Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging
Abstract Adult neurogenesis exists in most mammalian species, including humans, in two main areas: the subventricular zone (new cells migrate to the olfactory bulbs) and the dentate gyrus of the hippocampus. Many factors affect neurogenesis in the hippocampus and the subventricular zone, however the...
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| Veröffentlicht in: | Frontiers in neuroendocrinology 2009-08, Vol.30 (3), p.343-357 |
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| creator | Pawluski, Jodi L Brummelte, Susanne Barha, Cindy K Crozier, Tamara M Galea, Liisa A.M |
| description | Abstract Adult neurogenesis exists in most mammalian species, including humans, in two main areas: the subventricular zone (new cells migrate to the olfactory bulbs) and the dentate gyrus of the hippocampus. Many factors affect neurogenesis in the hippocampus and the subventricular zone, however the focus of this review will be on factors that affect hippocampal neurogenesis, particularly in females. Sex differences are often seen in levels of hippocampal neurogenesis, and these effects are due in part to differences in circulating levels of steroid hormones such as estradiol, progesterone, and corticosterone during the estrous cycle, in response to stress, with reproduction (including pregnancy and lactation), and aging. Depletion and administration of these same steroid hormones also has marked effects on hippocampal neurogenesis in the adult female, and these effects are dependent upon reproductive status and age. The present review will focus on current research investigating how hippocampal neurogenesis is altered in the adult female rodent across the lifespan. |
| doi_str_mv | 10.1016/j.yfrne.2009.03.007 |
| format | Article |
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Many factors affect neurogenesis in the hippocampus and the subventricular zone, however the focus of this review will be on factors that affect hippocampal neurogenesis, particularly in females. Sex differences are often seen in levels of hippocampal neurogenesis, and these effects are due in part to differences in circulating levels of steroid hormones such as estradiol, progesterone, and corticosterone during the estrous cycle, in response to stress, with reproduction (including pregnancy and lactation), and aging. Depletion and administration of these same steroid hormones also has marked effects on hippocampal neurogenesis in the adult female, and these effects are dependent upon reproductive status and age. The present review will focus on current research investigating how hippocampal neurogenesis is altered in the adult female rodent across the lifespan.</description><identifier>ISSN: 0091-3022</identifier><identifier>EISSN: 1095-6808</identifier><identifier>DOI: 10.1016/j.yfrne.2009.03.007</identifier><identifier>PMID: 19361542</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult neurogenesis ; Adult Stem Cells - drug effects ; Adult Stem Cells - physiology ; Aging - drug effects ; Aging - physiology ; Animals ; Cell death ; Cell proliferation ; Cell survival ; Corticosterone ; Endocrinology & Metabolism ; Estrogen ; Estrous Cycle - drug effects ; Estrous Cycle - physiology ; Female ; Gonadal Steroid Hormones - pharmacology ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hippocampus - physiology ; Lactation - drug effects ; Lactation - physiology ; Neurogenesis - drug effects ; Postpartum ; Pregnancy ; Pregnancy, Animal ; Rodentia - metabolism ; Rodentia - physiology ; Stress</subject><ispartof>Frontiers in neuroendocrinology, 2009-08, Vol.30 (3), p.343-357</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-c606cae3345b5916450af9a031a014a176d2bd81e12a242fa9a512f39d3ed2d53</citedby><cites>FETCH-LOGICAL-c478t-c606cae3345b5916450af9a031a014a176d2bd81e12a242fa9a512f39d3ed2d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.yfrne.2009.03.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19361542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pawluski, Jodi L</creatorcontrib><creatorcontrib>Brummelte, Susanne</creatorcontrib><creatorcontrib>Barha, Cindy K</creatorcontrib><creatorcontrib>Crozier, Tamara M</creatorcontrib><creatorcontrib>Galea, Liisa A.M</creatorcontrib><title>Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging</title><title>Frontiers in neuroendocrinology</title><addtitle>Front Neuroendocrinol</addtitle><description>Abstract Adult neurogenesis exists in most mammalian species, including humans, in two main areas: the subventricular zone (new cells migrate to the olfactory bulbs) and the dentate gyrus of the hippocampus. Many factors affect neurogenesis in the hippocampus and the subventricular zone, however the focus of this review will be on factors that affect hippocampal neurogenesis, particularly in females. Sex differences are often seen in levels of hippocampal neurogenesis, and these effects are due in part to differences in circulating levels of steroid hormones such as estradiol, progesterone, and corticosterone during the estrous cycle, in response to stress, with reproduction (including pregnancy and lactation), and aging. Depletion and administration of these same steroid hormones also has marked effects on hippocampal neurogenesis in the adult female, and these effects are dependent upon reproductive status and age. The present review will focus on current research investigating how hippocampal neurogenesis is altered in the adult female rodent across the lifespan.</description><subject>Adult neurogenesis</subject><subject>Adult Stem Cells - drug effects</subject><subject>Adult Stem Cells - physiology</subject><subject>Aging - drug effects</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Cell death</subject><subject>Cell proliferation</subject><subject>Cell survival</subject><subject>Corticosterone</subject><subject>Endocrinology & Metabolism</subject><subject>Estrogen</subject><subject>Estrous Cycle - drug effects</subject><subject>Estrous Cycle - physiology</subject><subject>Female</subject><subject>Gonadal Steroid Hormones - pharmacology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiology</subject><subject>Lactation - drug effects</subject><subject>Lactation - physiology</subject><subject>Neurogenesis - drug effects</subject><subject>Postpartum</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal</subject><subject>Rodentia - metabolism</subject><subject>Rodentia - physiology</subject><subject>Stress</subject><issn>0091-3022</issn><issn>1095-6808</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk2LFDEQDaK4s6u_QJCcPG23laTTM31QkGVdhQUP6jlkkspMxu6kTbqF_hv-YjMfIHjxVFTVe_X1ipBXDGoGrH17qBeXAtYcoKtB1ADrJ2TFoJNVu4HNU7IqCVYJ4PyKXOd8gKMvmufkinWiZbLhK_L73jk0U6bR0Txhit7SfUxDDFhigQacU9xh8XymPtBpj3TvxzEaPYzziXYMaTv3E3U46B5pihbDRO2cfNid0pinFAvaLKbHWzom3AUdzHJLe20mPfnSSQdL9a4wXpBnTvcZX17sDfn-8f7b3afq8cvD57sPj5Vp1pupMi20RqMQjdzKjrWNBO06DYJpYI1m69byrd0wZFzzhjvdacm4E50VaLmV4oa8OdcdU_w5lxHV4LPBvtcBy7CqXcsGZNcUoDgDTYo5J3RqTH7QaVEM1FEKdVAnKdRRCgVCFSkK6_Wl_Lwd0P7lXG5fAO_OACxL_vKYVDYeg0HrU5FE2ej_0-D9P3zT--CN7n_ggvkQ5xTK_RRTmStQX0_ql2eArjwCSCH-ANxjsrY</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Pawluski, Jodi L</creator><creator>Brummelte, Susanne</creator><creator>Barha, Cindy K</creator><creator>Crozier, Tamara M</creator><creator>Galea, Liisa A.M</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090801</creationdate><title>Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging</title><author>Pawluski, Jodi L ; Brummelte, Susanne ; Barha, Cindy K ; Crozier, Tamara M ; Galea, Liisa A.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-c606cae3345b5916450af9a031a014a176d2bd81e12a242fa9a512f39d3ed2d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult neurogenesis</topic><topic>Adult Stem Cells - drug effects</topic><topic>Adult Stem Cells - physiology</topic><topic>Aging - drug effects</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Cell death</topic><topic>Cell proliferation</topic><topic>Cell survival</topic><topic>Corticosterone</topic><topic>Endocrinology & Metabolism</topic><topic>Estrogen</topic><topic>Estrous Cycle - drug effects</topic><topic>Estrous Cycle - physiology</topic><topic>Female</topic><topic>Gonadal Steroid Hormones - pharmacology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - physiology</topic><topic>Lactation - drug effects</topic><topic>Lactation - physiology</topic><topic>Neurogenesis - drug effects</topic><topic>Postpartum</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal</topic><topic>Rodentia - metabolism</topic><topic>Rodentia - physiology</topic><topic>Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pawluski, Jodi L</creatorcontrib><creatorcontrib>Brummelte, Susanne</creatorcontrib><creatorcontrib>Barha, Cindy K</creatorcontrib><creatorcontrib>Crozier, Tamara M</creatorcontrib><creatorcontrib>Galea, Liisa A.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Frontiers in neuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pawluski, Jodi L</au><au>Brummelte, Susanne</au><au>Barha, Cindy K</au><au>Crozier, Tamara M</au><au>Galea, Liisa A.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging</atitle><jtitle>Frontiers in neuroendocrinology</jtitle><addtitle>Front Neuroendocrinol</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>30</volume><issue>3</issue><spage>343</spage><epage>357</epage><pages>343-357</pages><issn>0091-3022</issn><eissn>1095-6808</eissn><abstract>Abstract Adult neurogenesis exists in most mammalian species, including humans, in two main areas: the subventricular zone (new cells migrate to the olfactory bulbs) and the dentate gyrus of the hippocampus. Many factors affect neurogenesis in the hippocampus and the subventricular zone, however the focus of this review will be on factors that affect hippocampal neurogenesis, particularly in females. Sex differences are often seen in levels of hippocampal neurogenesis, and these effects are due in part to differences in circulating levels of steroid hormones such as estradiol, progesterone, and corticosterone during the estrous cycle, in response to stress, with reproduction (including pregnancy and lactation), and aging. Depletion and administration of these same steroid hormones also has marked effects on hippocampal neurogenesis in the adult female, and these effects are dependent upon reproductive status and age. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult neurogenesis Adult Stem Cells - drug effects Adult Stem Cells - physiology Aging - drug effects Aging - physiology Animals Cell death Cell proliferation Cell survival Corticosterone Endocrinology & Metabolism Estrogen Estrous Cycle - drug effects Estrous Cycle - physiology Female Gonadal Steroid Hormones - pharmacology Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology Lactation - drug effects Lactation - physiology Neurogenesis - drug effects Postpartum Pregnancy Pregnancy, Animal Rodentia - metabolism Rodentia - physiology Stress |
| title | Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging |
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