Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis

This study was designed to determine whether overexpression of the enzyme dimethylarginine dimethylaminohydrolase (DDAH) could enhance angiogenesis by reducing levels of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA). In DDAH1 transgenic (TG) and wild-type mi...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2005-03, Vol.111 (11), p.1431-1438
Hauptverfasser:	JACOBI, Johannes, SYDOW, Karsten, VON DEGENFELD, Georges, YING ZHANG, DAYOUB, Hayan, BINGYIN WANG, PATTERSON, Andrew J, KIMOTO, Masumi, BLAU, Helen M, COOKE, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - genetics Amidohydrolases - physiology Animals Arginine - analogs & derivatives Arginine - blood Arginine - pharmacokinetics Arginine - pharmacology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Enzyme Induction Female Heart Hindlimb - blood supply Humans Ischemia - physiopathology Laser-Doppler Flowmetry Medical sciences Mice Mice, Transgenic Microspheres Muscle, Skeletal - blood supply Neovascularization, Physiologic - physiology NG-Nitroarginine Methyl Ester - pharmacology Nitrates - blood Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitrites - blood Pharmacology. Drug treatments Prostheses and Implants Recombinant Fusion Proteins - physiology Vasodilator agents. Cerebral vasodilators
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