Genome-Wide Identification of Direct Target Genes Implicates Estrogen-Related Receptor α as a Determinant of Breast Cancer Heterogeneity

Estrogen-related receptor alpha (ERRalpha) is an orphan nuclear receptor, the expression of which correlates with negative prognosis in breast cancer. ERRalpha shares functional features with the estrogen receptor alpha (ERalpha) and its activity is modulated by the ERBB2 signaling pathway. Using ge...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-08, Vol.69 (15), p.6149-6157
Hauptverfasser:	DEBLOIS, Geneviève, HALL, Jacqueline A, PERRY, Marie-Claude, LAGANIERE, Josée, GHAHREMANI, Majid, PARK, Morag, HALLETT, Michael, GIGUERE, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Base Sequence Binding Sites Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor Chromatin Immunoprecipitation DNA, Neoplasm - metabolism ERRalpha Estrogen-Related Receptor Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Genome, Human Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Oligonucleotide Array Sequence Analysis - methods Pharmacology. Drug treatments Promoter Regions, Genetic Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Tumors
Online-Zugang:	Volltext
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