Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor

ROS1 protein is a receptor tyrosine kinase that has been reported mainly in meningiomas and astrocytomas, and until now, there is no selective inhibitor for this kinase. In this study, we illustrate for the synthesis of a highly potent selective inhibitor for ROS1 kinase. The synthesized compound 1...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (16), p.4720-4723
Hauptverfasser:	Park, Byung Sun, El-Deeb, Ibrahim M., Yoo, Kyung Ho, Oh, Chang-Hyun, Cho, Seung Joo, Han, Dong Keun, Lee, Hye-Seung, Lee, Jae Yeol, Lee, So Ha
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Astrocytoma Astrocytoma - drug therapy Biological and medical sciences Cancer Drug Design General aspects Glioblastoma multiforme Humans Kinase inhibitor Medical sciences Pharmacology. Drug treatments Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Pyrazole Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology ROS1 Selectivity Tyrosine kinase
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