Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations
Eating disorders (ED), such as anorexia nervosa (AN) and bulimia nervosa (BN), are complex psychiatric disorders where different genetic and environmental factors are involved. Several lines of evidence support that brain-derived neurotrophic factor (BDNF) plays an essential role in eating behaviour...
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| Veröffentlicht in: | European journal of human genetics : EJHG 2005-04, Vol.13 (4), p.428-434 |
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| creator | Ribasés, Marta Gratacòs, Mònica Fernández-Aranda, Fernando Bellodi, Laura Boni, Claudette Anderluh, Marija Cristina Cavallini, Maria Cellini, Elena Di Bella, Daniela Erzegovesi, Stefano Foulon, Christine Gabrovsek, Mojca Gorwood, Philip Hebebrand, Johannes Hinney, Anke Holliday, Jo Hu, Xun Karwautz, Andreas Kipman, Amélie Komel, Radovan Nacmias, Benedetta Remschmidt, Helmut Ricca, Valdo Sorbi, Sandro Tomori, Martina Wagner, Gudrun Treasure, Janet Collier, David A Estivill, Xavier |
| description | Eating disorders (ED), such as anorexia nervosa (AN) and bulimia nervosa (BN), are complex psychiatric disorders where different genetic and environmental factors are involved. Several lines of evidence support that brain-derived neurotrophic factor (BDNF) plays an essential role in eating behaviour and that alterations on this neurotrophic system participates in the susceptibility to both AN and BN. Accordingly, intraventricular administration of BDNF in rats determines food starvation and body weight loss, while
BDNF
or its specific receptor
NTRK2
knockout mice develop obesity and hyperphagia. Case–control studies also suggest a
BDNF
contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the
BDNF
gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and −270C/T
BDNF
SNPs and ED in six different European populations. To replicate these results, avoiding population stratification effects, we recruited 453 ED trios from eight European centres and performed a family-based association study. Both haplotype relative risk (HRR) and haplotype-based haplotype relative risk (HHRR) methods showed a positive association between the Met66 allele and ANR. Consistently, we also observed an effect of the Met66 variant on low minBMI and a preferential transmission of the −270C/Met66 haplotype to the affected ANR offspring. These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI. |
| doi_str_mv | 10.1038/sj.ejhg.5201351 |
| format | Article |
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BDNF
or its specific receptor
NTRK2
knockout mice develop obesity and hyperphagia. Case–control studies also suggest a
BDNF
contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the
BDNF
gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and −270C/T
BDNF
SNPs and ED in six different European populations. To replicate these results, avoiding population stratification effects, we recruited 453 ED trios from eight European centres and performed a family-based association study. Both haplotype relative risk (HRR) and haplotype-based haplotype relative risk (HHRR) methods showed a positive association between the Met66 allele and ANR. Consistently, we also observed an effect of the Met66 variant on low minBMI and a preferential transmission of the −270C/Met66 haplotype to the affected ANR offspring. These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI.</description><identifier>ISSN: 1018-4813</identifier><identifier>EISSN: 1476-5438</identifier><identifier>DOI: 10.1038/sj.ejhg.5201351</identifier><identifier>PMID: 15657604</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Alleles ; Anorexia ; Anorexia nervosa ; Anorexia Nervosa - epidemiology ; Anorexia Nervosa - genetics ; Bioinformatics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedical research ; Biomedicine ; Body Mass Index ; Body weight ; Body weight loss ; Brain research ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Bulimia ; Bulimia - epidemiology ; Bulimia - genetics ; Bulimia nervosa ; Child & adolescent psychiatry ; Cytogenetics ; Eating disorders ; Environmental factors ; Europe - epidemiology ; Family ; Female ; Gene Expression ; General aspects. Genetic counseling ; Genetic Linkage ; Genetic Predisposition to Disease ; Genetics ; Genotype ; Haplotypes ; Haplotypes - genetics ; Human Genetics ; Humans ; Hyperphagia ; Male ; Medical genetics ; Medical sciences ; Mental disorders ; Obesity ; Population studies ; Progeny ; Single-nucleotide polymorphism ; Starvation ; Studies ; Survival analysis</subject><ispartof>European journal of human genetics : EJHG, 2005-04, Vol.13 (4), p.428-434</ispartof><rights>Springer Nature Switzerland AG 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Apr 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-b19ec0c82f5e645ca769e13768fadcb0cb0dc3cab2ef97ce6811ca7713bdf3213</citedby><cites>FETCH-LOGICAL-c434t-b19ec0c82f5e645ca769e13768fadcb0cb0dc3cab2ef97ce6811ca7713bdf3213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ejhg.5201351$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ejhg.5201351$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16667859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15657604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribasés, Marta</creatorcontrib><creatorcontrib>Gratacòs, Mònica</creatorcontrib><creatorcontrib>Fernández-Aranda, Fernando</creatorcontrib><creatorcontrib>Bellodi, Laura</creatorcontrib><creatorcontrib>Boni, Claudette</creatorcontrib><creatorcontrib>Anderluh, Marija</creatorcontrib><creatorcontrib>Cristina Cavallini, Maria</creatorcontrib><creatorcontrib>Cellini, Elena</creatorcontrib><creatorcontrib>Di Bella, Daniela</creatorcontrib><creatorcontrib>Erzegovesi, Stefano</creatorcontrib><creatorcontrib>Foulon, Christine</creatorcontrib><creatorcontrib>Gabrovsek, Mojca</creatorcontrib><creatorcontrib>Gorwood, Philip</creatorcontrib><creatorcontrib>Hebebrand, Johannes</creatorcontrib><creatorcontrib>Hinney, Anke</creatorcontrib><creatorcontrib>Holliday, Jo</creatorcontrib><creatorcontrib>Hu, Xun</creatorcontrib><creatorcontrib>Karwautz, Andreas</creatorcontrib><creatorcontrib>Kipman, Amélie</creatorcontrib><creatorcontrib>Komel, Radovan</creatorcontrib><creatorcontrib>Nacmias, Benedetta</creatorcontrib><creatorcontrib>Remschmidt, Helmut</creatorcontrib><creatorcontrib>Ricca, Valdo</creatorcontrib><creatorcontrib>Sorbi, Sandro</creatorcontrib><creatorcontrib>Tomori, Martina</creatorcontrib><creatorcontrib>Wagner, Gudrun</creatorcontrib><creatorcontrib>Treasure, Janet</creatorcontrib><creatorcontrib>Collier, David A</creatorcontrib><creatorcontrib>Estivill, Xavier</creatorcontrib><title>Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations</title><title>European journal of human genetics : EJHG</title><addtitle>Eur J Hum Genet</addtitle><addtitle>Eur J Hum Genet</addtitle><description>Eating disorders (ED), such as anorexia nervosa (AN) and bulimia nervosa (BN), are complex psychiatric disorders where different genetic and environmental factors are involved. Several lines of evidence support that brain-derived neurotrophic factor (BDNF) plays an essential role in eating behaviour and that alterations on this neurotrophic system participates in the susceptibility to both AN and BN. Accordingly, intraventricular administration of BDNF in rats determines food starvation and body weight loss, while
BDNF
or its specific receptor
NTRK2
knockout mice develop obesity and hyperphagia. Case–control studies also suggest a
BDNF
contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the
BDNF
gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and −270C/T
BDNF
SNPs and ED in six different European populations. To replicate these results, avoiding population stratification effects, we recruited 453 ED trios from eight European centres and performed a family-based association study. Both haplotype relative risk (HRR) and haplotype-based haplotype relative risk (HHRR) methods showed a positive association between the Met66 allele and ANR. Consistently, we also observed an effect of the Met66 variant on low minBMI and a preferential transmission of the −270C/Met66 haplotype to the affected ANR offspring. These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI.</description><subject>Adult</subject><subject>Alleles</subject><subject>Anorexia</subject><subject>Anorexia nervosa</subject><subject>Anorexia Nervosa - epidemiology</subject><subject>Anorexia Nervosa - genetics</subject><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical research</subject><subject>Biomedicine</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Brain research</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Bulimia</subject><subject>Bulimia - epidemiology</subject><subject>Bulimia - genetics</subject><subject>Bulimia nervosa</subject><subject>Child & adolescent psychiatry</subject><subject>Cytogenetics</subject><subject>Eating disorders</subject><subject>Environmental factors</subject><subject>Europe - epidemiology</subject><subject>Family</subject><subject>Female</subject><subject>Gene Expression</subject><subject>General aspects. Genetic counseling</subject><subject>Genetic Linkage</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hyperphagia</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>Obesity</subject><subject>Population studies</subject><subject>Progeny</subject><subject>Single-nucleotide polymorphism</subject><subject>Starvation</subject><subject>Studies</subject><subject>Survival analysis</subject><issn>1018-4813</issn><issn>1476-5438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp10VGL1DAQAOAgineePvsmQdC37iVNk7S-needCoe-6HNJ0-luSpvUTHve_gz_sVm3sCIIgYTMl5kJQ8hLzjacifIS-w30u-1G5owLyR-Rc15olclClI_TmfEyK0ouzsgzxJ6xFNT8KTnjUkmtWHFOfl0hBuvM7IKnoaPvP3y5pT_dvKMRcI7Ozs5vqfEhwoMz1EO8D2jSRUtH5924jLQJ7Z6OBpE638LDO2poZ0Y37LPGILTU_FUB5yXhVAfcdjfTmyWGCYynU5iW4Q_B5-RJZwaEF-t-Qb7f3ny7_pTdff34-frqLrOFKOas4RVYZsu8k6AKaY1WFXChVdmZ1jYsrdYKa5ocukpbUCXnCWkumrYTORcX5O0x7xTDjyV9th4dWhgG4yEsWCstCylUkeDrf2AfluhTb3XOdSlUJQ7o8ohsDIgRunqKbjRxX3NWH0ZVY18fRlWvo0ovXq1pl2aE9uTX2STwZgUGrRm6aLx1eHJKKV3KKjl2dJhCfgvx1N__av8G7Jew3A</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Ribasés, Marta</creator><creator>Gratacòs, Mònica</creator><creator>Fernández-Aranda, Fernando</creator><creator>Bellodi, Laura</creator><creator>Boni, Claudette</creator><creator>Anderluh, Marija</creator><creator>Cristina Cavallini, Maria</creator><creator>Cellini, Elena</creator><creator>Di Bella, Daniela</creator><creator>Erzegovesi, Stefano</creator><creator>Foulon, Christine</creator><creator>Gabrovsek, Mojca</creator><creator>Gorwood, Philip</creator><creator>Hebebrand, Johannes</creator><creator>Hinney, Anke</creator><creator>Holliday, Jo</creator><creator>Hu, Xun</creator><creator>Karwautz, Andreas</creator><creator>Kipman, Amélie</creator><creator>Komel, Radovan</creator><creator>Nacmias, Benedetta</creator><creator>Remschmidt, Helmut</creator><creator>Ricca, Valdo</creator><creator>Sorbi, Sandro</creator><creator>Tomori, Martina</creator><creator>Wagner, Gudrun</creator><creator>Treasure, Janet</creator><creator>Collier, David A</creator><creator>Estivill, Xavier</creator><general>Springer International Publishing</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations</title><author>Ribasés, Marta ; Gratacòs, Mònica ; Fernández-Aranda, Fernando ; Bellodi, Laura ; Boni, Claudette ; Anderluh, Marija ; Cristina Cavallini, Maria ; Cellini, Elena ; Di Bella, Daniela ; Erzegovesi, Stefano ; Foulon, Christine ; Gabrovsek, Mojca ; Gorwood, Philip ; Hebebrand, Johannes ; Hinney, Anke ; Holliday, Jo ; Hu, Xun ; Karwautz, Andreas ; Kipman, Amélie ; Komel, Radovan ; Nacmias, Benedetta ; Remschmidt, Helmut ; Ricca, Valdo ; Sorbi, Sandro ; Tomori, Martina ; Wagner, Gudrun ; Treasure, Janet ; Collier, David A ; Estivill, Xavier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-b19ec0c82f5e645ca769e13768fadcb0cb0dc3cab2ef97ce6811ca7713bdf3213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Anorexia</topic><topic>Anorexia nervosa</topic><topic>Anorexia Nervosa - epidemiology</topic><topic>Anorexia Nervosa - genetics</topic><topic>Bioinformatics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical research</topic><topic>Biomedicine</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Brain research</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Bulimia</topic><topic>Bulimia - epidemiology</topic><topic>Bulimia - genetics</topic><topic>Bulimia nervosa</topic><topic>Child & adolescent psychiatry</topic><topic>Cytogenetics</topic><topic>Eating disorders</topic><topic>Environmental factors</topic><topic>Europe - epidemiology</topic><topic>Family</topic><topic>Female</topic><topic>Gene Expression</topic><topic>General aspects. 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Academic</collection><jtitle>European journal of human genetics : EJHG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribasés, Marta</au><au>Gratacòs, Mònica</au><au>Fernández-Aranda, Fernando</au><au>Bellodi, Laura</au><au>Boni, Claudette</au><au>Anderluh, Marija</au><au>Cristina Cavallini, Maria</au><au>Cellini, Elena</au><au>Di Bella, Daniela</au><au>Erzegovesi, Stefano</au><au>Foulon, Christine</au><au>Gabrovsek, Mojca</au><au>Gorwood, Philip</au><au>Hebebrand, Johannes</au><au>Hinney, Anke</au><au>Holliday, Jo</au><au>Hu, Xun</au><au>Karwautz, Andreas</au><au>Kipman, Amélie</au><au>Komel, Radovan</au><au>Nacmias, Benedetta</au><au>Remschmidt, Helmut</au><au>Ricca, Valdo</au><au>Sorbi, Sandro</au><au>Tomori, Martina</au><au>Wagner, Gudrun</au><au>Treasure, Janet</au><au>Collier, David A</au><au>Estivill, Xavier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations</atitle><jtitle>European journal of human genetics : EJHG</jtitle><stitle>Eur J Hum Genet</stitle><addtitle>Eur J Hum Genet</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>13</volume><issue>4</issue><spage>428</spage><epage>434</epage><pages>428-434</pages><issn>1018-4813</issn><eissn>1476-5438</eissn><abstract>Eating disorders (ED), such as anorexia nervosa (AN) and bulimia nervosa (BN), are complex psychiatric disorders where different genetic and environmental factors are involved. Several lines of evidence support that brain-derived neurotrophic factor (BDNF) plays an essential role in eating behaviour and that alterations on this neurotrophic system participates in the susceptibility to both AN and BN. Accordingly, intraventricular administration of BDNF in rats determines food starvation and body weight loss, while
BDNF
or its specific receptor
NTRK2
knockout mice develop obesity and hyperphagia. Case–control studies also suggest a
BDNF
contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the
BDNF
gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and −270C/T
BDNF
SNPs and ED in six different European populations. To replicate these results, avoiding population stratification effects, we recruited 453 ED trios from eight European centres and performed a family-based association study. Both haplotype relative risk (HRR) and haplotype-based haplotype relative risk (HHRR) methods showed a positive association between the Met66 allele and ANR. Consistently, we also observed an effect of the Met66 variant on low minBMI and a preferential transmission of the −270C/Met66 haplotype to the affected ANR offspring. These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>15657604</pmid><doi>10.1038/sj.ejhg.5201351</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1018-4813 |
| ispartof | European journal of human genetics : EJHG, 2005-04, Vol.13 (4), p.428-434 |
| issn | 1018-4813 1476-5438 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67545364 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | Adult Alleles Anorexia Anorexia nervosa Anorexia Nervosa - epidemiology Anorexia Nervosa - genetics Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical research Biomedicine Body Mass Index Body weight Body weight loss Brain research Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Bulimia Bulimia - epidemiology Bulimia - genetics Bulimia nervosa Child & adolescent psychiatry Cytogenetics Eating disorders Environmental factors Europe - epidemiology Family Female Gene Expression General aspects. Genetic counseling Genetic Linkage Genetic Predisposition to Disease Genetics Genotype Haplotypes Haplotypes - genetics Human Genetics Humans Hyperphagia Male Medical genetics Medical sciences Mental disorders Obesity Population studies Progeny Single-nucleotide polymorphism Starvation Studies Survival analysis |
| title | Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T15%3A07%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20BDNF%20with%20restricting%20anorexia%20nervosa%20and%20minimum%20body%20mass%20index:%20a%20family-based%20association%20study%20of%20eight%20European%20populations&rft.jtitle=European%20journal%20of%20human%20genetics%20:%20EJHG&rft.au=Ribas%C3%A9s,%20Marta&rft.date=2005-04-01&rft.volume=13&rft.issue=4&rft.spage=428&rft.epage=434&rft.pages=428-434&rft.issn=1018-4813&rft.eissn=1476-5438&rft_id=info:doi/10.1038/sj.ejhg.5201351&rft_dat=%3Cproquest_cross%3E971688161%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217836934&rft_id=info:pmid/15657604&rfr_iscdi=true |