The Zinc Finger Ikaros Transcription Factor Regulates Pituitary Growth Hormone and Prolactin Gene Expression through Distinct Effects on Chromatin Accessibility

The Ikaros transcription factors perform critical functions in the control of lymphohematopoiesis and immune regulation. Family members contain multiple zinc fingers that mediate DNA binding but have also been implicated as part of a complex chromatin-remodeling network. We show here that Ikaros is...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2005-04, Vol.19 (4), p.1004-1011
Hauptverfasser:	Ezzat, Shereen, Yu, Shunjiang, Asa, Sylvia L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Animals Cells, Cultured Chromatin - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Female Gene Expression Regulation Growth Hormone - genetics Growth Hormone - metabolism Histone Deacetylase Inhibitors Histones - metabolism Hydroxamic Acids - pharmacology Ikaros Transcription Factor Mice Pituitary Gland - cytology Pituitary Gland - metabolism Prolactin - genetics Prolactin - metabolism Promoter Regions, Genetic Rats RNA, Messenger - analysis RNA, Messenger - metabolism Transcription Factor Pit-1 Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Zinc Fingers
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