Force barriers for membrane tube formation
We used optical tweezers to measure the force-extension curve for the formation of tubes from giant vesicles. We show that a significant force barrier exists for the formation of tubes, which increases linearly with the radius of the area on which the pulling force is exerted. The tubes form through...
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| Veröffentlicht in: | Physical review letters 2005-02, Vol.94 (6), p.068101.1-068101.4, Article 068101 |
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| container_end_page | 068101.4 |
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| container_issue | 6 |
| container_start_page | 068101.1 |
| container_title | Physical review letters |
| container_volume | 94 |
| creator | KOSTER, Gerbrand CACCIUTO, Angelo DERENYI, Imre FRENKEL, Daan DOGTEROM, Marileen |
| description | We used optical tweezers to measure the force-extension curve for the formation of tubes from giant vesicles. We show that a significant force barrier exists for the formation of tubes, which increases linearly with the radius of the area on which the pulling force is exerted. The tubes form through a first-order transition with accompanying hysteresis. We confirm these results with Monte Carlo simulations and theoretical calculations. Whether membrane tubes can be formed in, for example, biological cells, thus depends on the details of how forces are applied. |
| doi_str_mv | 10.1103/PhysRevLett.94.068101 |
| format | Article |
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We show that a significant force barrier exists for the formation of tubes, which increases linearly with the radius of the area on which the pulling force is exerted. The tubes form through a first-order transition with accompanying hysteresis. We confirm these results with Monte Carlo simulations and theoretical calculations. Whether membrane tubes can be formed in, for example, biological cells, thus depends on the details of how forces are applied.</description><identifier>ISSN: 0031-9007</identifier><identifier>EISSN: 1079-7114</identifier><identifier>DOI: 10.1103/PhysRevLett.94.068101</identifier><identifier>PMID: 15783778</identifier><identifier>CODEN: PRLTAO</identifier><language>eng</language><publisher>Ridge, NY: American Physical Society</publisher><subject>Biological and medical sciences ; Biotin - chemistry ; Cell membranes. Ionic channels. Membrane pores ; Cell structures and functions ; Computer Simulation ; Fundamental and applied biological sciences. Psychology ; Liposomes - chemistry ; Membranes - chemistry ; Membranes, bilayers, and vesicles ; Molecular and cellular biology ; Monte Carlo Method ; Phosphatidylcholines - chemistry ; Phosphatidylethanolamines - chemistry ; Polystyrenes - chemistry ; Streptavidin - chemistry ; Thermodynamics</subject><ispartof>Physical review letters, 2005-02, Vol.94 (6), p.068101.1-068101.4, Article 068101</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-63f8750c25ec830fc7976c273c8597747663a16fb84d936a23135ba4d1febff93</citedby><cites>FETCH-LOGICAL-c384t-63f8750c25ec830fc7976c273c8597747663a16fb84d936a23135ba4d1febff93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,2865,2866,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16600113$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15783778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOSTER, Gerbrand</creatorcontrib><creatorcontrib>CACCIUTO, Angelo</creatorcontrib><creatorcontrib>DERENYI, Imre</creatorcontrib><creatorcontrib>FRENKEL, Daan</creatorcontrib><creatorcontrib>DOGTEROM, Marileen</creatorcontrib><title>Force barriers for membrane tube formation</title><title>Physical review letters</title><addtitle>Phys Rev Lett</addtitle><description>We used optical tweezers to measure the force-extension curve for the formation of tubes from giant vesicles. We show that a significant force barrier exists for the formation of tubes, which increases linearly with the radius of the area on which the pulling force is exerted. The tubes form through a first-order transition with accompanying hysteresis. We confirm these results with Monte Carlo simulations and theoretical calculations. Whether membrane tubes can be formed in, for example, biological cells, thus depends on the details of how forces are applied.</description><subject>Biological and medical sciences</subject><subject>Biotin - chemistry</subject><subject>Cell membranes. Ionic channels. Membrane pores</subject><subject>Cell structures and functions</subject><subject>Computer Simulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Liposomes - chemistry</subject><subject>Membranes - chemistry</subject><subject>Membranes, bilayers, and vesicles</subject><subject>Molecular and cellular biology</subject><subject>Monte Carlo Method</subject><subject>Phosphatidylcholines - chemistry</subject><subject>Phosphatidylethanolamines - chemistry</subject><subject>Polystyrenes - chemistry</subject><subject>Streptavidin - chemistry</subject><subject>Thermodynamics</subject><issn>0031-9007</issn><issn>1079-7114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1LwzAUhoMobk5_gtIbvRA6z2nSfFzKcCoMFNHrkGQJVtp1Jq2wf2_HCnp14PC87zk8hFwizBGB3r1-7tKb_1n5rpsrNgcuEfCITBGEygUiOyZTAIq5AhATcpbSFwBgweUpmWApJBVCTsntso3OZ9bEWPmYstDGrPGNjWbjs663fr9pTFe1m3NyEkyd_MU4Z-Rj-fC-eMpXL4_Pi_tV7qhkXc5pkKIEV5TeSQrBCSW4KwR1slRCMME5NciDlWytKDcFRVpaw9YYvA1B0Rm5OfRuY_vd-9TppkrO1_XwUtsnzUXJGOc4gOUBdLFNKfqgt7FqTNxpBL2XpP9J0orpg6QhdzUe6G3j13-p0coAXI-ASc7UYZDhqvTHcT6YREp_ASd8cU8</recordid><startdate>20050218</startdate><enddate>20050218</enddate><creator>KOSTER, Gerbrand</creator><creator>CACCIUTO, Angelo</creator><creator>DERENYI, Imre</creator><creator>FRENKEL, Daan</creator><creator>DOGTEROM, Marileen</creator><general>American Physical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050218</creationdate><title>Force barriers for membrane tube formation</title><author>KOSTER, Gerbrand ; CACCIUTO, Angelo ; DERENYI, Imre ; FRENKEL, Daan ; DOGTEROM, Marileen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-63f8750c25ec830fc7976c273c8597747663a16fb84d936a23135ba4d1febff93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Biotin - chemistry</topic><topic>Cell membranes. Ionic channels. Membrane pores</topic><topic>Cell structures and functions</topic><topic>Computer Simulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Liposomes - chemistry</topic><topic>Membranes - chemistry</topic><topic>Membranes, bilayers, and vesicles</topic><topic>Molecular and cellular biology</topic><topic>Monte Carlo Method</topic><topic>Phosphatidylcholines - chemistry</topic><topic>Phosphatidylethanolamines - chemistry</topic><topic>Polystyrenes - chemistry</topic><topic>Streptavidin - chemistry</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOSTER, Gerbrand</creatorcontrib><creatorcontrib>CACCIUTO, Angelo</creatorcontrib><creatorcontrib>DERENYI, Imre</creatorcontrib><creatorcontrib>FRENKEL, Daan</creatorcontrib><creatorcontrib>DOGTEROM, Marileen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physical review letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOSTER, Gerbrand</au><au>CACCIUTO, Angelo</au><au>DERENYI, Imre</au><au>FRENKEL, Daan</au><au>DOGTEROM, Marileen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Force barriers for membrane tube formation</atitle><jtitle>Physical review letters</jtitle><addtitle>Phys Rev Lett</addtitle><date>2005-02-18</date><risdate>2005</risdate><volume>94</volume><issue>6</issue><spage>068101.1</spage><epage>068101.4</epage><pages>068101.1-068101.4</pages><artnum>068101</artnum><issn>0031-9007</issn><eissn>1079-7114</eissn><coden>PRLTAO</coden><abstract>We used optical tweezers to measure the force-extension curve for the formation of tubes from giant vesicles. We show that a significant force barrier exists for the formation of tubes, which increases linearly with the radius of the area on which the pulling force is exerted. The tubes form through a first-order transition with accompanying hysteresis. We confirm these results with Monte Carlo simulations and theoretical calculations. Whether membrane tubes can be formed in, for example, biological cells, thus depends on the details of how forces are applied.</abstract><cop>Ridge, NY</cop><pub>American Physical Society</pub><pmid>15783778</pmid><doi>10.1103/PhysRevLett.94.068101</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Physical review letters, 2005-02, Vol.94 (6), p.068101.1-068101.4, Article 068101 |
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| source | MEDLINE; American Physical Society Journals |
| subjects | Biological and medical sciences Biotin - chemistry Cell membranes. Ionic channels. Membrane pores Cell structures and functions Computer Simulation Fundamental and applied biological sciences. Psychology Liposomes - chemistry Membranes - chemistry Membranes, bilayers, and vesicles Molecular and cellular biology Monte Carlo Method Phosphatidylcholines - chemistry Phosphatidylethanolamines - chemistry Polystyrenes - chemistry Streptavidin - chemistry Thermodynamics |
| title | Force barriers for membrane tube formation |
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