Transfusion of platelet components prepared with photochemical pathogen inactivation treatment during a Chikungunya virus epidemic in Ile de La Réunion
BACKGROUND: During the Chikungunya virus (CHIKV) epidemic on Ile de La Réunion, France, more than 30% of 750,000 inhabitants were infected. Local blood donation was suspended to prevent transfusion‐transmitted infection (TT‐CHIKV). To sustain the availability of platelet (PLT) components, the Établi...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2009-06, Vol.49 (6), p.1083-1091 |
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| creator | Rasonglès, Patrice Angelini-Tibert, Marie France Simon, Philip Currie, Caroline Isola, Herve Kientz, Daniel Slaedts, Marc Jacquet, Michele Sundin, David Lin, Lily Corash, Laurence Cazenave, Jean Pierre |
| description | BACKGROUND: During the Chikungunya virus (CHIKV) epidemic on Ile de La Réunion, France, more than 30% of 750,000 inhabitants were infected. Local blood donation was suspended to prevent transfusion‐transmitted infection (TT‐CHIKV). To sustain the availability of platelet (PLT) components, the Établissement Français du Sang implemented universal pathogen inactivation (INTERCEPT, Cerus Europe BV) of PLT components (CPAs). The study assessed the safety of PLT components treated with pathogen inactivation transfused in routine clinical practice.
STUDY DESIGN AND METHODS: This was a retrospective observational study using patient medical records and the AFSSAPS hemovigilance database (eFIT) to identify TT‐CHIKV and adverse events (AEs) classified as acute transfusion reactions (ATRs) to PLT components prepared with pathogen inactivation.
RESULTS: During 1 year, 1950 INTERCEPT‐CPAs were transfused to 335 adult, 51 pediatric, and 41 infant patients. Nineteen AEs were observed in 15 patients and 10 were classified as ATRs. Eight ATRs occurred in 6 pediatric hematology‐oncology patients. No ATRs were observed in infants. The most frequently reported signs and symptoms were Grade 1 urticaria, itching, chills, fever, and anxiety. No cases of transfusion‐related acute lung injury, TT‐sepsis, or TT‐CHIKV were detected.
CONCLUSIONS: INTERCEPT‐CPAs were well tolerated in a broad range of patients, including infants. ATR incidence was low and when present ATRs were of mild severity. |
| doi_str_mv | 10.1111/j.1537-2995.2009.02111.x |
| format | Article |
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STUDY DESIGN AND METHODS: This was a retrospective observational study using patient medical records and the AFSSAPS hemovigilance database (eFIT) to identify TT‐CHIKV and adverse events (AEs) classified as acute transfusion reactions (ATRs) to PLT components prepared with pathogen inactivation.
RESULTS: During 1 year, 1950 INTERCEPT‐CPAs were transfused to 335 adult, 51 pediatric, and 41 infant patients. Nineteen AEs were observed in 15 patients and 10 were classified as ATRs. Eight ATRs occurred in 6 pediatric hematology‐oncology patients. No ATRs were observed in infants. The most frequently reported signs and symptoms were Grade 1 urticaria, itching, chills, fever, and anxiety. No cases of transfusion‐related acute lung injury, TT‐sepsis, or TT‐CHIKV were detected.
CONCLUSIONS: INTERCEPT‐CPAs were well tolerated in a broad range of patients, including infants. ATR incidence was low and when present ATRs were of mild severity.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2009.02111.x</identifier><identifier>PMID: 19309473</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alphavirus Infections - epidemiology ; Alphavirus Infections - prevention & control ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood coagulation. Blood cells ; Blood Donors ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Chikungunya virus ; Chikungunya virus - drug effects ; Chikungunya virus - radiation effects ; Child ; Child, Preschool ; Female ; France - epidemiology ; Fundamental and applied biological sciences. Psychology ; Furocoumarins - pharmacology ; Humans ; Infant ; Infant, Newborn ; Male ; Medical sciences ; Middle Aged ; Molecular and cellular biology ; Photochemistry ; Platelet ; Platelet Transfusion - adverse effects ; Retrospective Studies ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Ultraviolet Rays</subject><ispartof>Transfusion (Philadelphia, Pa.), 2009-06, Vol.49 (6), p.1083-1091</ispartof><rights>2009 American Association of Blood Banks</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4671-9cb6aeadce9c7757753ee5cdd4142ec14c21b63aef20b14d7c1362701491f9ef3</citedby><cites>FETCH-LOGICAL-c4671-9cb6aeadce9c7757753ee5cdd4142ec14c21b63aef20b14d7c1362701491f9ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2009.02111.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2009.02111.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21615456$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19309473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasonglès, Patrice</creatorcontrib><creatorcontrib>Angelini-Tibert, Marie France</creatorcontrib><creatorcontrib>Simon, Philip</creatorcontrib><creatorcontrib>Currie, Caroline</creatorcontrib><creatorcontrib>Isola, Herve</creatorcontrib><creatorcontrib>Kientz, Daniel</creatorcontrib><creatorcontrib>Slaedts, Marc</creatorcontrib><creatorcontrib>Jacquet, Michele</creatorcontrib><creatorcontrib>Sundin, David</creatorcontrib><creatorcontrib>Lin, Lily</creatorcontrib><creatorcontrib>Corash, Laurence</creatorcontrib><creatorcontrib>Cazenave, Jean Pierre</creatorcontrib><title>Transfusion of platelet components prepared with photochemical pathogen inactivation treatment during a Chikungunya virus epidemic in Ile de La Réunion</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: During the Chikungunya virus (CHIKV) epidemic on Ile de La Réunion, France, more than 30% of 750,000 inhabitants were infected. Local blood donation was suspended to prevent transfusion‐transmitted infection (TT‐CHIKV). To sustain the availability of platelet (PLT) components, the Établissement Français du Sang implemented universal pathogen inactivation (INTERCEPT, Cerus Europe BV) of PLT components (CPAs). The study assessed the safety of PLT components treated with pathogen inactivation transfused in routine clinical practice.
STUDY DESIGN AND METHODS: This was a retrospective observational study using patient medical records and the AFSSAPS hemovigilance database (eFIT) to identify TT‐CHIKV and adverse events (AEs) classified as acute transfusion reactions (ATRs) to PLT components prepared with pathogen inactivation.
RESULTS: During 1 year, 1950 INTERCEPT‐CPAs were transfused to 335 adult, 51 pediatric, and 41 infant patients. Nineteen AEs were observed in 15 patients and 10 were classified as ATRs. Eight ATRs occurred in 6 pediatric hematology‐oncology patients. No ATRs were observed in infants. The most frequently reported signs and symptoms were Grade 1 urticaria, itching, chills, fever, and anxiety. No cases of transfusion‐related acute lung injury, TT‐sepsis, or TT‐CHIKV were detected.
CONCLUSIONS: INTERCEPT‐CPAs were well tolerated in a broad range of patients, including infants. ATR incidence was low and when present ATRs were of mild severity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alphavirus Infections - epidemiology</subject><subject>Alphavirus Infections - prevention & control</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Donors</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Chikungunya virus</subject><subject>Chikungunya virus - drug effects</subject><subject>Chikungunya virus - radiation effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Furocoumarins - pharmacology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Photochemistry</subject><subject>Platelet</subject><subject>Platelet Transfusion - adverse effects</subject><subject>Retrospective Studies</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Ultraviolet Rays</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd-OEyEUxidG49bVVzDc6N2MwPyh3JiYxq3rNpo0NV4Sypxp6c7ACMxu-ya-gs_hi8m0Tb1UQsIJfN-Pk_MlCSI4I3G922WkzFlKOS8zijHPMI3X2f5JMrk8PE0mGBckJSSnV8kL73cYY8oxeZ5cEZ5jXrB8kvxcOWl8M3htDbIN6lsZoIWAlO16a8AEj3oHvXRQo0cdtqjf2mDVFjqtZIt6GbZ2AwZpI1XQDzKMoOBAhi6aUT04bTZIotlW3w9mM5iDRA_aDR5Br-uREq3otgVUA1pItPz9azCR8TJ51sjWw6vzeZ18u_m4mn1KF1_nt7MPi1QVFSMpV-tKgqwVcMVYGXcOUKq6LkhBQZFCUbKucgkNxWtS1EyRvKIMk4KThkOTXydvT9ze2R8D-CA67RW0rTRgBy-qSKxwNf2nkB4z4FUUTk9C5az3DhrRO91JdxAEizE-sRNjSmJMSYzxiaNV7KP19fmPYd1B_dd4zisK3pwF0sfxNzE8pf1FR0lFyqIce3h_0j3qFg7_3YBYLW-OZQSkJ4D2AfYXgHT3cSI5K8X3L3PB5ndsuZx-Fnf5HxztyZY</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Rasonglès, Patrice</creator><creator>Angelini-Tibert, Marie France</creator><creator>Simon, Philip</creator><creator>Currie, Caroline</creator><creator>Isola, Herve</creator><creator>Kientz, Daniel</creator><creator>Slaedts, Marc</creator><creator>Jacquet, Michele</creator><creator>Sundin, David</creator><creator>Lin, Lily</creator><creator>Corash, Laurence</creator><creator>Cazenave, Jean Pierre</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Transfusion of platelet components prepared with photochemical pathogen inactivation treatment during a Chikungunya virus epidemic in Ile de La Réunion</title><author>Rasonglès, Patrice ; Angelini-Tibert, Marie France ; Simon, Philip ; Currie, Caroline ; Isola, Herve ; Kientz, Daniel ; Slaedts, Marc ; Jacquet, Michele ; Sundin, David ; Lin, Lily ; Corash, Laurence ; Cazenave, Jean Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4671-9cb6aeadce9c7757753ee5cdd4142ec14c21b63aef20b14d7c1362701491f9ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alphavirus Infections - epidemiology</topic><topic>Alphavirus Infections - prevention & control</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Donors</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Chikungunya virus</topic><topic>Chikungunya virus - drug effects</topic><topic>Chikungunya virus - radiation effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Furocoumarins - pharmacology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>Photochemistry</topic><topic>Platelet</topic><topic>Platelet Transfusion - adverse effects</topic><topic>Retrospective Studies</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasonglès, Patrice</creatorcontrib><creatorcontrib>Angelini-Tibert, Marie France</creatorcontrib><creatorcontrib>Simon, Philip</creatorcontrib><creatorcontrib>Currie, Caroline</creatorcontrib><creatorcontrib>Isola, Herve</creatorcontrib><creatorcontrib>Kientz, Daniel</creatorcontrib><creatorcontrib>Slaedts, Marc</creatorcontrib><creatorcontrib>Jacquet, Michele</creatorcontrib><creatorcontrib>Sundin, David</creatorcontrib><creatorcontrib>Lin, Lily</creatorcontrib><creatorcontrib>Corash, Laurence</creatorcontrib><creatorcontrib>Cazenave, Jean Pierre</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasonglès, Patrice</au><au>Angelini-Tibert, Marie France</au><au>Simon, Philip</au><au>Currie, Caroline</au><au>Isola, Herve</au><au>Kientz, Daniel</au><au>Slaedts, Marc</au><au>Jacquet, Michele</au><au>Sundin, David</au><au>Lin, Lily</au><au>Corash, Laurence</au><au>Cazenave, Jean Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transfusion of platelet components prepared with photochemical pathogen inactivation treatment during a Chikungunya virus epidemic in Ile de La Réunion</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2009-06</date><risdate>2009</risdate><volume>49</volume><issue>6</issue><spage>1083</spage><epage>1091</epage><pages>1083-1091</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: During the Chikungunya virus (CHIKV) epidemic on Ile de La Réunion, France, more than 30% of 750,000 inhabitants were infected. Local blood donation was suspended to prevent transfusion‐transmitted infection (TT‐CHIKV). To sustain the availability of platelet (PLT) components, the Établissement Français du Sang implemented universal pathogen inactivation (INTERCEPT, Cerus Europe BV) of PLT components (CPAs). The study assessed the safety of PLT components treated with pathogen inactivation transfused in routine clinical practice.
STUDY DESIGN AND METHODS: This was a retrospective observational study using patient medical records and the AFSSAPS hemovigilance database (eFIT) to identify TT‐CHIKV and adverse events (AEs) classified as acute transfusion reactions (ATRs) to PLT components prepared with pathogen inactivation.
RESULTS: During 1 year, 1950 INTERCEPT‐CPAs were transfused to 335 adult, 51 pediatric, and 41 infant patients. Nineteen AEs were observed in 15 patients and 10 were classified as ATRs. Eight ATRs occurred in 6 pediatric hematology‐oncology patients. No ATRs were observed in infants. The most frequently reported signs and symptoms were Grade 1 urticaria, itching, chills, fever, and anxiety. No cases of transfusion‐related acute lung injury, TT‐sepsis, or TT‐CHIKV were detected.
CONCLUSIONS: INTERCEPT‐CPAs were well tolerated in a broad range of patients, including infants. ATR incidence was low and when present ATRs were of mild severity.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19309473</pmid><doi>10.1111/j.1537-2995.2009.02111.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | Transfusion (Philadelphia, Pa.), 2009-06, Vol.49 (6), p.1083-1091 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Alphavirus Infections - epidemiology Alphavirus Infections - prevention & control Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood coagulation. Blood cells Blood Donors Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Chikungunya virus Chikungunya virus - drug effects Chikungunya virus - radiation effects Child Child, Preschool Female France - epidemiology Fundamental and applied biological sciences. Psychology Furocoumarins - pharmacology Humans Infant Infant, Newborn Male Medical sciences Middle Aged Molecular and cellular biology Photochemistry Platelet Platelet Transfusion - adverse effects Retrospective Studies Transfusions. Complications. Transfusion reactions. Cell and gene therapy Ultraviolet Rays |
| title | Transfusion of platelet components prepared with photochemical pathogen inactivation treatment during a Chikungunya virus epidemic in Ile de La Réunion |
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