Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity

The expression of tumor suppressor p73 is regulated at mRNA and protein levels. It has been shown that E2F1 acts as a transcriptional activator for p73. In this study, we have found that deregulated expression of E2F1 increases the mRNA level of p73, however, E2F1 promotes the degradation of p73. Im...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-09, Vol.387 (1), p.143-148
Hauptverfasser:	Ozaki, Toshinori, Okoshi, Rintaro, Ono, Sayaka, Kubo, Natsumi, Nakagawara, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor DNA Mutational Analysis DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E2F1 E2F1 Transcription Factor - genetics E2F1 Transcription Factor - metabolism Humans Immunoprecipitation MG-132 Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism p73 Proteasome Proteasome Endopeptidase Complex - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Deletion Trans-Activators Transcription, Genetic Tumor Protein p73 Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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