Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs

Purpose The objective was to investigate the applicability and limitations of a novel approach for measuring intrinsic dissolution rates (IDR) of very small quantities of compounds introduced as powders to buffered solutions and comparing these results to disk IDR obtained using the traditional Wood...

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Veröffentlicht in:	Pharmaceutical research 2009-09, Vol.26 (9), p.2093-2100
Hauptverfasser:	Tsinman, Konstantin, Avdeef, Alex, Tsinman, Oksana, Voloboy, Dmytro
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemical compounds Dissolution General pharmacology Measurement techniques Medical Law Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Powders Research methodology Research Paper Solubility Spectrophotometry, Ultraviolet
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