Optical rheology of biological cells
A step stress deforming suspended cells causes a passive relaxation, due to a transiently cross-linked isotropic actin cortex underlying the cellular membrane. The fluid-to-solid transition occurs at a relaxation time coinciding with unbinding times of actin cross-linking proteins. Elastic contribut...
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| Veröffentlicht in: | Physical review letters 2005-03, Vol.94 (9), p.098103.1-098103.4, Article 098103 |
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| container_end_page | 098103.4 |
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| container_issue | 9 |
| container_start_page | 098103.1 |
| container_title | Physical review letters |
| container_volume | 94 |
| creator | WOTTAWAH, Falk SCHINKINGER, Stefan LINCOLN, Bryan ANANTHAKRISHNAN, Revathi ROMEYKE, Maren GUCK, Jochen KAS, Josef |
| description | A step stress deforming suspended cells causes a passive relaxation, due to a transiently cross-linked isotropic actin cortex underlying the cellular membrane. The fluid-to-solid transition occurs at a relaxation time coinciding with unbinding times of actin cross-linking proteins. Elastic contributions from slowly relaxing entangled filaments are negligible. The symmetric geometry of suspended cells ensures minimal statistical variability in their viscoelastic properties in contrast with adherent cells and thus is defining for different cell types. Mechanical stimuli on time scales of minutes trigger active structural responses. |
| doi_str_mv | 10.1103/PhysRevLett.94.098103 |
| format | Article |
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Biorheology ; Cell Shape ; Cytoskeleton - chemistry ; Cytoskeleton - physiology ; Elasticity ; Fibroblasts - cytology ; Fibroblasts - physiology ; Fundamental and applied biological sciences. 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The fluid-to-solid transition occurs at a relaxation time coinciding with unbinding times of actin cross-linking proteins. Elastic contributions from slowly relaxing entangled filaments are negligible. The symmetric geometry of suspended cells ensures minimal statistical variability in their viscoelastic properties in contrast with adherent cells and thus is defining for different cell types. Mechanical stimuli on time scales of minutes trigger active structural responses.</description><subject>Actins - chemistry</subject><subject>Actins - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics. Biorheology</subject><subject>Cell Shape</subject><subject>Cytoskeleton - chemistry</subject><subject>Cytoskeleton - physiology</subject><subject>Elasticity</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - physiology</subject><subject>Fundamental and applied biological sciences. 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Biorheology</topic><topic>Cell Shape</topic><topic>Cytoskeleton - chemistry</topic><topic>Cytoskeleton - physiology</topic><topic>Elasticity</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - physiology</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Physical review letters, 2005-03, Vol.94 (9), p.098103.1-098103.4, Article 098103 |
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| source | MEDLINE; American Physical Society Journals |
| subjects | Actins - chemistry Actins - physiology Animals Biological and medical sciences Biomechanical Phenomena Biomechanics. Biorheology Cell Shape Cytoskeleton - chemistry Cytoskeleton - physiology Elasticity Fibroblasts - cytology Fibroblasts - physiology Fundamental and applied biological sciences. Psychology Mice NIH 3T3 Cells Optics and Photonics Rheology - methods Tissues, organs and organisms biophysics |
| title | Optical rheology of biological cells |
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