Prognostic Implications of Positive Nonsentinel Lymph Nodes Removed During Selective Sentinel Lymphadenectomy for Breast Cancer
: Nonsentinel lymph nodes (SLNs) are commonly removed at the time of selective sentinel lymphadenectomy (SSL). Their predictive value for the rest of the nodal basin is unknown. A retrospective review of 436 breast cancer patients who underwent SSL between 12/97 and 04/03 at a single institution. O...
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| Veröffentlicht in: | The breast journal 2009-05, Vol.15 (3), p.242-246 |
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| container_title | The breast journal |
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| creator | Lang, Julie E. Liu, Liang-Chih Lu, Ying Jenkins, Tyler Hwang, Shelley E. Esserman, Laura J. Ewing, Cheryl A. Alvarado, Michael Morita, Eugene Treseler, Patrick Leong, Stanley P. |
| description | : Nonsentinel lymph nodes (SLNs) are commonly removed at the time of selective sentinel lymphadenectomy (SSL). Their predictive value for the rest of the nodal basin is unknown. A retrospective review of 436 breast cancer patients who underwent SSL between 12/97 and 04/03 at a single institution. One‐hundred nineteen patients had non‐SLNs removed at SSL; eight were positive (6.7%). Positive non‐SLNs predicted that SLNs would also be positive (p = 0.008). There was no difference in rates of additional positive nodes found on completion axillary node dissection between the non‐SLN and SLN positive patients (p = 0.62). After adjustment for covariates, the presence of positive non‐SLNs was not associated with poorer disease free survival (p = 0.24), time to systemic recurrence (p = 0.57), or overall survival (p = 0.70). Positive non‐SLNs removed during SSL are not a significant risk factor for additional positive nodes on completion axillary nodal dissection (CALND) or for worse survival than positive SLNs. |
| doi_str_mv | 10.1111/j.1524-4741.2009.00712.x |
| format | Article |
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Their predictive value for the rest of the nodal basin is unknown. A retrospective review of 436 breast cancer patients who underwent SSL between 12/97 and 04/03 at a single institution. One‐hundred nineteen patients had non‐SLNs removed at SSL; eight were positive (6.7%). Positive non‐SLNs predicted that SLNs would also be positive (p = 0.008). There was no difference in rates of additional positive nodes found on completion axillary node dissection between the non‐SLN and SLN positive patients (p = 0.62). After adjustment for covariates, the presence of positive non‐SLNs was not associated with poorer disease free survival (p = 0.24), time to systemic recurrence (p = 0.57), or overall survival (p = 0.70). Positive non‐SLNs removed during SSL are not a significant risk factor for additional positive nodes on completion axillary nodal dissection (CALND) or for worse survival than positive SLNs.</description><identifier>ISSN: 1075-122X</identifier><identifier>EISSN: 1524-4741</identifier><identifier>DOI: 10.1111/j.1524-4741.2009.00712.x</identifier><identifier>PMID: 19645778</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Female ; Humans ; Lymph Node Excision ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Middle Aged ; Neoplasm Staging ; nonsentinel lymph node ; outcomes ; Prognosis ; Retrospective Studies ; selective sentinel lymphadenectomy ; sentinel lymph node ; Sentinel Lymph Node Biopsy - methods ; SLN ; Treatment Outcome</subject><ispartof>The breast journal, 2009-05, Vol.15 (3), p.242-246</ispartof><rights>2009 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4542-21e6d918120eec17733a32b97732f61a33cc67216e9c806781fc88323880a5e33</citedby><cites>FETCH-LOGICAL-c4542-21e6d918120eec17733a32b97732f61a33cc67216e9c806781fc88323880a5e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1524-4741.2009.00712.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1524-4741.2009.00712.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19645778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lang, Julie E.</creatorcontrib><creatorcontrib>Liu, Liang-Chih</creatorcontrib><creatorcontrib>Lu, Ying</creatorcontrib><creatorcontrib>Jenkins, Tyler</creatorcontrib><creatorcontrib>Hwang, Shelley E.</creatorcontrib><creatorcontrib>Esserman, Laura J.</creatorcontrib><creatorcontrib>Ewing, Cheryl A.</creatorcontrib><creatorcontrib>Alvarado, Michael</creatorcontrib><creatorcontrib>Morita, Eugene</creatorcontrib><creatorcontrib>Treseler, Patrick</creatorcontrib><creatorcontrib>Leong, Stanley P.</creatorcontrib><title>Prognostic Implications of Positive Nonsentinel Lymph Nodes Removed During Selective Sentinel Lymphadenectomy for Breast Cancer</title><title>The breast journal</title><addtitle>Breast J</addtitle><description>: Nonsentinel lymph nodes (SLNs) are commonly removed at the time of selective sentinel lymphadenectomy (SSL). Their predictive value for the rest of the nodal basin is unknown. A retrospective review of 436 breast cancer patients who underwent SSL between 12/97 and 04/03 at a single institution. One‐hundred nineteen patients had non‐SLNs removed at SSL; eight were positive (6.7%). Positive non‐SLNs predicted that SLNs would also be positive (p = 0.008). There was no difference in rates of additional positive nodes found on completion axillary node dissection between the non‐SLN and SLN positive patients (p = 0.62). After adjustment for covariates, the presence of positive non‐SLNs was not associated with poorer disease free survival (p = 0.24), time to systemic recurrence (p = 0.57), or overall survival (p = 0.70). Positive non‐SLNs removed during SSL are not a significant risk factor for additional positive nodes on completion axillary nodal dissection (CALND) or for worse survival than positive SLNs.</description><subject>Adult</subject><subject>breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>nonsentinel lymph node</subject><subject>outcomes</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>selective sentinel lymphadenectomy</subject><subject>sentinel lymph node</subject><subject>Sentinel Lymph Node Biopsy - methods</subject><subject>SLN</subject><subject>Treatment Outcome</subject><issn>1075-122X</issn><issn>1524-4741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9P3DAQxa0KVCjtV0A-cUvqP0nsSL2U3RaoVoC6W7U3yzgT8JLEi51ddk989TrsCsQNX_w0897M6IcQpiSl8X2dpzRnWZKJjKaMkDIlRFCWrj-gw5fGXtRE5All7N8B-hTCnBDCSpJ9RAe0LLJcCHmInq69u-1c6K3BF-2isUb31nUBuxpfu2B7uwJ8GQvQ9baDBk827eIuVioI-De0bgUVHi-97W7xFBowz4HpG7euoIsN125w7Tw-9aBDj0e6M-A_o_1aNwG-7P4j9Ofnj9noPJlcnV2Mvk8Sk-UZSxiFoiqppIwAGCoE55qzmzIKVhdUc25MIRgtoDSSFELS2kjJGZeS6Bw4P0In27kL7x6WEHrV2mCgaXQHbhlUIfKs4IxFo9wajXcheKjVwttW-42iRA3w1VwNjNXAWA3w1TN8tY7R492O5U0L1WtwRzsavm0Nj7aBzbsHq9npryhiPNnGbehh_RLX_j6ez0Wu_l6eqel4PBv2qXP-H2jfosc</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Lang, Julie E.</creator><creator>Liu, Liang-Chih</creator><creator>Lu, Ying</creator><creator>Jenkins, Tyler</creator><creator>Hwang, Shelley E.</creator><creator>Esserman, Laura J.</creator><creator>Ewing, Cheryl A.</creator><creator>Alvarado, Michael</creator><creator>Morita, Eugene</creator><creator>Treseler, Patrick</creator><creator>Leong, Stanley P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200905</creationdate><title>Prognostic Implications of Positive Nonsentinel Lymph Nodes Removed During Selective Sentinel Lymphadenectomy for Breast Cancer</title><author>Lang, Julie E. ; Liu, Liang-Chih ; Lu, Ying ; Jenkins, Tyler ; Hwang, Shelley E. ; Esserman, Laura J. ; Ewing, Cheryl A. ; Alvarado, Michael ; Morita, Eugene ; Treseler, Patrick ; Leong, Stanley P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4542-21e6d918120eec17733a32b97732f61a33cc67216e9c806781fc88323880a5e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>nonsentinel lymph node</topic><topic>outcomes</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>selective sentinel lymphadenectomy</topic><topic>sentinel lymph node</topic><topic>Sentinel Lymph Node Biopsy - methods</topic><topic>SLN</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lang, Julie E.</creatorcontrib><creatorcontrib>Liu, Liang-Chih</creatorcontrib><creatorcontrib>Lu, Ying</creatorcontrib><creatorcontrib>Jenkins, Tyler</creatorcontrib><creatorcontrib>Hwang, Shelley E.</creatorcontrib><creatorcontrib>Esserman, Laura J.</creatorcontrib><creatorcontrib>Ewing, Cheryl A.</creatorcontrib><creatorcontrib>Alvarado, Michael</creatorcontrib><creatorcontrib>Morita, Eugene</creatorcontrib><creatorcontrib>Treseler, Patrick</creatorcontrib><creatorcontrib>Leong, Stanley P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The breast journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lang, Julie E.</au><au>Liu, Liang-Chih</au><au>Lu, Ying</au><au>Jenkins, Tyler</au><au>Hwang, Shelley E.</au><au>Esserman, Laura J.</au><au>Ewing, Cheryl A.</au><au>Alvarado, Michael</au><au>Morita, Eugene</au><au>Treseler, Patrick</au><au>Leong, Stanley P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Implications of Positive Nonsentinel Lymph Nodes Removed During Selective Sentinel Lymphadenectomy for Breast Cancer</atitle><jtitle>The breast journal</jtitle><addtitle>Breast J</addtitle><date>2009-05</date><risdate>2009</risdate><volume>15</volume><issue>3</issue><spage>242</spage><epage>246</epage><pages>242-246</pages><issn>1075-122X</issn><eissn>1524-4741</eissn><abstract>: Nonsentinel lymph nodes (SLNs) are commonly removed at the time of selective sentinel lymphadenectomy (SSL). Their predictive value for the rest of the nodal basin is unknown. A retrospective review of 436 breast cancer patients who underwent SSL between 12/97 and 04/03 at a single institution. One‐hundred nineteen patients had non‐SLNs removed at SSL; eight were positive (6.7%). Positive non‐SLNs predicted that SLNs would also be positive (p = 0.008). There was no difference in rates of additional positive nodes found on completion axillary node dissection between the non‐SLN and SLN positive patients (p = 0.62). After adjustment for covariates, the presence of positive non‐SLNs was not associated with poorer disease free survival (p = 0.24), time to systemic recurrence (p = 0.57), or overall survival (p = 0.70). Positive non‐SLNs removed during SSL are not a significant risk factor for additional positive nodes on completion axillary nodal dissection (CALND) or for worse survival than positive SLNs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19645778</pmid><doi>10.1111/j.1524-4741.2009.00712.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - pathology Breast Neoplasms - surgery Female Humans Lymph Node Excision Lymph Nodes - pathology Lymph Nodes - surgery Middle Aged Neoplasm Staging nonsentinel lymph node outcomes Prognosis Retrospective Studies selective sentinel lymphadenectomy sentinel lymph node Sentinel Lymph Node Biopsy - methods SLN Treatment Outcome |
| title | Prognostic Implications of Positive Nonsentinel Lymph Nodes Removed During Selective Sentinel Lymphadenectomy for Breast Cancer |
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