Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus
Objective Changes in metabolic homeostasis in pregnant diabetic women are potential determinants of increased adiposity of the fetus. The aim of this study was to characterize diabetes mellitus-induced changes in genes for fetoplacental energy metabolism in relation to fetal adiposity. Study Design...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2009-08, Vol.201 (2), p.209.e1-209.e10 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Radaelli, Tatiana, MD Lepercq, Jacques, MD Varastehpour, Ali, MS Basu, Subhabrata, MS Catalano, Patrick M., MD Hauguel-De Mouzon, Sylvie, PhD |
| description | Objective Changes in metabolic homeostasis in pregnant diabetic women are potential determinants of increased adiposity of the fetus. The aim of this study was to characterize diabetes mellitus-induced changes in genes for fetoplacental energy metabolism in relation to fetal adiposity. Study Design Placentas of women with type 1 diabetes mellitus, gestational diabetes mellitus (GDM), or no complications were analyzed by microarray profiling. The pattern of gene expression was assessed in primary placental cell cultures. Results Diabetes mellitus was associated with 49 alterations in gene expression at key steps in placental energy metabolism, with 67% of the alterations related to lipid pathways and 9% of the alterations related to glucose pathways. Preferential activation of lipid genes was observed in pregnancy with GDM. Type 1 diabetes mellitus induced fewer lipid modifications but an enhancement of glycosylation and acylation pathways. Oleate enhanced expression of genes for fatty acid esterification and the formation of lipid droplets 3 times as much as glucose in cultured placental cells. Conclusion These results point to fatty acids as preferential lipogenic substrates for placental cells and suggest that genes for fetoplacental lipid metabolism are enhanced selectively in GDM. The recruited genes may be instrumental in increasing transplacental lipid fluxes and the delivery of lipid substrates for fetal use. |
| doi_str_mv | 10.1016/j.ajog.2009.04.019 |
| format | Article |
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The aim of this study was to characterize diabetes mellitus-induced changes in genes for fetoplacental energy metabolism in relation to fetal adiposity. Study Design Placentas of women with type 1 diabetes mellitus, gestational diabetes mellitus (GDM), or no complications were analyzed by microarray profiling. The pattern of gene expression was assessed in primary placental cell cultures. Results Diabetes mellitus was associated with 49 alterations in gene expression at key steps in placental energy metabolism, with 67% of the alterations related to lipid pathways and 9% of the alterations related to glucose pathways. Preferential activation of lipid genes was observed in pregnancy with GDM. Type 1 diabetes mellitus induced fewer lipid modifications but an enhancement of glycosylation and acylation pathways. Oleate enhanced expression of genes for fatty acid esterification and the formation of lipid droplets 3 times as much as glucose in cultured placental cells. Conclusion These results point to fatty acids as preferential lipogenic substrates for placental cells and suggest that genes for fetoplacental lipid metabolism are enhanced selectively in GDM. The recruited genes may be instrumental in increasing transplacental lipid fluxes and the delivery of lipid substrates for fetal use.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2009.04.019</identifier><identifier>PMID: 19560108</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adipose Tissue - physiology ; Adult ; Biological and medical sciences ; Blood Glucose - genetics ; Blood Glucose - metabolism ; Cells, Cultured ; diabetes mellitus ; Diabetes Mellitus, Type 1 - genetics ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes, Gestational - genetics ; Diabetes, Gestational - metabolism ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Energy Metabolism - genetics ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; fetus ; Fetus - physiology ; Gene Expression Profiling ; Gene Expression Regulation, Developmental - physiology ; Gynecology. Andrology. Obstetrics ; Homeostasis - genetics ; human ; Humans ; Lipid Metabolism - genetics ; Medical sciences ; metabolism ; obesity ; Obesity - genetics ; Obesity - metabolism ; Obstetrics and Gynecology ; Oligonucleotide Array Sequence Analysis ; placenta ; Placenta - cytology ; Placenta - physiology ; Pregnancy</subject><ispartof>American journal of obstetrics and gynecology, 2009-08, Vol.201 (2), p.209.e1-209.e10</ispartof><rights>2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-65a69831646fe9bacc68321f55edc1efbe91d7e38fcf3c81bb5936a28c2ac1483</citedby><cites>FETCH-LOGICAL-c483t-65a69831646fe9bacc68321f55edc1efbe91d7e38fcf3c81bb5936a28c2ac1483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2009.04.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21802728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19560108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radaelli, Tatiana, MD</creatorcontrib><creatorcontrib>Lepercq, Jacques, MD</creatorcontrib><creatorcontrib>Varastehpour, Ali, MS</creatorcontrib><creatorcontrib>Basu, Subhabrata, MS</creatorcontrib><creatorcontrib>Catalano, Patrick M., MD</creatorcontrib><creatorcontrib>Hauguel-De Mouzon, Sylvie, PhD</creatorcontrib><title>Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective Changes in metabolic homeostasis in pregnant diabetic women are potential determinants of increased adiposity of the fetus. The aim of this study was to characterize diabetes mellitus-induced changes in genes for fetoplacental energy metabolism in relation to fetal adiposity. Study Design Placentas of women with type 1 diabetes mellitus, gestational diabetes mellitus (GDM), or no complications were analyzed by microarray profiling. The pattern of gene expression was assessed in primary placental cell cultures. Results Diabetes mellitus was associated with 49 alterations in gene expression at key steps in placental energy metabolism, with 67% of the alterations related to lipid pathways and 9% of the alterations related to glucose pathways. Preferential activation of lipid genes was observed in pregnancy with GDM. Type 1 diabetes mellitus induced fewer lipid modifications but an enhancement of glycosylation and acylation pathways. Oleate enhanced expression of genes for fatty acid esterification and the formation of lipid droplets 3 times as much as glucose in cultured placental cells. Conclusion These results point to fatty acids as preferential lipogenic substrates for placental cells and suggest that genes for fetoplacental lipid metabolism are enhanced selectively in GDM. The recruited genes may be instrumental in increasing transplacental lipid fluxes and the delivery of lipid substrates for fetal use.</description><subject>Adipose Tissue - physiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - genetics</subject><subject>Blood Glucose - metabolism</subject><subject>Cells, Cultured</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes, Gestational - genetics</subject><subject>Diabetes, Gestational - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Energy Metabolism - genetics</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>fetus</subject><subject>Fetus - physiology</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Homeostasis - genetics</subject><subject>human</subject><subject>Humans</subject><subject>Lipid Metabolism - genetics</subject><subject>Medical sciences</subject><subject>metabolism</subject><subject>obesity</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><subject>Obstetrics and Gynecology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>placenta</subject><subject>Placenta - cytology</subject><subject>Placenta - physiology</subject><subject>Pregnancy</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2L1TAUhoMoznX0D7iQbHTXepK2aQIiDOMnDLhQ1yFNT-7k2tvWJHUo-ONNvRcFF65C4HnfnDwJIU8ZlAyYeHkozWHalxxAlVCXwNQ9smOg2kJIIe-THQDwQlWtvCCPYjxsW674Q3LBVCOAgdyRn2-8cxhwTN4MNOB-GUzy00gnR_c4YqRuCtRhmubB2IxlavCz7-ls0u2dWSP1I51zcDSjXemdT7c5GNPvlgybsadpnZEy2nvTYcqVRxwGn5b4mDxwZoj45Lxekq_v3n65_lDcfHr_8frqprC1rFIhGiOUrJiohUPVGWuFrDhzTYO9Zeg6VKxvsZLOuspK1nWNqoTh0nJjWa64JC9OvXOYvi95OH300eYhzIjTErVom7qFGjLIT6ANU4wBnZ6DP5qwagZ6c64PenOuN-caap2d59Czc_vSHbH_GzlLzsDzM2CiNYML2ZSPfzjOJPCWb9yrE4fZxQ-PQUfrcbTY-4A26X7y_5_j9T9xO_jR5xO_4YrxMC0hP0jUTEeuQX_evsP2OUBBvnsD1S-qPLdJ</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Radaelli, Tatiana, MD</creator><creator>Lepercq, Jacques, MD</creator><creator>Varastehpour, Ali, MS</creator><creator>Basu, Subhabrata, MS</creator><creator>Catalano, Patrick M., MD</creator><creator>Hauguel-De Mouzon, Sylvie, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090801</creationdate><title>Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus</title><author>Radaelli, Tatiana, MD ; Lepercq, Jacques, MD ; Varastehpour, Ali, MS ; Basu, Subhabrata, MS ; Catalano, Patrick M., MD ; Hauguel-De Mouzon, Sylvie, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-65a69831646fe9bacc68321f55edc1efbe91d7e38fcf3c81bb5936a28c2ac1483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adipose Tissue - physiology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - genetics</topic><topic>Blood Glucose - metabolism</topic><topic>Cells, Cultured</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes, Gestational - genetics</topic><topic>Diabetes, Gestational - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Energy Metabolism - genetics</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>fetus</topic><topic>Fetus - physiology</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Homeostasis - genetics</topic><topic>human</topic><topic>Humans</topic><topic>Lipid Metabolism - genetics</topic><topic>Medical sciences</topic><topic>metabolism</topic><topic>obesity</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><topic>Obstetrics and Gynecology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>placenta</topic><topic>Placenta - cytology</topic><topic>Placenta - physiology</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radaelli, Tatiana, MD</creatorcontrib><creatorcontrib>Lepercq, Jacques, MD</creatorcontrib><creatorcontrib>Varastehpour, Ali, MS</creatorcontrib><creatorcontrib>Basu, Subhabrata, MS</creatorcontrib><creatorcontrib>Catalano, Patrick M., MD</creatorcontrib><creatorcontrib>Hauguel-De Mouzon, Sylvie, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radaelli, Tatiana, MD</au><au>Lepercq, Jacques, MD</au><au>Varastehpour, Ali, MS</au><au>Basu, Subhabrata, MS</au><au>Catalano, Patrick M., MD</au><au>Hauguel-De Mouzon, Sylvie, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>201</volume><issue>2</issue><spage>209.e1</spage><epage>209.e10</epage><pages>209.e1-209.e10</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective Changes in metabolic homeostasis in pregnant diabetic women are potential determinants of increased adiposity of the fetus. The aim of this study was to characterize diabetes mellitus-induced changes in genes for fetoplacental energy metabolism in relation to fetal adiposity. Study Design Placentas of women with type 1 diabetes mellitus, gestational diabetes mellitus (GDM), or no complications were analyzed by microarray profiling. The pattern of gene expression was assessed in primary placental cell cultures. Results Diabetes mellitus was associated with 49 alterations in gene expression at key steps in placental energy metabolism, with 67% of the alterations related to lipid pathways and 9% of the alterations related to glucose pathways. Preferential activation of lipid genes was observed in pregnancy with GDM. Type 1 diabetes mellitus induced fewer lipid modifications but an enhancement of glycosylation and acylation pathways. Oleate enhanced expression of genes for fatty acid esterification and the formation of lipid droplets 3 times as much as glucose in cultured placental cells. Conclusion These results point to fatty acids as preferential lipogenic substrates for placental cells and suggest that genes for fetoplacental lipid metabolism are enhanced selectively in GDM. The recruited genes may be instrumental in increasing transplacental lipid fluxes and the delivery of lipid substrates for fetal use.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19560108</pmid><doi>10.1016/j.ajog.2009.04.019</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - physiology Adult Biological and medical sciences Blood Glucose - genetics Blood Glucose - metabolism Cells, Cultured diabetes mellitus Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes, Gestational - genetics Diabetes, Gestational - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Metabolism - genetics Etiopathogenesis. Screening. Investigations. Target tissue resistance Female fetus Fetus - physiology Gene Expression Profiling Gene Expression Regulation, Developmental - physiology Gynecology. Andrology. Obstetrics Homeostasis - genetics human Humans Lipid Metabolism - genetics Medical sciences metabolism obesity Obesity - genetics Obesity - metabolism Obstetrics and Gynecology Oligonucleotide Array Sequence Analysis placenta Placenta - cytology Placenta - physiology Pregnancy |
| title | Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus |
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