Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay

The effect of 32 flavonoids on androgen (AR) and glucocorticoid receptors (GR) was investigated using an MDA-kb2 human breast cancer cell line to predict potential AR and GR activities. Among them, 5-hydroxyflavone ( 7) had the highest AR antagonistic activity with an IC 50 value of 0.3 μM, whereas...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (16), p.4706-4710
Hauptverfasser:	Nishizaki, Yosuke, Ishimoto, Yoichi, Hotta, Yudai, Hosoda, Akifumi, Yoshikawa, Hiromichi, Akamatsu, Miki, Tamura, Hiroto
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Androgen Receptor Antagonists Androgens Antiandrogen Biological and medical sciences Cell Line, Tumor Flavonoid Flavonoids - chemistry Flavonoids - pharmacology Genes, Reporter - genetics Glucocorticoid Hormones. Endocrine system Humans Medical sciences Pharmacology. Drug treatments Receptors, Androgen - metabolism Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - metabolism Structure-Activity Relationship
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