed marked improvement to topical agents, while the remaining patients required systemic agents including oral retinoids (n = 24), local psoralen plus ultraviolet A (PUVA; n = 12), methotrexate (n = 9) and cyclosporine (n = 2). Marked improvement was achieved in 53%, 45%, 47% and 100%, respectively. In these patients, two (n = 10), three (n = 5), or four (n = 5) systemic agents were used alternately.
In the PPP group, 18 of 52 patients achieved marked improvement by topical agents. Patients that required systemic agents were treated with colchicum (n = 19), local PUVA (n = 8), methotrexate (n = 4), oral retinoids (n = 3) and cyclosporine (n = 2). These treatments achieved a marked improvement in 60%, 33%, 57%, 83%, and 50% of the patients, respectively. In the course of the disease, 18 patients required two and 3 patients required three systemic agents alternately.
Conclusions Although the success rates appeared to be high, the high number of patients who required multiple systemic agents emphasized the fact that localized forms of psoriasis were resistant to therapy.
Conflicts of interest
None declared</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Child</subject><subject>Colchicum</subject><subject>Cyclosporine - therapeutic use</subject><subject>cyclosporine and retinoids</subject><subject>Female</subject><subject>Humans</subject><subject>Keratoderma, Palmoplantar - drug therapy</subject><subject>Male</subject><subject>methotrexate</subject><subject>Methotrexate - therapeutic use</subject><subject>Middle Aged</subject><subject>palmoplantar psoriasis</subject><subject>palmoplantar pustular psoriasis</subject><subject>Photochemotherapy</subject><subject>Psoriasis - drug therapy</subject><subject>PUVA</subject><subject>Retinoids - therapeutic use</subject><subject>Retrospective Studies</subject><subject>systemic treatment</subject><subject>topical corticosteroids</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhL6CcuCX1xHGcOXCottBSraBCfAguljeZSF7yVdvb7v57nO6qHKkvtjzvM2M_jCXAM4jrbJNBUVap4JXIcs4x4wJQZbtnbPFYeM4WHPMyRZR4wl55v-GcA8jqJTsBLBTnpViwX-eJo-BGP1Ed7B0lZjDd3lufjG0SHJnQ0xBixk_j4OnhejJdP06dGYJxyeRHZ80M2CEBKGI12Ij41-xFazpPb477Kfv-8cO35VW6-nL5aXm-SmvJc5UCQsNJojQGcyUKWaEqm7UgrFEVFW8rRdAgl0VpgIQosGmbdZ1zmDOYi1P27tB3cuPtlnzQvfU1dfF9NG69LpUsFFTiv8EoskRQc8fqEKyjF--o1ZOzvXF7DVzP_vVGz5r1rHnGUD_417uIvj3O2K57av6BR-Ex8P4QuLcd7Z_cWF9f_JhPkU8PvPWBdo-8cX_iR4WS-ufnS728XqrfX1cX-kb8BcrVov0</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Adışen, E</creator><creator>Tekin, O</creator><creator>Gülekon, A</creator><creator>Gürer, MA</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200907</creationdate><title>A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients</title><author>Adışen, E ; Tekin, O ; Gülekon, A ; Gürer, MA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5027-191d0e595aa9273458976db3e9c97480f87e1d90546a1e3349dfdbc201b3e9923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Child</topic><topic>Colchicum</topic><topic>Cyclosporine - therapeutic use</topic><topic>cyclosporine and retinoids</topic><topic>Female</topic><topic>Humans</topic><topic>Keratoderma, Palmoplantar - drug therapy</topic><topic>Male</topic><topic>methotrexate</topic><topic>Methotrexate - therapeutic use</topic><topic>Middle Aged</topic><topic>palmoplantar psoriasis</topic><topic>palmoplantar pustular psoriasis</topic><topic>Photochemotherapy</topic><topic>Psoriasis - drug therapy</topic><topic>PUVA</topic><topic>Retinoids - therapeutic use</topic><topic>Retrospective Studies</topic><topic>systemic treatment</topic><topic>topical corticosteroids</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adışen, E</creatorcontrib><creatorcontrib>Tekin, O</creatorcontrib><creatorcontrib>Gülekon, A</creatorcontrib><creatorcontrib>Gürer, MA</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adışen, E</au><au>Tekin, O</au><au>Gülekon, A</au><au>Gürer, MA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2009-07</date><risdate>2009</risdate><volume>23</volume><issue>7</issue><spage>814</spage><epage>819</epage><pages>814-819</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background Treatment options remain unsatisfactory for patients with palmoplantar psoriasis (PP) and palmoplantar pustular psoriasis (PPP).
Aim To evaluate the therapeutic responses of PP and PPP patients that were treated in our psoriasis polyclinic between 2003 and 2007.
Methods This retrospective study comprised PP (n = 62) and PPP (n = 52) patients. Treatments were individualized according to patient compliance and associating systemic diseases. The effect of systemic treatments was grouped as follows: ‘no improvement’: patients unresponsive for the present treatment; ‘partial improvement’: < 50% decrease in severity or affected area; ‘moderate improvement’: 50–75% decrease in severity or affected area, and ‘marked improvement’: > 75% decrease of the disease compared to baseline.
Results In the PP group, 17 of 62 patients showed marked improvement to topical agents, while the remaining patients required systemic agents including oral retinoids (n = 24), local psoralen plus ultraviolet A (PUVA; n = 12), methotrexate (n = 9) and cyclosporine (n = 2). Marked improvement was achieved in 53%, 45%, 47% and 100%, respectively. In these patients, two (n = 10), three (n = 5), or four (n = 5) systemic agents were used alternately.
In the PPP group, 18 of 52 patients achieved marked improvement by topical agents. Patients that required systemic agents were treated with colchicum (n = 19), local PUVA (n = 8), methotrexate (n = 4), oral retinoids (n = 3) and cyclosporine (n = 2). These treatments achieved a marked improvement in 60%, 33%, 57%, 83%, and 50% of the patients, respectively. In the course of the disease, 18 patients required two and 3 patients required three systemic agents alternately.
Conclusions Although the success rates appeared to be high, the high number of patients who required multiple systemic agents emphasized the fact that localized forms of psoriasis were resistant to therapy.
Conflicts of interest
None declared</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19470063</pmid><doi>10.1111/j.1468-3083.2009.03197.x</doi><tpages>6</tpages></addata></record> |
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subjects | Adolescent Adult Aged Child Colchicum Cyclosporine - therapeutic use cyclosporine and retinoids Female Humans Keratoderma, Palmoplantar - drug therapy Male methotrexate Methotrexate - therapeutic use Middle Aged palmoplantar psoriasis palmoplantar pustular psoriasis Photochemotherapy Psoriasis - drug therapy PUVA Retinoids - therapeutic use Retrospective Studies systemic treatment topical corticosteroids Treatment Outcome Young Adult |
title | A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients |
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