Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition

In vertebrates, adipose tissue stores energy in the form of fat. Fat storage is tightly controlled by and dynamically balanced with energy expenditure under physiological settings; the perturbation of fat in either excess (obese) or deficit (lipodystrophy) has devastating pathologic consequences in...

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Veröffentlicht in:	Experimental cell research 2009-09, Vol.315 (15), p.2568-2580
Hauptverfasser:	Zhang, Jun, Yang, Chuan, Brey, Christopher, Rodriguez, Marilis, Oksov, Yelena, Gaugler, Randy, Dickstein, Ellen, Huang, Cheng-Han, Hashmi, Sarwar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - anatomy & histology Adipose Tissue - metabolism Amino Acid Sequence Animals Animals, Genetically Modified C. elegans Caenorhabditis elegans - anatomy & histology Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cellular biology Fat storage Fatty Acid Desaturases - metabolism Fatty acids Fatty Acids - chemistry Fatty Acids - metabolism Feedback Humans Intestines - metabolism klf-3 Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Krüppel-like factors Molecular Sequence Data Mutation Nematodes Phenotype Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Zinc finger
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