Human Papillomavirus Genotype Specificity of Hybrid Capture 2 Low-Risk Probe Cocktail
A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive re...
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| Veröffentlicht in: | Journal of Clinical Microbiology 2009-08, Vol.47 (8), p.2611-2615 |
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| container_end_page | 2615 |
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| container_issue | 8 |
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| container_title | Journal of Clinical Microbiology |
| container_volume | 47 |
| creator | Poljak, Mario Kocjan, Boštjan J Kovanda, Anja Lunar, Maja M Lepej, Snježana Židovec Planinić, Ana Seme, Katja Vince, Adriana |
| description | A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gray zone is recommended. |
| doi_str_mv | 10.1128/JCM.00278-09 |
| format | Article |
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Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gray zone is recommended.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/JCM.00278-09</identifier><identifier>PMID: 19494080</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cross Reactions ; DNA, Viral - genetics ; DNA, Viral - isolation & purification ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Humans ; Microbiology ; Miscellaneous ; Nucleic Acid Hybridization - methods ; Oligonucleotide Probes - genetics ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - diagnosis ; Sensitivity and Specificity ; Virology ; Young Adult</subject><ispartof>Journal of Clinical Microbiology, 2009-08, Vol.47 (8), p.2611-2615</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-2d3c4f271398fcab6c434fe0ce01f7967317c1bd28f77b0c1f0e32cbb29fd11c3</citedby><cites>FETCH-LOGICAL-c462t-2d3c4f271398fcab6c434fe0ce01f7967317c1bd28f77b0c1f0e32cbb29fd11c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725686/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725686/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,3189,3190,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21815670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19494080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poljak, Mario</creatorcontrib><creatorcontrib>Kocjan, Boštjan J</creatorcontrib><creatorcontrib>Kovanda, Anja</creatorcontrib><creatorcontrib>Lunar, Maja M</creatorcontrib><creatorcontrib>Lepej, Snježana Židovec</creatorcontrib><creatorcontrib>Planinić, Ana</creatorcontrib><creatorcontrib>Seme, Katja</creatorcontrib><creatorcontrib>Vince, Adriana</creatorcontrib><title>Human Papillomavirus Genotype Specificity of Hybrid Capture 2 Low-Risk Probe Cocktail</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gray zone is recommended.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cross Reactions</subject><subject>DNA, Viral - genetics</subject><subject>DNA, Viral - isolation & purification</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Nucleic Acid Hybridization - methods</subject><subject>Oligonucleotide Probes - genetics</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Sensitivity and Specificity</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0095-1137</issn><issn>1098-660X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0cFv0zAUBnALgVhXuHGGcBgnMvxsx44vSCiCFVTExKjEzXIcu_WWxMFONvW_J6PVgJMP76fvPflD6AXgcwBSvvtSfT3HmIgyx_IRWgCWZc45_vkYLTCWRQ5AxQk6TekaY2CsKJ6iE5BMMlziBdqspk732aUefNuGTt_6OKXswvZh3A82uxqs8c4bP-6z4LLVvo6-ySo9jFO0GcnW4S7_7tNNdhlDbbMqmJtR-_YZeuJ0m-zz47tEm08ff1SrfP3t4nP1YZ0bxsmYk4Ya5ogAKktndM0No8xZbCwGJyQXFISBuiGlE6LGBhy2lJi6JtI1AIYu0ftD7jDVnW2M7ceoWzVE3-m4V0F79f-k9zu1DbeKCFLwks8Bb44BMfyabBpV55Oxbat7G6akuCgYpZLM8O0BmhhSitY9LAGs7ntQcw_qTw8Ky5m__Pewv_j48TM4OwKdjG5d1L3x6cERKKHg4t69Prid3-7ufLRKp05dm04xoUpF-FzvEr06GKeD0ts452yuCAaKgXMgrKC_ARcPpaU</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Poljak, Mario</creator><creator>Kocjan, Boštjan J</creator><creator>Kovanda, Anja</creator><creator>Lunar, Maja M</creator><creator>Lepej, Snježana Židovec</creator><creator>Planinić, Ana</creator><creator>Seme, Katja</creator><creator>Vince, Adriana</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090801</creationdate><title>Human Papillomavirus Genotype Specificity of Hybrid Capture 2 Low-Risk Probe Cocktail</title><author>Poljak, Mario ; Kocjan, Boštjan J ; Kovanda, Anja ; Lunar, Maja M ; Lepej, Snježana Židovec ; Planinić, Ana ; Seme, Katja ; Vince, Adriana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-2d3c4f271398fcab6c434fe0ce01f7967317c1bd28f77b0c1f0e32cbb29fd11c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cross Reactions</topic><topic>DNA, Viral - genetics</topic><topic>DNA, Viral - isolation & purification</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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| subjects | Adolescent Adult Biological and medical sciences Cross Reactions DNA, Viral - genetics DNA, Viral - isolation & purification Female Fundamental and applied biological sciences. Psychology Genotype Humans Microbiology Miscellaneous Nucleic Acid Hybridization - methods Oligonucleotide Probes - genetics Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - diagnosis Sensitivity and Specificity Virology Young Adult |
| title | Human Papillomavirus Genotype Specificity of Hybrid Capture 2 Low-Risk Probe Cocktail |
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