Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa
Low bone mineral density (BMD) is a frequent, often persistent complication in patients with major depressive disorder (MDD) and anorexia nervosa (AN) that increases the risk of pathologic fractures. The pathogenetic process underlying osteopenia in MDD and AN is still unclear, although several fact...
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| Veröffentlicht in: | Osteoporosis international 2005-04, Vol.16 (4), p.424-429 |
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| creator | KAHL, Kai G RUDOLF, Sebastian DIBBELT, Leif STOECKELHUBER, Beate M GEHL, Hans-Björn HOHAGEN, Fritz SCHWEIGER, Ulrich |
| description | Low bone mineral density (BMD) is a frequent, often persistent complication in patients with major depressive disorder (MDD) and anorexia nervosa (AN) that increases the risk of pathologic fractures. The pathogenetic process underlying osteopenia in MDD and AN is still unclear, although several factors, including a dysbalance of cytokines, are associated with loss of bone mass. Alterations in the serum levels of cytokines have been observed in patients with MDD, AN, and other psychiatric disorders. Therefore, we examined serum levels of cytokines, markers of bone turnover, and BMD in 13 patients with MDD and a lifetime history of AN. Bone turnover markers (osteocalcin and C-terminal degradation products of type I collagen) and tumor necrosis factor alpha (TNF-alpha) in patients were significantly increased compared with those of the control group. Osteoprotegerin (OPG) in patients was significantly decreased. Eight of 13 patients (62%) displayed osteopenia at the lumbar spine. TNF-alpha correlated significantly with C-terminal degradation products of type I collagen, an osteoclastic marker, but significantly negatively with OPG. Our data suggest that TNF-alpha and OPG may play a role in the pathogenetic process underlying osteopenia in these patients. |
| doi_str_mv | 10.1007/s00198-004-1711-5 |
| format | Article |
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The pathogenetic process underlying osteopenia in MDD and AN is still unclear, although several factors, including a dysbalance of cytokines, are associated with loss of bone mass. Alterations in the serum levels of cytokines have been observed in patients with MDD, AN, and other psychiatric disorders. Therefore, we examined serum levels of cytokines, markers of bone turnover, and BMD in 13 patients with MDD and a lifetime history of AN. Bone turnover markers (osteocalcin and C-terminal degradation products of type I collagen) and tumor necrosis factor alpha (TNF-alpha) in patients were significantly increased compared with those of the control group. Osteoprotegerin (OPG) in patients was significantly decreased. Eight of 13 patients (62%) displayed osteopenia at the lumbar spine. TNF-alpha correlated significantly with C-terminal degradation products of type I collagen, an osteoclastic marker, but significantly negatively with OPG. Our data suggest that TNF-alpha and OPG may play a role in the pathogenetic process underlying osteopenia in these patients.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-004-1711-5</identifier><identifier>PMID: 15300363</identifier><language>eng</language><publisher>London: Springer</publisher><subject>Adolescent ; Adult ; Anorexia Nervosa - blood ; Anorexia Nervosa - complications ; Anorexia Nervosa - physiopathology ; Biological and medical sciences ; Bone Density ; Bone Diseases, Metabolic - blood ; Bone Diseases, Metabolic - etiology ; Bone Diseases, Metabolic - physiopathology ; Cytokines - blood ; Depressive Disorder, Major - blood ; Depressive Disorder, Major - complications ; Depressive Disorder, Major - physiopathology ; Diseases of the osteoarticular system ; Female ; Glycoproteins - blood ; Hormones - blood ; Humans ; Lumbar Vertebrae - physiopathology ; Medical sciences ; Osteoporosis. 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Paget disease ; Osteoprotegerin ; Receptors, Cytoplasmic and Nuclear - blood ; Receptors, Tumor Necrosis Factor - blood ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>Osteoporosis international, 2005-04, Vol.16 (4), p.424-429</ispartof><rights>2005 INIST-CNRS</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ff0270271df0551511729133f838f7bfd8a2a2a0314f60b2a91f897f4e18bbc83</citedby><cites>FETCH-LOGICAL-c356t-ff0270271df0551511729133f838f7bfd8a2a2a0314f60b2a91f897f4e18bbc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16632919$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15300363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAHL, Kai G</creatorcontrib><creatorcontrib>RUDOLF, Sebastian</creatorcontrib><creatorcontrib>DIBBELT, Leif</creatorcontrib><creatorcontrib>STOECKELHUBER, Beate M</creatorcontrib><creatorcontrib>GEHL, Hans-Björn</creatorcontrib><creatorcontrib>HOHAGEN, Fritz</creatorcontrib><creatorcontrib>SCHWEIGER, Ulrich</creatorcontrib><title>Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><description>Low bone mineral density (BMD) is a frequent, often persistent complication in patients with major depressive disorder (MDD) and anorexia nervosa (AN) that increases the risk of pathologic fractures. The pathogenetic process underlying osteopenia in MDD and AN is still unclear, although several factors, including a dysbalance of cytokines, are associated with loss of bone mass. Alterations in the serum levels of cytokines have been observed in patients with MDD, AN, and other psychiatric disorders. Therefore, we examined serum levels of cytokines, markers of bone turnover, and BMD in 13 patients with MDD and a lifetime history of AN. Bone turnover markers (osteocalcin and C-terminal degradation products of type I collagen) and tumor necrosis factor alpha (TNF-alpha) in patients were significantly increased compared with those of the control group. Osteoprotegerin (OPG) in patients was significantly decreased. Eight of 13 patients (62%) displayed osteopenia at the lumbar spine. TNF-alpha correlated significantly with C-terminal degradation products of type I collagen, an osteoclastic marker, but significantly negatively with OPG. Our data suggest that TNF-alpha and OPG may play a role in the pathogenetic process underlying osteopenia in these patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anorexia Nervosa - blood</subject><subject>Anorexia Nervosa - complications</subject><subject>Anorexia Nervosa - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bone Density</subject><subject>Bone Diseases, Metabolic - blood</subject><subject>Bone Diseases, Metabolic - etiology</subject><subject>Bone Diseases, Metabolic - physiopathology</subject><subject>Cytokines - blood</subject><subject>Depressive Disorder, Major - blood</subject><subject>Depressive Disorder, Major - complications</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Glycoproteins - blood</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Medical sciences</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Osteoprotegerin</subject><subject>Receptors, Cytoplasmic and Nuclear - blood</subject><subject>Receptors, Tumor Necrosis Factor - blood</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkd-K1DAUxoMo7jj6AN5IEPSumtM0bXMp619Y8EbBu5C2J7sZ2mTMSUfnTXxcM8zIgiQQyPl938nJx9hzEG9AiO4tCQG6r4RoKugAKvWAbaCRsqp1qx6yjdCyq3QDP67YE6KdKBqtu8fsCpQUQrZyw_68xzGhJZx4pIxxn2LGW0w-cBsm7sO_6hAD8rymEA-Yyj0_xjXccoeLnZHvbfYYMvFfPt_xxe5i4hPuExL5A_LJU0xT0Z08LZ-9w-wX5HeeckxHHl2pxIS_veUB0yGSfcoeOTsTPrucW_b944dv15-rm6-fvly_u6lGqdpcOSfqrmyYnFAKFEBXa5DS9bJ33eCm3tZlCQmNa8VQWw2u151rEPphGHu5Za_PvmXynytSNounEefZBowrmbZTtW6UKuDL_8BdLN9R3mZq6HvZNKXvlsEZGlMkSujMPvnFpqMBYU6ZmXNmpmRmTpmZk_GLi_E6LDjdKy4hFeDVBbA02tklG0ZP91zbyjKzln8BTBShqg</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>KAHL, Kai G</creator><creator>RUDOLF, Sebastian</creator><creator>DIBBELT, Leif</creator><creator>STOECKELHUBER, Beate M</creator><creator>GEHL, Hans-Björn</creator><creator>HOHAGEN, Fritz</creator><creator>SCHWEIGER, Ulrich</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa</title><author>KAHL, Kai G ; RUDOLF, Sebastian ; DIBBELT, Leif ; STOECKELHUBER, Beate M ; GEHL, Hans-Björn ; HOHAGEN, Fritz ; SCHWEIGER, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ff0270271df0551511729133f838f7bfd8a2a2a0314f60b2a91f897f4e18bbc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anorexia Nervosa - blood</topic><topic>Anorexia Nervosa - complications</topic><topic>Anorexia Nervosa - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bone Density</topic><topic>Bone Diseases, Metabolic - blood</topic><topic>Bone Diseases, Metabolic - etiology</topic><topic>Bone Diseases, Metabolic - physiopathology</topic><topic>Cytokines - blood</topic><topic>Depressive Disorder, Major - blood</topic><topic>Depressive Disorder, Major - complications</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Glycoproteins - blood</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Medical sciences</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Osteoprotegerin</topic><topic>Receptors, Cytoplasmic and Nuclear - blood</topic><topic>Receptors, Tumor Necrosis Factor - blood</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAHL, Kai G</creatorcontrib><creatorcontrib>RUDOLF, Sebastian</creatorcontrib><creatorcontrib>DIBBELT, Leif</creatorcontrib><creatorcontrib>STOECKELHUBER, Beate M</creatorcontrib><creatorcontrib>GEHL, Hans-Björn</creatorcontrib><creatorcontrib>HOHAGEN, Fritz</creatorcontrib><creatorcontrib>SCHWEIGER, Ulrich</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAHL, Kai G</au><au>RUDOLF, Sebastian</au><au>DIBBELT, Leif</au><au>STOECKELHUBER, Beate M</au><au>GEHL, Hans-Björn</au><au>HOHAGEN, Fritz</au><au>SCHWEIGER, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa</atitle><jtitle>Osteoporosis international</jtitle><addtitle>Osteoporos Int</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>16</volume><issue>4</issue><spage>424</spage><epage>429</epage><pages>424-429</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Low bone mineral density (BMD) is a frequent, often persistent complication in patients with major depressive disorder (MDD) and anorexia nervosa (AN) that increases the risk of pathologic fractures. The pathogenetic process underlying osteopenia in MDD and AN is still unclear, although several factors, including a dysbalance of cytokines, are associated with loss of bone mass. Alterations in the serum levels of cytokines have been observed in patients with MDD, AN, and other psychiatric disorders. Therefore, we examined serum levels of cytokines, markers of bone turnover, and BMD in 13 patients with MDD and a lifetime history of AN. Bone turnover markers (osteocalcin and C-terminal degradation products of type I collagen) and tumor necrosis factor alpha (TNF-alpha) in patients were significantly increased compared with those of the control group. Osteoprotegerin (OPG) in patients was significantly decreased. Eight of 13 patients (62%) displayed osteopenia at the lumbar spine. TNF-alpha correlated significantly with C-terminal degradation products of type I collagen, an osteoclastic marker, but significantly negatively with OPG. Our data suggest that TNF-alpha and OPG may play a role in the pathogenetic process underlying osteopenia in these patients.</abstract><cop>London</cop><pub>Springer</pub><pmid>15300363</pmid><doi>10.1007/s00198-004-1711-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Anorexia Nervosa - blood Anorexia Nervosa - complications Anorexia Nervosa - physiopathology Biological and medical sciences Bone Density Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - etiology Bone Diseases, Metabolic - physiopathology Cytokines - blood Depressive Disorder, Major - blood Depressive Disorder, Major - complications Depressive Disorder, Major - physiopathology Diseases of the osteoarticular system Female Glycoproteins - blood Hormones - blood Humans Lumbar Vertebrae - physiopathology Medical sciences Osteoporosis. Osteomalacia. Paget disease Osteoprotegerin Receptors, Cytoplasmic and Nuclear - blood Receptors, Tumor Necrosis Factor - blood Tumor Necrosis Factor-alpha - analysis |
| title | Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa |
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