Effect of a booster dose of serogroup B meningococcal vaccine on antibody response to Neisseria meningitidis in mice vaccinated with different immunization schedules
The generation and maintenance of memory antibody response by different primary immunization schedules with the Cuban-produced outer membrane protein based vaccine was investigated in a murine model. We analyzed the duration of the antibody response (IgG-ELISA and bactericidal titer) and the effect...
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| Veröffentlicht in: | FEMS immunology and medical microbiology 2005-04, Vol.44 (1), p.35-42 |
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| creator | Gioia, Carolina A.C. de Sousa, Adriana B. Cruz, Simone C. Junior, Feliciano C.S. Andrade, Arnaldo F.B. Sassi, Raul M. Frasch, Carl E. Milagres, Lucimar G. |
| description | The generation and maintenance of memory antibody response by different primary immunization schedules with the Cuban-produced outer membrane protein based vaccine was investigated in a murine model. We analyzed the duration of the antibody response (IgG-ELISA and bactericidal titer) and the effect of a booster dose on the antibody response. The IgG avidity index was determined in an attempt to find a marker for memory development. This study also included an analysis of IgG subclasses induced by primary and booster immunization. The specificity of bactericidal antibodies was investigated using local strains of the same serotype/serosubtype (4,7:P1.19,15) as the vaccine strain and mutant strains lacking major outer membrane proteins. A significant recall response was induced by a booster dose given 7 months after a primary series of 2, 3 or 4 doses of vaccine. The primary antibody response showed a positive dose-effect. In contrast, a negative dose-effect was found on the booster bactericidal antibody response. There was a significant increase in IgG1 levels after the fourth and booster doses. Three doses of vaccine were required to induce a significant increase in IgG avidity. Two injections of vaccine induced a significant antibody response to PorA protein, while 4 injections induced a larger range of specificities. |
| doi_str_mv | 10.1016/j.femsim.2004.11.013 |
| format | Article |
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We analyzed the duration of the antibody response (IgG-ELISA and bactericidal titer) and the effect of a booster dose on the antibody response. The IgG avidity index was determined in an attempt to find a marker for memory development. This study also included an analysis of IgG subclasses induced by primary and booster immunization. The specificity of bactericidal antibodies was investigated using local strains of the same serotype/serosubtype (4,7:P1.19,15) as the vaccine strain and mutant strains lacking major outer membrane proteins. A significant recall response was induced by a booster dose given 7 months after a primary series of 2, 3 or 4 doses of vaccine. The primary antibody response showed a positive dose-effect. In contrast, a negative dose-effect was found on the booster bactericidal antibody response. There was a significant increase in IgG1 levels after the fourth and booster doses. Three doses of vaccine were required to induce a significant increase in IgG avidity. Two injections of vaccine induced a significant antibody response to PorA protein, while 4 injections induced a larger range of specificities.</description><identifier>ISSN: 0928-8244</identifier><identifier>EISSN: 1574-695X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1016/j.femsim.2004.11.013</identifier><identifier>PMID: 15780576</identifier><language>eng</language><publisher>Oxford, UK: Elsevier B.V</publisher><subject>Animal models ; Animals ; Antibodies ; Antibodies, Bacterial - biosynthesis ; Antibodies, Bacterial - blood ; Antibody Affinity ; Antibody response ; Applied microbiology ; Avidity ; Bacterial Outer Membrane Proteins - immunology ; Bactericidal antibody and serological memory ; Bacteriology ; Biological and medical sciences ; Blood Bactericidal Activity ; Enzyme-linked immunosorbent assay ; Female ; Fundamental and applied biological sciences. Psychology ; Immunization ; Immunization Schedule ; Immunization, Secondary ; Immunoglobulin G ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - blood ; Immunoglobulin G - classification ; Immunologic Memory ; Immunological memory ; Kinetics ; Maintenance ; Membrane proteins ; Membranes ; Meningococcal Vaccines - administration & dosage ; Mice ; Microbiology ; Miscellaneous ; Neisseria meningitidis ; Neisseria meningitidis - immunology ; Outer membrane proteins ; Proteins ; Schedules ; Vaccine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>FEMS immunology and medical microbiology, 2005-04, Vol.44 (1), p.35-42</ispartof><rights>2005 Federation of European Microbiological Societies</rights><rights>2005 Federation of European Microbiological Societies 2005</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5375-198d2702ffbaf855e5b1ba6b6fe602554983e3e52fab37b219bf42c98a903c223</citedby><cites>FETCH-LOGICAL-c5375-198d2702ffbaf855e5b1ba6b6fe602554983e3e52fab37b219bf42c98a903c223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.femsim.2004.11.013$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.femsim.2004.11.013$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16659931$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15780576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gioia, Carolina A.C.</creatorcontrib><creatorcontrib>de Sousa, Adriana B.</creatorcontrib><creatorcontrib>Cruz, Simone C.</creatorcontrib><creatorcontrib>Junior, Feliciano C.S.</creatorcontrib><creatorcontrib>Andrade, Arnaldo F.B.</creatorcontrib><creatorcontrib>Sassi, Raul M.</creatorcontrib><creatorcontrib>Frasch, Carl E.</creatorcontrib><creatorcontrib>Milagres, Lucimar G.</creatorcontrib><title>Effect of a booster dose of serogroup B meningococcal vaccine on antibody response to Neisseria meningitidis in mice vaccinated with different immunization schedules</title><title>FEMS immunology and medical microbiology</title><addtitle>FEMS Immunol Med Microbiol</addtitle><description>The generation and maintenance of memory antibody response by different primary immunization schedules with the Cuban-produced outer membrane protein based vaccine was investigated in a murine model. We analyzed the duration of the antibody response (IgG-ELISA and bactericidal titer) and the effect of a booster dose on the antibody response. The IgG avidity index was determined in an attempt to find a marker for memory development. This study also included an analysis of IgG subclasses induced by primary and booster immunization. The specificity of bactericidal antibodies was investigated using local strains of the same serotype/serosubtype (4,7:P1.19,15) as the vaccine strain and mutant strains lacking major outer membrane proteins. A significant recall response was induced by a booster dose given 7 months after a primary series of 2, 3 or 4 doses of vaccine. The primary antibody response showed a positive dose-effect. In contrast, a negative dose-effect was found on the booster bactericidal antibody response. There was a significant increase in IgG1 levels after the fourth and booster doses. Three doses of vaccine were required to induce a significant increase in IgG avidity. Two injections of vaccine induced a significant antibody response to PorA protein, while 4 injections induced a larger range of specificities.</description><subject>Animal models</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibody Affinity</subject><subject>Antibody response</subject><subject>Applied microbiology</subject><subject>Avidity</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Bactericidal antibody and serological memory</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Blood Bactericidal Activity</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Immunization, Secondary</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - classification</subject><subject>Immunologic Memory</subject><subject>Immunological memory</subject><subject>Kinetics</subject><subject>Maintenance</subject><subject>Membrane proteins</subject><subject>Membranes</subject><subject>Meningococcal Vaccines - administration & dosage</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - immunology</subject><subject>Outer membrane proteins</subject><subject>Proteins</subject><subject>Schedules</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0928-8244</issn><issn>1574-695X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl1rFDEUhgdR7Fr9ByIB0bvd5mMyM7kRamm1UPVGwbuQyZy0Z5lJ1mSmZf0__k-zzkDBC-1VIDzPmxPeUxQvGd0wyqqT7cbBkHDYcErLDWMbysSjYsVkXa4rJb8_LlZU8Wbd8LI8Kp6ltKUZVJQ-LY4y1FBZV6vi17lzYEcSHDGkDSGNEEkXEhxuEsRwHcO0I-_JAB79dbDBWtOTW2Mt-gx5YvyIbej2JELaBZ_NMZDPgCnbaBYPR-wwEfRkQAuLbkboyB2ON6TDPEUEPxIchsnjTzNijk72Brqph_S8eOJMn-DFch4X3y7Ov559XF99-XB5dnq1tlLUcs1U0_Gacuda4xopQbasNVVbOagol7JUjQABkjvTirrlTLWu5FY1RlFhORfHxds5dxfDjwnSqAdMFvreeAhT0lUtBZOs-S_IaskrpQ7g67_AbZiiz5_QXNCalbwSMlPlTNkYUorg9C7iYOJeM6oPbeutntvWh7Y1Yzq3nbVXS_jUDtDdS0u9GXizACbl2lw03mK656pKKiVY5uqZu8Me9g96XF9cfvoz-cls5i156NDvZgNykbcIUSeL4C10GPMm6i7gvwN-A0RZ7cE</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Gioia, Carolina A.C.</creator><creator>de Sousa, Adriana B.</creator><creator>Cruz, Simone C.</creator><creator>Junior, Feliciano C.S.</creator><creator>Andrade, Arnaldo F.B.</creator><creator>Sassi, Raul M.</creator><creator>Frasch, Carl E.</creator><creator>Milagres, Lucimar G.</creator><general>Elsevier B.V</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7QL</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>Effect of a booster dose of serogroup B meningococcal vaccine on antibody response to Neisseria meningitidis in mice vaccinated with different immunization schedules</title><author>Gioia, Carolina A.C. ; de Sousa, Adriana B. ; Cruz, Simone C. ; Junior, Feliciano C.S. ; Andrade, Arnaldo F.B. ; Sassi, Raul M. ; Frasch, Carl E. ; Milagres, Lucimar G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5375-198d2702ffbaf855e5b1ba6b6fe602554983e3e52fab37b219bf42c98a903c223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibody Affinity</topic><topic>Antibody response</topic><topic>Applied microbiology</topic><topic>Avidity</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Bactericidal antibody and serological memory</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Blood Bactericidal Activity</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Immunization, Secondary</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - classification</topic><topic>Immunologic Memory</topic><topic>Immunological memory</topic><topic>Kinetics</topic><topic>Maintenance</topic><topic>Membrane proteins</topic><topic>Membranes</topic><topic>Meningococcal Vaccines - administration & dosage</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - immunology</topic><topic>Outer membrane proteins</topic><topic>Proteins</topic><topic>Schedules</topic><topic>Vaccine</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gioia, Carolina A.C.</creatorcontrib><creatorcontrib>de Sousa, Adriana B.</creatorcontrib><creatorcontrib>Cruz, Simone C.</creatorcontrib><creatorcontrib>Junior, Feliciano C.S.</creatorcontrib><creatorcontrib>Andrade, Arnaldo F.B.</creatorcontrib><creatorcontrib>Sassi, Raul M.</creatorcontrib><creatorcontrib>Frasch, Carl E.</creatorcontrib><creatorcontrib>Milagres, Lucimar G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS immunology and medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gioia, Carolina A.C.</au><au>de Sousa, Adriana B.</au><au>Cruz, Simone C.</au><au>Junior, Feliciano C.S.</au><au>Andrade, Arnaldo F.B.</au><au>Sassi, Raul M.</au><au>Frasch, Carl E.</au><au>Milagres, Lucimar G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a booster dose of serogroup B meningococcal vaccine on antibody response to Neisseria meningitidis in mice vaccinated with different immunization schedules</atitle><jtitle>FEMS immunology and medical microbiology</jtitle><addtitle>FEMS Immunol Med Microbiol</addtitle><date>2005-04</date><risdate>2005</risdate><volume>44</volume><issue>1</issue><spage>35</spage><epage>42</epage><pages>35-42</pages><issn>0928-8244</issn><eissn>1574-695X</eissn><eissn>2049-632X</eissn><abstract>The generation and maintenance of memory antibody response by different primary immunization schedules with the Cuban-produced outer membrane protein based vaccine was investigated in a murine model. We analyzed the duration of the antibody response (IgG-ELISA and bactericidal titer) and the effect of a booster dose on the antibody response. The IgG avidity index was determined in an attempt to find a marker for memory development. This study also included an analysis of IgG subclasses induced by primary and booster immunization. The specificity of bactericidal antibodies was investigated using local strains of the same serotype/serosubtype (4,7:P1.19,15) as the vaccine strain and mutant strains lacking major outer membrane proteins. A significant recall response was induced by a booster dose given 7 months after a primary series of 2, 3 or 4 doses of vaccine. The primary antibody response showed a positive dose-effect. In contrast, a negative dose-effect was found on the booster bactericidal antibody response. There was a significant increase in IgG1 levels after the fourth and booster doses. Three doses of vaccine were required to induce a significant increase in IgG avidity. Two injections of vaccine induced a significant antibody response to PorA protein, while 4 injections induced a larger range of specificities.</abstract><cop>Oxford, UK</cop><pub>Elsevier B.V</pub><pmid>15780576</pmid><doi>10.1016/j.femsim.2004.11.013</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Animal models Animals Antibodies Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood Antibody Affinity Antibody response Applied microbiology Avidity Bacterial Outer Membrane Proteins - immunology Bactericidal antibody and serological memory Bacteriology Biological and medical sciences Blood Bactericidal Activity Enzyme-linked immunosorbent assay Female Fundamental and applied biological sciences. Psychology Immunization Immunization Schedule Immunization, Secondary Immunoglobulin G Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G - classification Immunologic Memory Immunological memory Kinetics Maintenance Membrane proteins Membranes Meningococcal Vaccines - administration & dosage Mice Microbiology Miscellaneous Neisseria meningitidis Neisseria meningitidis - immunology Outer membrane proteins Proteins Schedules Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Effect of a booster dose of serogroup B meningococcal vaccine on antibody response to Neisseria meningitidis in mice vaccinated with different immunization schedules |
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