Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

OX40 (CD134) is a member of the tumor necrosis factor (TNF) receptor family that is transiently expressed on T cells after T-cell receptor (TCR) ligation. Both naive and activated CD4+CD25+ regulatory T cells (T reg's) express OX40 but its functional role has not been determined. Since glucocor...

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Veröffentlicht in:	Blood 2005-04, Vol.105 (7), p.2845-2851
Hauptverfasser:	Valzasina, Barbara, Guiducci, Cristiana, Dislich, Heidrun, Killeen, Nigel, Weinberg, Andrew D., Colombo, Mario P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Division - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Glucocorticoid-Induced TNFR-Related Protein Graft vs Host Disease - immunology Graft vs Host Disease - metabolism Immunobiology Interleukin-2 - metabolism Lymphocyte Activation - physiology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Mutant Strains Modulation of the immune response (stimulation, suppression) Rats Rats, Wistar Receptors, Interleukin-2 - metabolism Receptors, Nerve Growth Factor - immunology Receptors, Nerve Growth Factor - metabolism Receptors, OX40 Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - immunology Receptors, Tumor Necrosis Factor - metabolism Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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