Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line

Aldosterone controls sodium balance by regulating an epithelial sodium channel (ENaC)-mediated sodium transport along the aldosterone-sensitive distal nephron, which expresses both mineralocorticoid (MR) and glucocorticoid receptors (GR). Mineralocorticoid specificity is ensured by 11beta-hydroxyste...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2005-04, Vol.16 (4), p.878-891
Hauptverfasser:	GAEGGELER, Hans-Peter, GONZALEZ-RODRIGUEZ, Elena, JAEGER, Nicole Fowler, LOFFING-CUENI, Dominique, NORREGAARD, Rikke, LOFFING, Johannes, HORISBERGER, Jean-Daniel, ROSSIER, Bernard C
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenases - metabolism Aldosterone - administration & dosage Aldosterone - pharmacology Animals Binding, Competitive Biological and medical sciences Biological Transport - drug effects Cell Line, Transformed Corticosterone - administration & dosage Corticosterone - pharmacology Dexamethasone - administration & dosage Dexamethasone - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Glucocorticoids - administration & dosage Glucocorticoids - pharmacology Kidney Tubules, Collecting - cytology Kidney Tubules, Collecting - metabolism Medical sciences Mice Nephrology. Urinary tract diseases Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - metabolism Receptors, Mineralocorticoid - agonists Receptors, Mineralocorticoid - metabolism Sodium - metabolism Vertebrates: urinary system
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