Reference ranges and age-related changes of peripheral blood lymphocyte subsets in Chinese healthy adults
This study was performed to build region-specific reference ranges of peripheral blood lymphocyte subsets for Chinese healthy adults from the young to the elderly and analyze the trends of changes in lymphocyte subsets for evaluating the impact of age on the values.151 healthy adults aged 19-86 were...
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| Veröffentlicht in: | Science China. Life sciences 2009-07, Vol.52 (7), p.643-650 |
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| creator | Jiao, Yang Qiu, ZhiFeng Xie, Jing Li, DongJing Li, TaiSheng |
| description | This study was performed to build region-specific reference ranges of peripheral blood lymphocyte subsets for Chinese healthy adults from the young to the elderly and analyze the trends of changes in lymphocyte subsets for evaluating the impact of age on the values.151 healthy adults aged 19-86 were recruited based on the SENIEUR protocol.Three sets of reference ranges were finally built applicable for the healthy young(19-44 years),middle-aged(45-64 years) and elder adults(≥65).Comparisons in parameters among the three cohorts showed that a statistically significant increase in CD16CD56+ NK cell was observed between the middle-aged and elder cohorts,whereas for the majority of the parameters,a significant decline was observed between the young and the middle-aged cohorts.Further results showed that inverse correlations were observed between the age and CD19+ B,CD3+ T,CD3+CD4+ T,CD4+CD45RA+CD62L+ nave T cell and CD4+CD28+/CD4+,while the positive one was identified between the age and the NK cell.These significant changes of the most of immune parameters provided evidence for immunosenescence.Notably,T cell activation markers of CD8+CD38+ and CD8+HLA-DR+ showed reverse trends of association with age,which provides a clue for further researches on the mechanisms underlying the paradoxical clinical presentation of the elder patients. |
| doi_str_mv | 10.1007/s11427-009-0086-4 |
| format | Article |
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Life sciences, 2009-07, Vol.52 (7), p.643-650</ispartof><rights>Science in China Press and Springer-Verlag GmbH 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-1b67c0cd9a11bcdca59bec9e99ae32ec394ca6e68eaf5fd2d16fe6e39e23780b3</citedby><cites>FETCH-LOGICAL-c504t-1b67c0cd9a11bcdca59bec9e99ae32ec394ca6e68eaf5fd2d16fe6e39e23780b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60112X/60112X.jpg</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19641869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiao, Yang</creatorcontrib><creatorcontrib>Qiu, ZhiFeng</creatorcontrib><creatorcontrib>Xie, Jing</creatorcontrib><creatorcontrib>Li, DongJing</creatorcontrib><creatorcontrib>Li, TaiSheng</creatorcontrib><title>Reference ranges and age-related changes of peripheral blood lymphocyte subsets in Chinese healthy adults</title><title>Science China. Life sciences</title><addtitle>SCI CHINA SER C</addtitle><addtitle>Science China: Life Science</addtitle><description>This study was performed to build region-specific reference ranges of peripheral blood lymphocyte subsets for Chinese healthy adults from the young to the elderly and analyze the trends of changes in lymphocyte subsets for evaluating the impact of age on the values.151 healthy adults aged 19-86 were recruited based on the SENIEUR protocol.Three sets of reference ranges were finally built applicable for the healthy young(19-44 years),middle-aged(45-64 years) and elder adults(≥65).Comparisons in parameters among the three cohorts showed that a statistically significant increase in CD16CD56+ NK cell was observed between the middle-aged and elder cohorts,whereas for the majority of the parameters,a significant decline was observed between the young and the middle-aged cohorts.Further results showed that inverse correlations were observed between the age and CD19+ B,CD3+ T,CD3+CD4+ T,CD4+CD45RA+CD62L+ nave T cell and CD4+CD28+/CD4+,while the positive one was identified between the age and the NK cell.These significant changes of the most of immune parameters provided evidence for immunosenescence.Notably,T cell activation markers of CD8+CD38+ and CD8+HLA-DR+ showed reverse trends of association with age,which provides a clue for further researches on the mechanisms underlying the paradoxical clinical presentation of the elder patients.</description><subject>Adult</subject><subject>age</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Antigens, CD - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-CD8 Ratio</subject><subject>CD8-Positive T-Lymphocytes - cytology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>China</subject><subject>Female</subject><subject>Humans</subject><subject>immunosenescence</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Life Sciences</subject><subject>lymphocyte</subject><subject>Lymphocyte Subsets - cytology</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>range</subject><subject>Reference Values</subject><subject>subsets</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - immunology</subject><subject>Young Adult</subject><issn>1674-7305</issn><issn>1006-9305</issn><issn>1869-1889</issn><issn>1862-2798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1rFTEUhoMottT-ADcSFKSb0Xx_LOWiVSgIouuQSc7cmTJ3Mk1mFvffN5e5UHFRAyGH5Dlv3uRF6C0lnygh-nOhVDDdEGLrNKoRL9AlNco21Bj7stZKi0ZzIi_QdSn3pA7OCdP6NbqgVokTe4mGX9BBhikAzn7aQ8F-itjvockw-gUiDv22nzo8Qx7mHrIfcTumFPF4PMx9CscFcFnbAkvBw4R3_TBBAdyDH5f-iH1cx6W8Qa86Pxa4Pq9X6M-3r79335u7n7c_dl_umiCJWBraKh1IiNZT2oYYvLQtBAvWeuAMArcieAXKgO9kF1mkqgMF3ALj2pCWX6GPm-6c08MKZXGHoQQYRz9BWotTWnJpuPgvyCgjmlFSwZtnQWo4Y9U8YRV9_w96n9Y81fc6xoTUUhheIbpBIadSMnRuzsPB56OjxJ2ydVu2rmbrTtm6k9l3Z-G1PUB86jgnWQG2AaUe1cDy083PqX44O-nTtH-ofX9ZIVyY-lmSPwJJOrs3</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Jiao, Yang</creator><creator>Qiu, ZhiFeng</creator><creator>Xie, Jing</creator><creator>Li, DongJing</creator><creator>Li, TaiSheng</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Reference ranges and age-related changes of peripheral blood lymphocyte subsets in Chinese healthy adults</title><author>Jiao, Yang ; 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Life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiao, Yang</au><au>Qiu, ZhiFeng</au><au>Xie, Jing</au><au>Li, DongJing</au><au>Li, TaiSheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reference ranges and age-related changes of peripheral blood lymphocyte subsets in Chinese healthy adults</atitle><jtitle>Science China. Life sciences</jtitle><stitle>SCI CHINA SER C</stitle><addtitle>Science China: Life Science</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>52</volume><issue>7</issue><spage>643</spage><epage>650</epage><pages>643-650</pages><issn>1674-7305</issn><issn>1006-9305</issn><eissn>1869-1889</eissn><eissn>1862-2798</eissn><abstract>This study was performed to build region-specific reference ranges of peripheral blood lymphocyte subsets for Chinese healthy adults from the young to the elderly and analyze the trends of changes in lymphocyte subsets for evaluating the impact of age on the values.151 healthy adults aged 19-86 were recruited based on the SENIEUR protocol.Three sets of reference ranges were finally built applicable for the healthy young(19-44 years),middle-aged(45-64 years) and elder adults(≥65).Comparisons in parameters among the three cohorts showed that a statistically significant increase in CD16CD56+ NK cell was observed between the middle-aged and elder cohorts,whereas for the majority of the parameters,a significant decline was observed between the young and the middle-aged cohorts.Further results showed that inverse correlations were observed between the age and CD19+ B,CD3+ T,CD3+CD4+ T,CD4+CD45RA+CD62L+ nave T cell and CD4+CD28+/CD4+,while the positive one was identified between the age and the NK cell.These significant changes of the most of immune parameters provided evidence for immunosenescence.Notably,T cell activation markers of CD8+CD38+ and CD8+HLA-DR+ showed reverse trends of association with age,which provides a clue for further researches on the mechanisms underlying the paradoxical clinical presentation of the elder patients.</abstract><cop>Beijing</cop><pub>Science China Press</pub><pmid>19641869</pmid><doi>10.1007/s11427-009-0086-4</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Science China. Life sciences, 2009-07, Vol.52 (7), p.643-650 |
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| subjects | Adult age Aged Aging - physiology Antigens, CD - analysis Biomedical and Life Sciences CD4 Lymphocyte Count CD4-CD8 Ratio CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology China Female Humans immunosenescence Killer Cells, Natural - cytology Killer Cells, Natural - immunology Life Sciences lymphocyte Lymphocyte Subsets - cytology Lymphocyte Subsets - immunology Male Middle Aged range Reference Values subsets T-Lymphocytes - cytology T-Lymphocytes - immunology Young Adult |
| title | Reference ranges and age-related changes of peripheral blood lymphocyte subsets in Chinese healthy adults |
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