Relationship between healing time and mean perfusion units of laser Doppler imaging (LDI) in pediatric burns
Abstract Background Laser Doppler imaging (LDI) is a noninvasive technique used to assess burn depth. However, there have been no studies regarding the use of LDI in predicting burn healing time. Objectives The aims of this study are to evaluate the relationship between healing time and the amount o...
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description | Abstract Background Laser Doppler imaging (LDI) is a noninvasive technique used to assess burn depth. However, there have been no studies regarding the use of LDI in predicting burn healing time. Objectives The aims of this study are to evaluate the relationship between healing time and the amount of perfusion seen on LDI and to determine a cut-off value for LDI that predicts if a burn will heal within 14 days. Study design Consecutive patients younger than 15 years old with partial-thickness burns were recruited from May to November 2006 for this prospective observational study. The mean number of perfusion units (PU) as determined by LDI (Periscan PIM 3 system) was obtained within 2–3 days following injury. Healing time was estimated clinically by two physicians and marked by the observation of reepithelization. The mean PU was compared between the early (healed with 14 days) and late healing groups (healed later than 14 days). The usefulness of the mean PU in predicting healing time within 14 days was estimated by receiver operating characteristic curve analysis. Results A total of 103 patients with 181 partial-thickness burn wounds were enrolled in this study. The mean PU from LDI was higher in the early healing group compared to the late healing group (380.2 ± 157.8 vs. 185.8 ± 115.8, p < 0.001). When using 250 PUs as a cut-off value to predict early healing, the sensitivity and specificity were 80.6% and 76.9%, respectively. The area under the ROC curve was 0.844 ( p < 0.001, 95% CI = 0.780–0.908). Conclusions This study suggests the mean PU as determined by LDI can be used as a valuable tool in predicting the healing time of burn wounds. |
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fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67539574</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0305417908003963</els_id><sourcerecordid>67539574</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-9414f451e1a5dd43e5cacdd67b086dd70dda51e4b42ee3169363c3a3a1a51ec33</originalsourceid><addsrcrecordid>eNqFkk1rFTEUhoNY7LX6CwTJRtHFjDmTzNdCQVptCxcEP9Yhk5xpc81kpslMS_-9md5LBTdmcyB53pM3bw4hr4DlwKD6sMu7JfiYF4w1ORQ5Y-0TsoGmbjMQrH1KNoyzMhNQt8fkeYw7llbZsGfkGFpR8ILDhrjv6NRsRx-v7UQ7nO8QPb1G5ay_orMdkCpv6IDK0wlDv8TE0sXbOdKxp05FDPRsnCaXqh3U1Sp7tz27fE_tqjBWzcFq-mD1BTnqlYv48lBPyK-vX36eXmTbb-eXp5-3mRaimLNWgOhFCQiqNEZwLLXSxlR1x5rKmJoZo9Kp6ESByKFqecU1V1zBuq05PyFv932nMN4sGGc52KjROeVxXKKs6pK3ZS0SyPegDmOMAXs5hfSIcC-ByTVkuZMPzuUasoRCppCT6vWh_dINaP5qDqkm4M0BUFEr1wfltY2PXAGN4AVUifu45zCFcWsxyKgtep1SC6hnaUb7HyOf_tHr9G02Xfkb7zHuxqRIOUuQMQnkj3Ue1nFgDWO8rTj_A-lwsV0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67539574</pqid></control><display><type>article</type><title>Relationship between healing time and mean perfusion units of laser Doppler imaging (LDI) in pediatric burns</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Cho, Jin Kyung ; Moon, Duk Ju ; Kim, Seon Gyu ; Lee, Ha Guen ; Chung, Sung Pil ; Yoon, Cheon Jae</creator><creatorcontrib>Cho, Jin Kyung ; Moon, Duk Ju ; Kim, Seon Gyu ; Lee, Ha Guen ; Chung, Sung Pil ; Yoon, Cheon Jae</creatorcontrib><description>Abstract Background Laser Doppler imaging (LDI) is a noninvasive technique used to assess burn depth. However, there have been no studies regarding the use of LDI in predicting burn healing time. Objectives The aims of this study are to evaluate the relationship between healing time and the amount of perfusion seen on LDI and to determine a cut-off value for LDI that predicts if a burn will heal within 14 days. Study design Consecutive patients younger than 15 years old with partial-thickness burns were recruited from May to November 2006 for this prospective observational study. The mean number of perfusion units (PU) as determined by LDI (Periscan PIM 3 system) was obtained within 2–3 days following injury. Healing time was estimated clinically by two physicians and marked by the observation of reepithelization. The mean PU was compared between the early (healed with 14 days) and late healing groups (healed later than 14 days). The usefulness of the mean PU in predicting healing time within 14 days was estimated by receiver operating characteristic curve analysis. Results A total of 103 patients with 181 partial-thickness burn wounds were enrolled in this study. The mean PU from LDI was higher in the early healing group compared to the late healing group (380.2 ± 157.8 vs. 185.8 ± 115.8, p < 0.001). When using 250 PUs as a cut-off value to predict early healing, the sensitivity and specificity were 80.6% and 76.9%, respectively. The area under the ROC curve was 0.844 ( p < 0.001, 95% CI = 0.780–0.908). Conclusions This study suggests the mean PU as determined by LDI can be used as a valuable tool in predicting the healing time of burn wounds.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/j.burns.2008.12.009</identifier><identifier>PMID: 19423231</identifier><identifier>CODEN: BURND8</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Burn ; Burns ; Burns - diagnosis ; Burns - pathology ; Burns - physiopathology ; Cardiovascular system ; Child ; Child, Preschool ; Critical Care ; Female ; General aspects ; Humans ; Infant ; Investigative techniques, diagnostic techniques (general aspects) ; Laser Doppler imaging ; Laser-Doppler Flowmetry - methods ; Male ; Medical sciences ; Microcirculation - physiology ; Prognosis ; Prospective Studies ; Sensitivity and Specificity ; Skin - blood supply ; Time Factors ; Trauma Severity Indices ; Traumas. Diseases due to physical agents ; Ultrasonic investigative techniques ; Wound healing ; Wound Healing - physiology</subject><ispartof>Burns, 2009-09, Vol.35 (6), p.818-823</ispartof><rights>Elsevier Ltd and ISBI</rights><rights>2008 Elsevier Ltd and ISBI</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-9414f451e1a5dd43e5cacdd67b086dd70dda51e4b42ee3169363c3a3a1a51ec33</citedby><cites>FETCH-LOGICAL-c442t-9414f451e1a5dd43e5cacdd67b086dd70dda51e4b42ee3169363c3a3a1a51ec33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.burns.2008.12.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21843216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19423231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Jin Kyung</creatorcontrib><creatorcontrib>Moon, Duk Ju</creatorcontrib><creatorcontrib>Kim, Seon Gyu</creatorcontrib><creatorcontrib>Lee, Ha Guen</creatorcontrib><creatorcontrib>Chung, Sung Pil</creatorcontrib><creatorcontrib>Yoon, Cheon Jae</creatorcontrib><title>Relationship between healing time and mean perfusion units of laser Doppler imaging (LDI) in pediatric burns</title><title>Burns</title><addtitle>Burns</addtitle><description>Abstract Background Laser Doppler imaging (LDI) is a noninvasive technique used to assess burn depth. However, there have been no studies regarding the use of LDI in predicting burn healing time. Objectives The aims of this study are to evaluate the relationship between healing time and the amount of perfusion seen on LDI and to determine a cut-off value for LDI that predicts if a burn will heal within 14 days. Study design Consecutive patients younger than 15 years old with partial-thickness burns were recruited from May to November 2006 for this prospective observational study. The mean number of perfusion units (PU) as determined by LDI (Periscan PIM 3 system) was obtained within 2–3 days following injury. Healing time was estimated clinically by two physicians and marked by the observation of reepithelization. The mean PU was compared between the early (healed with 14 days) and late healing groups (healed later than 14 days). The usefulness of the mean PU in predicting healing time within 14 days was estimated by receiver operating characteristic curve analysis. Results A total of 103 patients with 181 partial-thickness burn wounds were enrolled in this study. The mean PU from LDI was higher in the early healing group compared to the late healing group (380.2 ± 157.8 vs. 185.8 ± 115.8, p < 0.001). When using 250 PUs as a cut-off value to predict early healing, the sensitivity and specificity were 80.6% and 76.9%, respectively. The area under the ROC curve was 0.844 ( p < 0.001, 95% CI = 0.780–0.908). Conclusions This study suggests the mean PU as determined by LDI can be used as a valuable tool in predicting the healing time of burn wounds.</description><subject>Biological and medical sciences</subject><subject>Burn</subject><subject>Burns</subject><subject>Burns - diagnosis</subject><subject>Burns - pathology</subject><subject>Burns - physiopathology</subject><subject>Cardiovascular system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Critical Care</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laser Doppler imaging</subject><subject>Laser-Doppler Flowmetry - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microcirculation - physiology</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Skin - blood supply</subject><subject>Time Factors</subject><subject>Trauma Severity Indices</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Ultrasonic investigative techniques</subject><subject>Wound healing</subject><subject>Wound Healing - physiology</subject><issn>0305-4179</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1rFTEUhoNY7LX6CwTJRtHFjDmTzNdCQVptCxcEP9Yhk5xpc81kpslMS_-9md5LBTdmcyB53pM3bw4hr4DlwKD6sMu7JfiYF4w1ORQ5Y-0TsoGmbjMQrH1KNoyzMhNQt8fkeYw7llbZsGfkGFpR8ILDhrjv6NRsRx-v7UQ7nO8QPb1G5ay_orMdkCpv6IDK0wlDv8TE0sXbOdKxp05FDPRsnCaXqh3U1Sp7tz27fE_tqjBWzcFq-mD1BTnqlYv48lBPyK-vX36eXmTbb-eXp5-3mRaimLNWgOhFCQiqNEZwLLXSxlR1x5rKmJoZo9Kp6ESByKFqecU1V1zBuq05PyFv932nMN4sGGc52KjROeVxXKKs6pK3ZS0SyPegDmOMAXs5hfSIcC-ByTVkuZMPzuUasoRCppCT6vWh_dINaP5qDqkm4M0BUFEr1wfltY2PXAGN4AVUifu45zCFcWsxyKgtep1SC6hnaUb7HyOf_tHr9G02Xfkb7zHuxqRIOUuQMQnkj3Ue1nFgDWO8rTj_A-lwsV0</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Cho, Jin Kyung</creator><creator>Moon, Duk Ju</creator><creator>Kim, Seon Gyu</creator><creator>Lee, Ha Guen</creator><creator>Chung, Sung Pil</creator><creator>Yoon, Cheon Jae</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Relationship between healing time and mean perfusion units of laser Doppler imaging (LDI) in pediatric burns</title><author>Cho, Jin Kyung ; Moon, Duk Ju ; Kim, Seon Gyu ; Lee, Ha Guen ; Chung, Sung Pil ; Yoon, Cheon Jae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-9414f451e1a5dd43e5cacdd67b086dd70dda51e4b42ee3169363c3a3a1a51ec33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Burn</topic><topic>Burns</topic><topic>Burns - diagnosis</topic><topic>Burns - pathology</topic><topic>Burns - physiopathology</topic><topic>Cardiovascular system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Critical Care</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Laser Doppler imaging</topic><topic>Laser-Doppler Flowmetry - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microcirculation - physiology</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Skin - blood supply</topic><topic>Time Factors</topic><topic>Trauma Severity Indices</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Ultrasonic investigative techniques</topic><topic>Wound healing</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Jin Kyung</creatorcontrib><creatorcontrib>Moon, Duk Ju</creatorcontrib><creatorcontrib>Kim, Seon Gyu</creatorcontrib><creatorcontrib>Lee, Ha Guen</creatorcontrib><creatorcontrib>Chung, Sung Pil</creatorcontrib><creatorcontrib>Yoon, Cheon Jae</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Jin Kyung</au><au>Moon, Duk Ju</au><au>Kim, Seon Gyu</au><au>Lee, Ha Guen</au><au>Chung, Sung Pil</au><au>Yoon, Cheon Jae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between healing time and mean perfusion units of laser Doppler imaging (LDI) in pediatric burns</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>35</volume><issue>6</issue><spage>818</spage><epage>823</epage><pages>818-823</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><coden>BURND8</coden><abstract>Abstract Background Laser Doppler imaging (LDI) is a noninvasive technique used to assess burn depth. However, there have been no studies regarding the use of LDI in predicting burn healing time. Objectives The aims of this study are to evaluate the relationship between healing time and the amount of perfusion seen on LDI and to determine a cut-off value for LDI that predicts if a burn will heal within 14 days. Study design Consecutive patients younger than 15 years old with partial-thickness burns were recruited from May to November 2006 for this prospective observational study. The mean number of perfusion units (PU) as determined by LDI (Periscan PIM 3 system) was obtained within 2–3 days following injury. Healing time was estimated clinically by two physicians and marked by the observation of reepithelization. The mean PU was compared between the early (healed with 14 days) and late healing groups (healed later than 14 days). The usefulness of the mean PU in predicting healing time within 14 days was estimated by receiver operating characteristic curve analysis. Results A total of 103 patients with 181 partial-thickness burn wounds were enrolled in this study. The mean PU from LDI was higher in the early healing group compared to the late healing group (380.2 ± 157.8 vs. 185.8 ± 115.8, p < 0.001). When using 250 PUs as a cut-off value to predict early healing, the sensitivity and specificity were 80.6% and 76.9%, respectively. The area under the ROC curve was 0.844 ( p < 0.001, 95% CI = 0.780–0.908). Conclusions This study suggests the mean PU as determined by LDI can be used as a valuable tool in predicting the healing time of burn wounds.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19423231</pmid><doi>10.1016/j.burns.2008.12.009</doi><tpages>6</tpages></addata></record> |
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subjects | Biological and medical sciences Burn Burns Burns - diagnosis Burns - pathology Burns - physiopathology Cardiovascular system Child Child, Preschool Critical Care Female General aspects Humans Infant Investigative techniques, diagnostic techniques (general aspects) Laser Doppler imaging Laser-Doppler Flowmetry - methods Male Medical sciences Microcirculation - physiology Prognosis Prospective Studies Sensitivity and Specificity Skin - blood supply Time Factors Trauma Severity Indices Traumas. Diseases due to physical agents Ultrasonic investigative techniques Wound healing Wound Healing - physiology |
title | Relationship between healing time and mean perfusion units of laser Doppler imaging (LDI) in pediatric burns |
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