Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

Commensal bacteria in the lower intestine of mammals are 10 times as numerous as the body's cells. We investigated the relative importance of different immune mechanisms in limiting the spread of the intestinal microbiota. Here, we reveal a flexible continuum between innate and adaptive immune...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2009-07, Vol.325 (5940), p.617-620
Hauptverfasser:	Slack, Emma, Hapfelmeier, Siegfried, Stecher, Bärbel, Velykoredko, Yuliya, Stoel, Maaike, Lawson, Melissa A.E, Geuking, Markus B, Beutler, Bruce, Tedder, Thomas F, Hardt, Wolf-Dietrich, Bercik, Premysl, Verdu, Elena F, McCoy, Kathy D, Macpherson, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Antibodies Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Bacteremia - immunology Bacteremia - microbiology Bacteria Bacteria - growth & development Bacteria - immunology Bacteria - isolation & purification Bacterial Infections - immunology Bacterial Infections - microbiology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Colon Colony Count, Microbial Commensals Enterococcus faecalis - growth & development Enterococcus faecalis - immunology Enterococcus faecalis - isolation & purification Escherichia coli K12 - growth & development Escherichia coli K12 - immunology Escherichia coli K12 - isolation & purification Fundamental and applied biological sciences. Psychology Fundamental immunology Germ free state Germ-Free Life Immune system Immunity Immunity, Innate Immunobiology Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestines - immunology Intestines - microbiology Lymph nodes Lymphoid Tissue - microbiology Mice Mice, Inbred C57BL Microbiota Mutualism Pathogens Permeability Respiratory Burst Rodents Signal Transduction Specific Pathogen-Free Organisms Spleen Spleen - microbiology Toll-Like Receptors - genetics Toll-Like Receptors - metabolism
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