Human Papillomavirus Genotype Specificity of Hybrid Capture 2 Low-Risk Probe Cocktail

A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive re...

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Veröffentlicht in:Journal of Clinical Microbiology 2009-08, Vol.47 (8), p.2611-2615
Hauptverfasser: Poljak, Mario, Kocjan, Boštjan J, Kovanda, Anja, Lunar, Maja M, Lepej, Snježana Židovec, Planinić, Ana, Seme, Katja, Vince, Adriana
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Sprache:eng
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Zusammenfassung:A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gray zone is recommended.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00278-09