Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease's airways

Reactive oxygen species have been reported to be involved in the airway inflammatory process of chronic obstructive pulmonary disease (COPD). The aim of this study was to quantify the activity of xanthine oxidase (XO), which generates a potent radical superoxide anion in COPD airways. Thirteen stabl...

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Veröffentlicht in:	Pulmonary pharmacology & therapeutics 2005-01, Vol.18 (4), p.297-302
Hauptverfasser:	Komaki, Yuichi, Sugiura, Hisatoshi, Koarai, Akira, Tomaki, Masafumi, Ogawa, Hiromasa, Akita, Takefumi, Hattori, Toshio, Ichinose, Masakazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoscopy - methods Cytokines - metabolism Female Forced Expiratory Volume Humans IFN-γ IL-1β Inflammation Mediators - metabolism Interleukin-1 - metabolism Male Middle Aged Oxidative stress Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory System - metabolism Respiratory System - pathology Respiratory System - physiopathology Superoxide TNF-α Tumor Necrosis Factor-alpha - metabolism Up-Regulation Xanthine Oxidase - metabolism Xanthopterin - metabolism
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