Mycobacterium tuberculosis secreted antigen (MTSA-10) inhibits macrophage response to lipopolysaccharide by redox regulation of phosphatases
The present study was undertaken to investigate the possible role of a 10-kDa, secretory antigenic protein of Mtb (MTSA-10) in regulating macrophase response to lipopolysacchride (LPS). MTSA-10 inhibited the lipopolysaccharide (LPS)-induced oxidant species generation in the macrophage. Treatment of...
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| Veröffentlicht in: | Indian journal of experimental biology 2009-06, Vol.47 (6), p.505-519 |
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| container_title | Indian journal of experimental biology |
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| creator | Basu, Sandip Kumar Kumar, Dhiraj Ganguly, Niladri Rao, Kanury Venkata Subba Sharma, Pawan |
| description | The present study was undertaken to investigate the possible role of a 10-kDa, secretory antigenic protein of Mtb (MTSA-10) in regulating macrophase response to lipopolysacchride (LPS). MTSA-10 inhibited the lipopolysaccharide (LPS)-induced oxidant species generation in the macrophage. Treatment of macrophages with MTSA-10 activated their protein tyrosine phosphatases (PTPs) in a redox-regulated fashion. These activated phosphatases then interfered with the early events of LPS signaling and lower the strength and magnitude of the signal generated, thereby preventing macrophages from making an effective immune response. Mycobacterium tuberculosis Region of Deletion-1 (RD-1)-specific secretory antigen MTSA-10 (encoded by ORF Rv3874 of Mtb genome) modulated the macrophage signaling machinery and prevented it from responding to further activation by LPS. |
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MTSA-10 inhibited the lipopolysaccharide (LPS)-induced oxidant species generation in the macrophage. Treatment of macrophages with MTSA-10 activated their protein tyrosine phosphatases (PTPs) in a redox-regulated fashion. These activated phosphatases then interfered with the early events of LPS signaling and lower the strength and magnitude of the signal generated, thereby preventing macrophages from making an effective immune response. 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| ispartof | Indian journal of experimental biology, 2009-06, Vol.47 (6), p.505-519 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Bacterial Proteins - immunology Bacterial Proteins - pharmacology Cell Line Humans Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Mice Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - immunology Oxidation-Reduction Phosphoric Monoester Hydrolases - metabolism Reactive Oxygen Species - metabolism Signal Transduction - physiology |
| title | Mycobacterium tuberculosis secreted antigen (MTSA-10) inhibits macrophage response to lipopolysaccharide by redox regulation of phosphatases |
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