Pharmacokinetics and biodistribution of RGD-targeted doxorubicin-loaded nanoparticles in tumor-bearing mice

We report the biodistribution and pharmacokinetics (PK) of a cyclic RGD-doxorubicin-nanoparticle (NP) formulation in tumor-bearing mice. The NP core was composed of inulin multi-methacrylate with a targeting peptide, cyclic RGD, covalently attached to the NPs via PEG-400. Seventy-two percent of the...

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Veröffentlicht in:	International journal of pharmaceutics 2005-04, Vol.293 (1), p.281-290
Hauptverfasser:	Bibby, David C., Talmadge, James E., Dalal, Milind K., Kurz, Scott G., Chytil, Kevin M., Barry, Stephen E., Shand, David G., Steiert, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biodistribution Biological and medical sciences Doxorubicin Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug Delivery Systems - methods Drug Screening Assays, Antitumor - methods Female General pharmacology Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Medical sciences Mice Mice, Inbred BALB C Nanoparticles Nanostructures Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments Tissue Distribution - drug effects Tissue Distribution - physiology
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