Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery

Natural product analogs are significant sources for therapeutic agents. To capitalize efficiently on the effective features of naturally occurring substances, a natural product-based library production platform has been devised at Aurigene for drug lead discovery. This approach combines the attracti...

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Veröffentlicht in:	Molecular diversity 2005, Vol.9 (1-3), p.131-139
Hauptverfasser:	Samiulla, D S, Vaidyanathan, V V, Arun, P C, Balan, G, Blaze, M, Bondre, S, Chandrasekhar, G, Gadakh, A, Kumar, R, Kharvi, G, Kim, H O, Kumar, S, Malikayil, J A, Moger, M, Mone, M K, Nagarjuna, P, Ogbu, C, Pendhalkar, D, Rao, A V S Raja, Rao, G Venkateshwar, Sarma, V K, Shaik, S, Sharma, G V R, Singh, S, Sreedhar, C, Sonawane, R, Timmanna, U, Hardy, L W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Biological Factors - chemistry Cytochrome P-450 Enzyme Inhibitors Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Indicators and Reagents Microsomes, Liver - drug effects Microsomes, Liver - metabolism Models, Molecular Natural products Pharmaceutical Preparations - chemical synthesis Plant Extracts - chemistry Solubility
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