Inhibition of tumor formation by snake venom disintegrin

The metastasis of tumor cells to bone involves migration, invasion and adhesion to bone. Breast and prostate cancer cells have predilection for spreading to bone. Snake venom-derived arginine-glycine-aspartic acid (RGD)-containing disintegrins (e.g. rhodostomin) have been demonstrated to inhibit cel...

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Veröffentlicht in:	Toxicon (Oxford) 2005-04, Vol.45 (5), p.661-669
Hauptverfasser:	Yang, Rong-Sen, Tang, Chih-Hsin, Chuang, Woei-Jer, Huang, Tsang-Hai, Peng, Hui-Chin, Huang, Tur-Fu, Fu, Wen-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Bone Neoplasms - drug therapy Bone Neoplasms - secondary Breast Neoplasms - physiopathology Cancer cell Cell Adhesion - drug effects Cell Movement - drug effects Chemotherapy Disintegrin Disintegrins - pharmacology Disintegrins - therapeutic use Dose-Response Relationship, Drug Extracellular Matrix - metabolism Female Flow Cytometry Fluorescence Humans Integrin Male Medical sciences Metastasis Mice Mice, Nude Neoplasm Invasiveness - prevention & control Peptides - pharmacology Pharmacology. Drug treatments Prostatic Neoplasms - physiopathology Rats Tibia - pathology Tumor Cells, Cultured
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